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High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda.
Ital J Gastroenterol Hepatol 1997; 29(6):543-7IJ

Abstract

BACKGROUND

A strong association between sporadic porphyria cutanea tarda and chronic hepatitis C virus infection was recently described in Italy, France and Spain.

AIMS

To explore whether hepatitis C virus genotype plays a role in porphyria cutanea tarda complicating chronic hepatitis C.

PATIENTS

Forty-seven hepatitis C virus-positive porphyria cutanea tarda patients and a control group of 45 patients of similar age with hepatitis C virus-associated chronic liver disease.

METHODS

Comparison of frequency of hepatitis C virus genotypes in the two groups and in relation to the age of patients, hepatic histopathology and with the presence of other factors potentially able to trigger porphyria cutanea tarda.

RESULTS

A single genotype, hepatitis C virus 1b, was found to be present in nearly 90% of porphyria cutanea tarda-associated chronic liver disease, significantly exceeding the frequency of the same genotype in the control group (p = 0.0001). The presence of hepatitis C virus 1b was not related to the age of patients or disease severity as evaluated by hepatic histopathology.

CONCLUSIONS

Hepatitis C virus-associated chronic hepatitis found in the majority of Italian patients with porphyria cutanea tarda is usually sustained by hepatitis C virus genotype 1b. This viral strain might have a direct pathogenic role in inducing porphyria cutanea tarda or could increase the susceptibility of patients of other triggering factors such as iron overload or alcohol abuse.

Authors+Show Affiliations

Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9513830

Citation

Sampietro, M, et al. "High Prevalence of Hepatitis C Virus Type 1b in Italian Patients With Porphyria Cutanea Tarda." Italian Journal of Gastroenterology and Hepatology, vol. 29, no. 6, 1997, pp. 543-7.
Sampietro M, Fracanzani AL, Corbetta N, et al. High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda. Ital J Gastroenterol Hepatol. 1997;29(6):543-7.
Sampietro, M., Fracanzani, A. L., Corbetta, N., Amato, M., Mattioli, M., Molteni, V., ... Fargion, S. (1997). High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda. Italian Journal of Gastroenterology and Hepatology, 29(6), pp. 543-7.
Sampietro M, et al. High Prevalence of Hepatitis C Virus Type 1b in Italian Patients With Porphyria Cutanea Tarda. Ital J Gastroenterol Hepatol. 1997;29(6):543-7. PubMed PMID: 9513830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of hepatitis C virus type 1b in Italian patients with Porphyria cutanea tarda. AU - Sampietro,M, AU - Fracanzani,A L, AU - Corbetta,N, AU - Amato,M, AU - Mattioli,M, AU - Molteni,V, AU - Fiorelli,G, AU - Fargion,S, PY - 1998/3/26/pubmed PY - 1998/3/26/medline PY - 1998/3/26/entrez SP - 543 EP - 7 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 29 IS - 6 N2 - BACKGROUND: A strong association between sporadic porphyria cutanea tarda and chronic hepatitis C virus infection was recently described in Italy, France and Spain. AIMS: To explore whether hepatitis C virus genotype plays a role in porphyria cutanea tarda complicating chronic hepatitis C. PATIENTS: Forty-seven hepatitis C virus-positive porphyria cutanea tarda patients and a control group of 45 patients of similar age with hepatitis C virus-associated chronic liver disease. METHODS: Comparison of frequency of hepatitis C virus genotypes in the two groups and in relation to the age of patients, hepatic histopathology and with the presence of other factors potentially able to trigger porphyria cutanea tarda. RESULTS: A single genotype, hepatitis C virus 1b, was found to be present in nearly 90% of porphyria cutanea tarda-associated chronic liver disease, significantly exceeding the frequency of the same genotype in the control group (p = 0.0001). The presence of hepatitis C virus 1b was not related to the age of patients or disease severity as evaluated by hepatic histopathology. CONCLUSIONS: Hepatitis C virus-associated chronic hepatitis found in the majority of Italian patients with porphyria cutanea tarda is usually sustained by hepatitis C virus genotype 1b. This viral strain might have a direct pathogenic role in inducing porphyria cutanea tarda or could increase the susceptibility of patients of other triggering factors such as iron overload or alcohol abuse. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/9513830/High_prevalence_of_hepatitis_C_virus_type_1b_in_Italian_patients_with_Porphyria_cutanea_tarda_ L2 - http://www.diseaseinfosearch.org/result/5879 DB - PRIME DP - Unbound Medicine ER -