Tags

Type your tag names separated by a space and hit enter

Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO.
Virology. 1998 Mar 15; 242(2):425-34.V

Abstract

Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States. Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was performed on HTLV-II seropositive subjects including 97 U.S. blood donors without major risk factors for HTLV-II infection, 53 injection drug users (IDU), and 10 American Indian blood donors. Three new HTLV-II RFLP types were confirmed with DNA sequencing and phylogenetic analysis. HTLV-II RFLP type aO (Switzer classification) was associated with older age [adjusted odds ratio (OR) 1.06 per year of age, 95% confidence interval (CI) 1.02-1.09] and with Black (OR 5.24, 95% CI 1.90-14.47) and White (OR 4.43, 95% CI 1.67-11.75) race/ethnicity. These data are consistent with an age-cohort effect for HTLV-II RFLP type aO among older White and Black IDU and blood donors. This finding could be explained by an epidemic of non-aO HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type aO among older Black and White persons.

Authors+Show Affiliations

Department of Laboratory Medicine, University of California San Francisco 94143, USA. murphy@labmed.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9514966

Citation

Murphy, E L., et al. "Molecular Epidemiology of HTLV-II Among United States Blood Donors and Intravenous Drug Users: an Age-cohort Effect for HTLV-II RFLP Type AO." Virology, vol. 242, no. 2, 1998, pp. 425-34.
Murphy EL, Mahieux R, de Thé G, et al. Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO. Virology. 1998;242(2):425-34.
Murphy, E. L., Mahieux, R., de Thé, G., Tekaia, F., Ameti, D., Horton, J., & Gessain, A. (1998). Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO. Virology, 242(2), 425-34.
Murphy EL, et al. Molecular Epidemiology of HTLV-II Among United States Blood Donors and Intravenous Drug Users: an Age-cohort Effect for HTLV-II RFLP Type AO. Virology. 1998 Mar 15;242(2):425-34. PubMed PMID: 9514966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology of HTLV-II among United States blood donors and intravenous drug users: an age-cohort effect for HTLV-II RFLP type aO. AU - Murphy,E L, AU - Mahieux,R, AU - de Thé,G, AU - Tekaia,F, AU - Ameti,D, AU - Horton,J, AU - Gessain,A, PY - 1998/3/26/pubmed PY - 1998/3/26/medline PY - 1998/3/26/entrez SP - 425 EP - 34 JF - Virology JO - Virology VL - 242 IS - 2 N2 - Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States. Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was performed on HTLV-II seropositive subjects including 97 U.S. blood donors without major risk factors for HTLV-II infection, 53 injection drug users (IDU), and 10 American Indian blood donors. Three new HTLV-II RFLP types were confirmed with DNA sequencing and phylogenetic analysis. HTLV-II RFLP type aO (Switzer classification) was associated with older age [adjusted odds ratio (OR) 1.06 per year of age, 95% confidence interval (CI) 1.02-1.09] and with Black (OR 5.24, 95% CI 1.90-14.47) and White (OR 4.43, 95% CI 1.67-11.75) race/ethnicity. These data are consistent with an age-cohort effect for HTLV-II RFLP type aO among older White and Black IDU and blood donors. This finding could be explained by an epidemic of non-aO HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type aO among older Black and White persons. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/9514966/Molecular_epidemiology_of_HTLV_II_among_United_States_blood_donors_and_intravenous_drug_users:_an_age_cohort_effect_for_HTLV_II_RFLP_type_aO_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042682297990097 DB - PRIME DP - Unbound Medicine ER -