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Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia.
Clin Genet 1997; 52(5):408-13CG

Abstract

The apolipoprotein E (APOE) epsilon4 allele is a risk factor in Alzheimer disease (AD), but not in vascular dementia (VaD). We have investigated whether the epsilon4 allele is more common in twin pairs concordant for AD, compared with those discordant for AD, and whether the epsilon4 allele is more common in AD twins than in VaD twins. In addition, we have investigated the relationship of the epsilon4 allele and the age at onset in AD and VaD. APOE genotype was analysed in 29 senile demented twin pairs. The epsilon4 allele was associated with AD and not with VaD. However, there was no difference in the frequency of the APOE epsilon4 allele in concordant (33.3%) and discordant (31.3%) AD dizygotic twin pairs. Age at onset in AD was significantly lower in epsilon4 homozygotes than in individuals with one or no copies of epsilon4 (62.4 vs. 73.5, p<0.01). In concordant AD twin pairs, the epsilon4 allele frequency was somewhat higher in the twins with earlier onset (41.7% vs. 25%), but the difference was not statistically significant. In the VaD group the age at onset was not significantly different between individuals with or without epsilon4 in their genotypes.

Authors+Show Affiliations

Department of Psychiatry, University of Oslo, Vinderen, Norway.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9520135

Citation

Bergem, A L., and L Lannfelt. "Apolipoprotein E Type Epsilon4 Allele, Heritability and Age at Onset in Twins With Alzheimer Disease and Vascular Dementia." Clinical Genetics, vol. 52, no. 5, 1997, pp. 408-13.
Bergem AL, Lannfelt L. Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. Clin Genet. 1997;52(5):408-13.
Bergem, A. L., & Lannfelt, L. (1997). Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. Clinical Genetics, 52(5), pp. 408-13.
Bergem AL, Lannfelt L. Apolipoprotein E Type Epsilon4 Allele, Heritability and Age at Onset in Twins With Alzheimer Disease and Vascular Dementia. Clin Genet. 1997;52(5):408-13. PubMed PMID: 9520135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia. AU - Bergem,A L, AU - Lannfelt,L, PY - 1998/3/31/pubmed PY - 1998/3/31/medline PY - 1998/3/31/entrez SP - 408 EP - 13 JF - Clinical genetics JO - Clin. Genet. VL - 52 IS - 5 N2 - The apolipoprotein E (APOE) epsilon4 allele is a risk factor in Alzheimer disease (AD), but not in vascular dementia (VaD). We have investigated whether the epsilon4 allele is more common in twin pairs concordant for AD, compared with those discordant for AD, and whether the epsilon4 allele is more common in AD twins than in VaD twins. In addition, we have investigated the relationship of the epsilon4 allele and the age at onset in AD and VaD. APOE genotype was analysed in 29 senile demented twin pairs. The epsilon4 allele was associated with AD and not with VaD. However, there was no difference in the frequency of the APOE epsilon4 allele in concordant (33.3%) and discordant (31.3%) AD dizygotic twin pairs. Age at onset in AD was significantly lower in epsilon4 homozygotes than in individuals with one or no copies of epsilon4 (62.4 vs. 73.5, p<0.01). In concordant AD twin pairs, the epsilon4 allele frequency was somewhat higher in the twins with earlier onset (41.7% vs. 25%), but the difference was not statistically significant. In the VaD group the age at onset was not significantly different between individuals with or without epsilon4 in their genotypes. SN - 0009-9163 UR - https://www.unboundmedicine.com/medline/citation/9520135/Apolipoprotein_E_type_epsilon4_allele_heritability_and_age_at_onset_in_twins_with_Alzheimer_disease_and_vascular_dementia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0009-9163&amp;date=1997&amp;volume=52&amp;issue=5&amp;spage=408 DB - PRIME DP - Unbound Medicine ER -