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Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects.
Urol Int 1998; 60(1):41-6UI

Abstract

OBJECTIVE

The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine.

MATERIAL AND METHODS

Urine specimens were directly collected from the bladder and the kidney, of 11 stone formers and 11 control subjects under general anesthesia. The type of crystals present in urine as well as their size, number by cubic millimeter and state of aggregation were determined. In addition, calcium, magnesium, sodium, chloride, phosphate, citrate, oxalate, pyrophosphate and uric acid were measured in order to evaluate the calcium saturation status (EQUIL V program).

RESULTS

Calcium oxalate crystals were detected in 3 stone formers (27%) and 2 control subjects (18%) in vesical urine and in 4 stone formers (36%) and 3 control subjects (27%) in renal urine. Only 2 stone formers presented with simultaneous renal and vesical crystalluria. Subjects of the two groups with and without renal crystalluria were compared in terms of chemical composition and calcium oxalate saturation of renal urine. Crystalluric subjects (n = 7) had significantly higher uricosuria (p = 0.02), calciuria (p = 0.04), magnesiuria (p = 0.04) and calcium oxalate molar product (p = 0.05) than noncrystalluric (n = 15); calcium oxalate saturation was similar (p = 0.5).

CONCLUSIONS

Beyond theorical considerations on lithogenesis, our observations and in particular the apparent discrepancy between renal and vesical crystalluria pose the problem of the clinical interest of the evaluation of calcium oxalate crystalluria based on freshly voided urine in the assessing the lithogenic risk or in the follow-up of patients who are particularly prone to stone recurrence.

Authors+Show Affiliations

Department of Urology, Lapeyronie University Hospital, Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9519420

Citation

Robert, M, et al. "Study of Calcium Oxalate Crystalluria On Renal and Vesical Urines in Stone Formers and Normal Subjects." Urologia Internationalis, vol. 60, no. 1, 1998, pp. 41-6.
Robert M, Boularan AM, Delbos O, et al. Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. Urol Int. 1998;60(1):41-6.
Robert, M., Boularan, A. M., Delbos, O., Guiter, J., & Descomps, B. (1998). Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. Urologia Internationalis, 60(1), pp. 41-6.
Robert M, et al. Study of Calcium Oxalate Crystalluria On Renal and Vesical Urines in Stone Formers and Normal Subjects. Urol Int. 1998;60(1):41-6. PubMed PMID: 9519420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. AU - Robert,M, AU - Boularan,A M, AU - Delbos,O, AU - Guiter,J, AU - Descomps,B, PY - 1998/3/31/pubmed PY - 2000/10/6/medline PY - 1998/3/31/entrez SP - 41 EP - 6 JF - Urologia internationalis JO - Urol. Int. VL - 60 IS - 1 N2 - OBJECTIVE: The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS: Urine specimens were directly collected from the bladder and the kidney, of 11 stone formers and 11 control subjects under general anesthesia. The type of crystals present in urine as well as their size, number by cubic millimeter and state of aggregation were determined. In addition, calcium, magnesium, sodium, chloride, phosphate, citrate, oxalate, pyrophosphate and uric acid were measured in order to evaluate the calcium saturation status (EQUIL V program). RESULTS: Calcium oxalate crystals were detected in 3 stone formers (27%) and 2 control subjects (18%) in vesical urine and in 4 stone formers (36%) and 3 control subjects (27%) in renal urine. Only 2 stone formers presented with simultaneous renal and vesical crystalluria. Subjects of the two groups with and without renal crystalluria were compared in terms of chemical composition and calcium oxalate saturation of renal urine. Crystalluric subjects (n = 7) had significantly higher uricosuria (p = 0.02), calciuria (p = 0.04), magnesiuria (p = 0.04) and calcium oxalate molar product (p = 0.05) than noncrystalluric (n = 15); calcium oxalate saturation was similar (p = 0.5). CONCLUSIONS: Beyond theorical considerations on lithogenesis, our observations and in particular the apparent discrepancy between renal and vesical crystalluria pose the problem of the clinical interest of the evaluation of calcium oxalate crystalluria based on freshly voided urine in the assessing the lithogenic risk or in the follow-up of patients who are particularly prone to stone recurrence. SN - 0042-1138 UR - https://www.unboundmedicine.com/medline/citation/9519420/Study_of_calcium_oxalate_crystalluria_on_renal_and_vesical_urines_in_stone_formers_and_normal_subjects_ L2 - https://www.karger.com?DOI=10.1159/000030201 DB - PRIME DP - Unbound Medicine ER -