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Pregnancy and liver disease.
Forum (Genova). 1998 Jan-Mar; 8(1):42-58.F

Abstract

Liver disease in pregnancy should be considered in 3 categories: pre-existing disease, disease peculiar to pregnancy and coincident acute liver or gall-stone disease. In addition the time of onset of diagnosis in terms of the trimester of gestation must be verified, as the diseases peculiar to pregancy have a characteristic time of onset. In the last trimester closes obstetric management is required for the constellation of abnormal liver function tests, nausea and/or vomiting and abdominal pain. This may be due to severe pre-eclampsia, HELLP (haemolysis, elevated liver enzymes and low platelets) syndrome or acute fatty liver of pregnancy with or without sub-capsular hepatic haematomas, amongst which there is an overlap. Early delivery is curative. A molecular basis consisting of long chain 3-hydroxyl CoA dehydroxegenase deficiency in heterozygote mothers underlies this clinical syndrome. Ursodeoxycholic acid is now established treatment for intra-hepatic cholestasis of pregnancy and appears to improve foetal outcome. Hepatitis B vaccination and immunoglobulin at birth prevents chronic hepatitis B in children of HBsAg (hepatitis B surface antigen) positive carrier mothers.

Authors+Show Affiliations

Hepato-biliary and Liver Transplantation Unit, The Royal Free Hospital, London, England, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9514993

Citation

Burroughs, A K.. "Pregnancy and Liver Disease." Forum (Genoa, Italy), vol. 8, no. 1, 1998, pp. 42-58.
Burroughs AK. Pregnancy and liver disease. Forum (Genova). 1998;8(1):42-58.
Burroughs, A. K. (1998). Pregnancy and liver disease. Forum (Genoa, Italy), 8(1), 42-58.
Burroughs AK. Pregnancy and Liver Disease. Forum (Genova). 1998 Jan-Mar;8(1):42-58. PubMed PMID: 9514993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy and liver disease. A1 - Burroughs,A K, PY - 1998/6/17/pubmed PY - 1998/6/17/medline PY - 1998/6/17/entrez SP - 42 EP - 58 JF - Forum (Genoa, Italy) JO - Forum (Genova) VL - 8 IS - 1 N2 - Liver disease in pregnancy should be considered in 3 categories: pre-existing disease, disease peculiar to pregnancy and coincident acute liver or gall-stone disease. In addition the time of onset of diagnosis in terms of the trimester of gestation must be verified, as the diseases peculiar to pregancy have a characteristic time of onset. In the last trimester closes obstetric management is required for the constellation of abnormal liver function tests, nausea and/or vomiting and abdominal pain. This may be due to severe pre-eclampsia, HELLP (haemolysis, elevated liver enzymes and low platelets) syndrome or acute fatty liver of pregnancy with or without sub-capsular hepatic haematomas, amongst which there is an overlap. Early delivery is curative. A molecular basis consisting of long chain 3-hydroxyl CoA dehydroxegenase deficiency in heterozygote mothers underlies this clinical syndrome. Ursodeoxycholic acid is now established treatment for intra-hepatic cholestasis of pregnancy and appears to improve foetal outcome. Hepatitis B vaccination and immunoglobulin at birth prevents chronic hepatitis B in children of HBsAg (hepatitis B surface antigen) positive carrier mothers. SN - 1121-8142 UR - https://www.unboundmedicine.com/medline/citation/9514993/Pregnancy_and_liver_disease_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -