Tags

Type your tag names separated by a space and hit enter

United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors.

Abstract

OBJECTIVES

To report on the prevalence of retinopathy in patients with newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) and to evaluate the relationship of retinopathy to clinical and biochemical variables.

DESIGN

A multicenter, randomized, controlled clinical study of therapy in patients with NIDDM.

SETTING AND PATIENTS

Patients were part of the United Kingdom Prospective Diabetes Study, a 23-center study of 2964 white patients who had both eyes photographed and assessed.

OUTCOME MEASURES

The presence and severity of diabetic retinopathy were evaluated by sex, and the relationship of retinopathy to medical and biochemical parameters was assessed.

RESULTS

Retinopathy, defined as microaneurysms or worse lesions in at least 1 eye, was present in 39% of men and 35% of women. Marked retinopathy with cotton wool spots or intraretinal microvascular abnormalities was present in 8% of men and 4% of women. The severity of retinopathy was related in both sexes to higher fasting plasma glucose levels, higher systolic and diastolic blood pressure, lower serum insulin levels, and reduced beta-cell function. In addition, in men, increased alcohol consumption was related to increased severity of retinopathy, while leaner women had more severe eye lesions. Visual acuity was normal in most patients, but in men there was a trend for those with more severe retinal lesions to have worse visual acuity.

CONCLUSIONS

Diabetic retinopathy is common in patients with newly diagnosed NIDDM. Careful ophthalmic assessment at diagnosis is important.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Endocrinology, Diabetes & Metabolic Medicine, St Thomas' Hospital, London, England.

    , , , , ,

    Source

    MeSH

    Alcohol Drinking
    Blood Glucose
    Blood Pressure
    Diabetes Mellitus, Type 2
    Diabetic Retinopathy
    Female
    Humans
    Insulin
    Male
    Middle Aged
    Prevalence
    Prospective Studies
    Risk Factors
    United Kingdom
    Visual Acuity

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9514482

    Citation

    Kohner, E M., et al. "United Kingdom Prospective Diabetes Study, 30: Diabetic Retinopathy at Diagnosis of Non-insulin-dependent Diabetes Mellitus and Associated Risk Factors." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 116, no. 3, 1998, pp. 297-303.
    Kohner EM, Aldington SJ, Stratton IM, et al. United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. Arch Ophthalmol. 1998;116(3):297-303.
    Kohner, E. M., Aldington, S. J., Stratton, I. M., Manley, S. E., Holman, R. R., Matthews, D. R., & Turner, R. C. (1998). United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. Archives of Ophthalmology (Chicago, Ill. : 1960), 116(3), pp. 297-303.
    Kohner EM, et al. United Kingdom Prospective Diabetes Study, 30: Diabetic Retinopathy at Diagnosis of Non-insulin-dependent Diabetes Mellitus and Associated Risk Factors. Arch Ophthalmol. 1998;116(3):297-303. PubMed PMID: 9514482.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. AU - Kohner,E M, AU - Aldington,S J, AU - Stratton,I M, AU - Manley,S E, AU - Holman,R R, AU - Matthews,D R, AU - Turner,R C, PY - 1998/3/26/pubmed PY - 1998/3/26/medline PY - 1998/3/26/entrez SP - 297 EP - 303 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 116 IS - 3 N2 - OBJECTIVES: To report on the prevalence of retinopathy in patients with newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) and to evaluate the relationship of retinopathy to clinical and biochemical variables. DESIGN: A multicenter, randomized, controlled clinical study of therapy in patients with NIDDM. SETTING AND PATIENTS: Patients were part of the United Kingdom Prospective Diabetes Study, a 23-center study of 2964 white patients who had both eyes photographed and assessed. OUTCOME MEASURES: The presence and severity of diabetic retinopathy were evaluated by sex, and the relationship of retinopathy to medical and biochemical parameters was assessed. RESULTS: Retinopathy, defined as microaneurysms or worse lesions in at least 1 eye, was present in 39% of men and 35% of women. Marked retinopathy with cotton wool spots or intraretinal microvascular abnormalities was present in 8% of men and 4% of women. The severity of retinopathy was related in both sexes to higher fasting plasma glucose levels, higher systolic and diastolic blood pressure, lower serum insulin levels, and reduced beta-cell function. In addition, in men, increased alcohol consumption was related to increased severity of retinopathy, while leaner women had more severe eye lesions. Visual acuity was normal in most patients, but in men there was a trend for those with more severe retinal lesions to have worse visual acuity. CONCLUSIONS: Diabetic retinopathy is common in patients with newly diagnosed NIDDM. Careful ophthalmic assessment at diagnosis is important. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/9514482/full_citation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/116/pg/297 DB - PRIME DP - Unbound Medicine ER -