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RETRACTED ARTICLE

Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis.
Can J Anaesth. 1998 Feb; 45(2):153-6.CJ

Abstract

PURPOSE

A high incidence of postoperative nausea and vomiting (PONV) has been noted in patients with a history of postoperative emesis. This study was undertaken to compare the efficacy of granisetron, droperidol and metoclopramide, in the prevention of PONV in such patients undergoing general anaesthesia for major gynaecological surgery.

METHODS

In a randomised, double-blind study, 90 female patients received 2.5 mg granisetron, 1.25 mg droperidol or 10 mg metoclopramide (n = 30 of each) i.v. immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia.

RESULTS

The incidence of PONV was 20% with granisetron, 57% with droperidol and 60% with metoclopramide (P < 0.05; overall Fisher's exact probability test). No clinically adverse events were observed in any group.

CONCLUSION

Granisetron is more effective than droperidol or metoclopramide in preventing PONV in female patients with a history of postoperative emesis.

Authors+Show Affiliations

Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9512851

Citation

Fujii, Y, et al. "Prevention of PONV With Granisetron, Droperidol or Metoclopramide in Patients With Postoperative Emesis." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 45, no. 2, 1998, pp. 153-6.
Fujii Y, Saitoh Y, Tanaka H, et al. Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis. Can J Anaesth. 1998;45(2):153-6.
Fujii, Y., Saitoh, Y., Tanaka, H., & Toyooka, H. (1998). Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 45(2), 153-6.
Fujii Y, et al. Prevention of PONV With Granisetron, Droperidol or Metoclopramide in Patients With Postoperative Emesis. Can J Anaesth. 1998;45(2):153-6. PubMed PMID: 9512851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis. AU - Fujii,Y, AU - Saitoh,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/3/26/pubmed PY - 1998/3/26/medline PY - 1998/3/26/entrez SP - 153 EP - 6 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 45 IS - 2 N2 - PURPOSE: A high incidence of postoperative nausea and vomiting (PONV) has been noted in patients with a history of postoperative emesis. This study was undertaken to compare the efficacy of granisetron, droperidol and metoclopramide, in the prevention of PONV in such patients undergoing general anaesthesia for major gynaecological surgery. METHODS: In a randomised, double-blind study, 90 female patients received 2.5 mg granisetron, 1.25 mg droperidol or 10 mg metoclopramide (n = 30 of each) i.v. immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia. RESULTS: The incidence of PONV was 20% with granisetron, 57% with droperidol and 60% with metoclopramide (P < 0.05; overall Fisher's exact probability test). No clinically adverse events were observed in any group. CONCLUSION: Granisetron is more effective than droperidol or metoclopramide in preventing PONV in female patients with a history of postoperative emesis. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/9512851/Prevention_of_PONV_with_granisetron_droperidol_or_metoclopramide_in_patients_with_postoperative_emesis_ L2 - https://dx.doi.org/10.1007/BF03013255 DB - PRIME DP - Unbound Medicine ER -