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4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion.
Diabetes. 1998 Feb; 47(2):206-10.D

Abstract

We report the characterization of a new insulinotropic compound, 4-hydroxyisoleucine. This amino acid has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties. 4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans. The stimulating effect of 4-hydroxyisoleucine was strictly glucose dependent; indeed, ineffective at low (3 mmol/l) or basal (5 mmol/l) glucose concentrations, the amino acid potentiated the insulin secretion induced by supranormal (6.6-16.7 mmol/l) concentrations of glucose. In addition, in the isolated perfused rat pancreas, we could show 1) that the pattern of insulin secretion induced by 4-hydroxyisoleucine was biphasic, 2) that this effect occurred in the absence of any change in pancreatic alpha- and delta-cell activity, and 3) that the more glucose concentration was increased, the more insulin response was amplified. Moreover, 4-hydroxyisoleucine did not interact with other agonists of insulin secretion (leucine, arginine, tolbutamide, glyceraldehyde). Therefore, we conclude that 4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties. This secretagogue may be considered as a novel drug with potential interest for the treatment of NIDDM.

Authors+Show Affiliations

Laboratoire de Recherche sur les Substances Naturelles Végétales, Université Montpellier II, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9519714

Citation

Sauvaire, Y, et al. "4-Hydroxyisoleucine: a Novel Amino Acid Potentiator of Insulin Secretion." Diabetes, vol. 47, no. 2, 1998, pp. 206-10.
Sauvaire Y, Petit P, Broca C, et al. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes. 1998;47(2):206-10.
Sauvaire, Y., Petit, P., Broca, C., Manteghetti, M., Baissac, Y., Fernandez-Alvarez, J., Gross, R., Roye, M., Leconte, A., Gomis, R., & Ribes, G. (1998). 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes, 47(2), 206-10.
Sauvaire Y, et al. 4-Hydroxyisoleucine: a Novel Amino Acid Potentiator of Insulin Secretion. Diabetes. 1998;47(2):206-10. PubMed PMID: 9519714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. AU - Sauvaire,Y, AU - Petit,P, AU - Broca,C, AU - Manteghetti,M, AU - Baissac,Y, AU - Fernandez-Alvarez,J, AU - Gross,R, AU - Roye,M, AU - Leconte,A, AU - Gomis,R, AU - Ribes,G, PY - 1998/3/31/pubmed PY - 1998/3/31/medline PY - 1998/3/31/entrez SP - 206 EP - 10 JF - Diabetes JO - Diabetes VL - 47 IS - 2 N2 - We report the characterization of a new insulinotropic compound, 4-hydroxyisoleucine. This amino acid has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties. 4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans. The stimulating effect of 4-hydroxyisoleucine was strictly glucose dependent; indeed, ineffective at low (3 mmol/l) or basal (5 mmol/l) glucose concentrations, the amino acid potentiated the insulin secretion induced by supranormal (6.6-16.7 mmol/l) concentrations of glucose. In addition, in the isolated perfused rat pancreas, we could show 1) that the pattern of insulin secretion induced by 4-hydroxyisoleucine was biphasic, 2) that this effect occurred in the absence of any change in pancreatic alpha- and delta-cell activity, and 3) that the more glucose concentration was increased, the more insulin response was amplified. Moreover, 4-hydroxyisoleucine did not interact with other agonists of insulin secretion (leucine, arginine, tolbutamide, glyceraldehyde). Therefore, we conclude that 4-hydroxyisoleucine insulinotropic activity might, at least in part, account for fenugreek seeds' antidiabetic properties. This secretagogue may be considered as a novel drug with potential interest for the treatment of NIDDM. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/9519714/4_Hydroxyisoleucine:_a_novel_amino_acid_potentiator_of_insulin_secretion_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&pmid=9519714 DB - PRIME DP - Unbound Medicine ER -