TY - JOUR T1 - Comparative performance of the ParaSight F test for detection of Plasmodium falciparum in malaria-immune and nonimmune populations in Irian Jaya, Indonesia. AU - Fryauff,D J, AU - Gomez-Saladin,E, AU - Purnomo,, AU - Sumawinata,I, AU - Sutamihardja,M A, AU - Tuti,S, AU - Subianto,B, AU - Richie,T L, PY - 1997/1/1/pubmed PY - 1998/3/24/medline PY - 1997/1/1/entrez KW - Adult KW - Age Factors KW - Asia KW - Biology KW - Child KW - Clinical Research KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Examinations And Diagnoses KW - Immunity KW - Indonesia KW - Laboratory Examinations And Diagnoses KW - Malaria--prevention and control KW - Parasitic Diseases KW - Physiology KW - Population KW - Population Characteristics KW - Research Methodology KW - Research Report KW - Southeastern Asia KW - Youth SP - 547 EP - 52 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 75 IS - 6 N2 - A comparison was made of the performance of the ParaSight F test (F test) for detection of Plasmodium falciparum in blood from malaria-immune (410 native Irianese) and nonimmune (369 new transmigrants) populations in Irian Jaya, Indonesia, where malaria is hyperendemic and all four species of human malaria occur. There were highly significant differences between populations in the sensitivity (Irianese, 60% versus transmigrants, 84%; P < 0.001) and specificity (Irianese, 97% versus transmigrants, 84%; P < 0.001) of the F test. The test had comparably high levels of sensitivity for Irianese children aged < or = 10 years, both age groups of transmigrants (76-85%), but low sensitivity for Irianese aged > 10 years (40%), among whom only 7% of parasitaemias < 120 per microliter and 69% of those > 120 per microliter were detected. Specificity was comparably high for transmigrant children aged < or = 10 years and both age groups of Irianese (93-98%). The low specificity for transmigrants aged > 10 years (79%) was due to a preponderance of false positives, frequently identified by microscopy as P. vivax. The results suggest that comparison based on microscopy underestimated the performance of the ParaSight F test and that malaria immune status, irrespective of P. falciparum density, may influence the test's sensitivity. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/9509627/Comparative_performance_of_the_ParaSight_F_test_for_detection_of_Plasmodium_falciparum_in_malaria_immune_and_nonimmune_populations_in_Irian_Jaya_Indonesia_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9509627/ DB - PRIME DP - Unbound Medicine ER -