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Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects.

Abstract

OBJECTIVE

The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine.

MATERIAL AND METHODS

Urine specimens were directly collected from the bladder and the kidney, of 11 stone formers and 11 control subjects under general anesthesia. The type of crystals present in urine as well as their size, number by cubic millimeter and state of aggregation were determined. In addition, calcium, magnesium, sodium, chloride, phosphate, citrate, oxalate, pyrophosphate and uric acid were measured in order to evaluate the calcium saturation status (EQUIL V program).

RESULTS

Calcium oxalate crystals were detected in 3 stone formers (27%) and 2 control subjects (18%) in vesical urine and in 4 stone formers (36%) and 3 control subjects (27%) in renal urine. Only 2 stone formers presented with simultaneous renal and vesical crystalluria. Subjects of the two groups with and without renal crystalluria were compared in terms of chemical composition and calcium oxalate saturation of renal urine. Crystalluric subjects (n = 7) had significantly higher uricosuria (p = 0.02), calciuria (p = 0.04), magnesiuria (p = 0.04) and calcium oxalate molar product (p = 0.05) than noncrystalluric (n = 15); calcium oxalate saturation was similar (p = 0.5).

CONCLUSIONS

Beyond theorical considerations on lithogenesis, our observations and in particular the apparent discrepancy between renal and vesical crystalluria pose the problem of the clinical interest of the evaluation of calcium oxalate crystalluria based on freshly voided urine in the assessing the lithogenic risk or in the follow-up of patients who are particularly prone to stone recurrence.

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  • Authors+Show Affiliations

    ,

    Department of Urology, Lapeyronie University Hospital, Montpellier, France.

    , , ,

    Source

    Urologia internationalis 60:1 1998 pg 41-6

    MeSH

    Adult
    Aged
    Calcium Oxalate
    Crystallization
    Female
    Humans
    Incidence
    Kidney Calculi
    Male
    Middle Aged
    Reference Values
    Urinalysis
    Urinary Bladder Calculi
    Urine

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Controlled Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    9519420

    Citation

    Robert, M, et al. "Study of Calcium Oxalate Crystalluria On Renal and Vesical Urines in Stone Formers and Normal Subjects." Urologia Internationalis, vol. 60, no. 1, 1998, pp. 41-6.
    Robert M, Boularan AM, Delbos O, et al. Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. Urol Int. 1998;60(1):41-6.
    Robert, M., Boularan, A. M., Delbos, O., Guiter, J., & Descomps, B. (1998). Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. Urologia Internationalis, 60(1), pp. 41-6.
    Robert M, et al. Study of Calcium Oxalate Crystalluria On Renal and Vesical Urines in Stone Formers and Normal Subjects. Urol Int. 1998;60(1):41-6. PubMed PMID: 9519420.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Study of calcium oxalate crystalluria on renal and vesical urines in stone formers and normal subjects. AU - Robert,M, AU - Boularan,A M, AU - Delbos,O, AU - Guiter,J, AU - Descomps,B, PY - 1998/3/31/pubmed PY - 2000/10/6/medline PY - 1998/3/31/entrez SP - 41 EP - 6 JF - Urologia internationalis JO - Urol. Int. VL - 60 IS - 1 N2 - OBJECTIVE: The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS: Urine specimens were directly collected from the bladder and the kidney, of 11 stone formers and 11 control subjects under general anesthesia. The type of crystals present in urine as well as their size, number by cubic millimeter and state of aggregation were determined. In addition, calcium, magnesium, sodium, chloride, phosphate, citrate, oxalate, pyrophosphate and uric acid were measured in order to evaluate the calcium saturation status (EQUIL V program). RESULTS: Calcium oxalate crystals were detected in 3 stone formers (27%) and 2 control subjects (18%) in vesical urine and in 4 stone formers (36%) and 3 control subjects (27%) in renal urine. Only 2 stone formers presented with simultaneous renal and vesical crystalluria. Subjects of the two groups with and without renal crystalluria were compared in terms of chemical composition and calcium oxalate saturation of renal urine. Crystalluric subjects (n = 7) had significantly higher uricosuria (p = 0.02), calciuria (p = 0.04), magnesiuria (p = 0.04) and calcium oxalate molar product (p = 0.05) than noncrystalluric (n = 15); calcium oxalate saturation was similar (p = 0.5). CONCLUSIONS: Beyond theorical considerations on lithogenesis, our observations and in particular the apparent discrepancy between renal and vesical crystalluria pose the problem of the clinical interest of the evaluation of calcium oxalate crystalluria based on freshly voided urine in the assessing the lithogenic risk or in the follow-up of patients who are particularly prone to stone recurrence. SN - 0042-1138 UR - https://www.unboundmedicine.com/medline/citation/9519420/Study_of_calcium_oxalate_crystalluria_on_renal_and_vesical_urines_in_stone_formers_and_normal_subjects_ L2 - https://www.karger.com?DOI=10.1159/000030201 DB - PRIME DP - Unbound Medicine ER -