Abstract
OBJECTIVE
To determine measles vaccine efficacy.
DESIGN
Between October and November 1996, during a measles outbreak in Mbare, a retrospective study through interviews with care givers was performed. Thirty clusters were randomly selected and seven or more, nine to 35 months old children in each cluster were selected.
SETTING
Mbare suburb, City of Harare
SUBJECTS
294 children aged nine to 35 months.
MAIN OUTCOME MEASURES
Cases were classified in a two by two contingency table based on their vaccination status and measles status during the outbreak. Vaccine coverage, attack rates and vaccine efficacy were then calculated.
RESULTS
Of the 294 children selected, 83% (95% CI 78.7, 87.3) were vaccinated and 9.5% had measles. The attack rate for the vaccinated was 6.9% while that for the unvaccinated was 22%. Vaccine efficacy was 68%.
CONCLUSION
Vaccine efficacy was found to be low. There is need for serological confirmation of measles cases during outbreaks; for a comprehensive evaluation of the measles vaccination programme in Mbare and for maintenance of high measles vaccine coverage rates to reduce morbidity.
TY - JOUR
T1 - Evaluation of a measles vaccine efficacy during a measles outbreak in Mbare, City of Harare Zimbabwe.
AU - Mahomva,A I,
AU - Moyo,I M,
AU - Mbengeranwa,L O,
PY - 1998/3/24/pubmed
PY - 1998/3/24/medline
PY - 1998/3/24/entrez
KW - Africa
KW - Africa South Of The Sahara
KW - Age Factors
KW - Child
KW - Delivery Of Health Care
KW - Demographic Factors
KW - Developing Countries
KW - Diseases
KW - Eastern Africa
KW - English Speaking Africa
KW - Health
KW - Health Services
KW - Immunization
KW - Measles
KW - Measurement
KW - Population
KW - Population Characteristics
KW - Prevalence
KW - Primary Health Care
KW - Research Methodology
KW - Research Report
KW - Urban Population
KW - Vaccination
KW - Vaccines
KW - Viral Diseases
KW - Youth
KW - Zimbabwe
SP - 254
EP - 6
JF - The Central African journal of medicine
JO - Cent Afr J Med
VL - 43
IS - 9
N2 - OBJECTIVE: To determine measles vaccine efficacy. DESIGN: Between October and November 1996, during a measles outbreak in Mbare, a retrospective study through interviews with care givers was performed. Thirty clusters were randomly selected and seven or more, nine to 35 months old children in each cluster were selected. SETTING: Mbare suburb, City of Harare SUBJECTS: 294 children aged nine to 35 months. MAIN OUTCOME MEASURES: Cases were classified in a two by two contingency table based on their vaccination status and measles status during the outbreak. Vaccine coverage, attack rates and vaccine efficacy were then calculated. RESULTS: Of the 294 children selected, 83% (95% CI 78.7, 87.3) were vaccinated and 9.5% had measles. The attack rate for the vaccinated was 6.9% while that for the unvaccinated was 22%. Vaccine efficacy was 68%. CONCLUSION: Vaccine efficacy was found to be low. There is need for serological confirmation of measles cases during outbreaks; for a comprehensive evaluation of the measles vaccination programme in Mbare and for maintenance of high measles vaccine coverage rates to reduce morbidity.
SN - 0008-9176
UR - https://www.unboundmedicine.com/medline/citation/9509644/Evaluation_of_a_measles_vaccine_efficacy_during_a_measles_outbreak_in_Mbare_City_of_Harare_Zimbabwe_
L2 - http://www.diseaseinfosearch.org/result/4535
DB - PRIME
DP - Unbound Medicine
ER -
