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International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting.
Eur J Anaesthesiol. 1998 Jan; 15(1):69-79.EJ

Abstract

Ondansetron 4 mg was compared with metoclopramide 10 mg for prevention of post-operative nausea and emesis in in-patients undergoing major gynaecological surgery in this double-blind, randomized, placebo-controlled, multicentre study. A total of 1044 patients received a single intravenous (i.v.) injection of study medication immediately before induction of anaesthesia. Nausea and emesis were assessed over the 24 h post-operative period. Significantly more patients who received ondansetron experienced no emetic episodes (44%) compared with those who received metoclopramide (37%, P = 0.049) or placebo (25%, P < 0.001). No nausea was experienced by significantly more patients who received ondansetron (32%) than with patients who received metoclopramide (24%, P = 0.009) or placebo (16%, P < 0.001). In addition, fewer emetic episodes, less severe nausea and a reduced need for rescue antiemetics were also observed with ondansetron (P < 0.05 vs. metoclopramide and placebo). Metoclopramide and placebo-treated patients were also 1.5 times (95% Cl 1.5-4.2) and 2.5 times (95% Cl 1.1-2.0) more likely, respectively, to experience nausea post-operatively. Overall, ondansetron was the most effective antiemetic in this patient population.

Authors+Show Affiliations

Department of Anaesthetics, Princess of Wales Hospital, Bridgend, Mid Glamorgan, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

9522145

Citation

Morris, R W., et al. "International, Multicentre, Placebo-controlled Study to Evaluate the Effectiveness of Ondansetron Vs. Metoclopramide in the Prevention of Post-operative Nausea and Vomiting." European Journal of Anaesthesiology, vol. 15, no. 1, 1998, pp. 69-79.
Morris RW, Aune H, Feiss P, et al. International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting. Eur J Anaesthesiol. 1998;15(1):69-79.
Morris, R. W., Aune, H., Feiss, P., Hanson, A., Hasselstrøm, L., Maltby, J. R., Rocke, D. A., Rozenberg, B., Rust, M., & Cohen, L. A. (1998). International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting. European Journal of Anaesthesiology, 15(1), 69-79.
Morris RW, et al. International, Multicentre, Placebo-controlled Study to Evaluate the Effectiveness of Ondansetron Vs. Metoclopramide in the Prevention of Post-operative Nausea and Vomiting. Eur J Anaesthesiol. 1998;15(1):69-79. PubMed PMID: 9522145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting. AU - Morris,R W, AU - Aune,H, AU - Feiss,P, AU - Hanson,A, AU - Hasselstrøm,L, AU - Maltby,J R, AU - Rocke,D A, AU - Rozenberg,B, AU - Rust,M, AU - Cohen,L A, PY - 1998/4/2/pubmed PY - 1998/4/2/medline PY - 1998/4/2/entrez SP - 69 EP - 79 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 15 IS - 1 N2 - Ondansetron 4 mg was compared with metoclopramide 10 mg for prevention of post-operative nausea and emesis in in-patients undergoing major gynaecological surgery in this double-blind, randomized, placebo-controlled, multicentre study. A total of 1044 patients received a single intravenous (i.v.) injection of study medication immediately before induction of anaesthesia. Nausea and emesis were assessed over the 24 h post-operative period. Significantly more patients who received ondansetron experienced no emetic episodes (44%) compared with those who received metoclopramide (37%, P = 0.049) or placebo (25%, P < 0.001). No nausea was experienced by significantly more patients who received ondansetron (32%) than with patients who received metoclopramide (24%, P = 0.009) or placebo (16%, P < 0.001). In addition, fewer emetic episodes, less severe nausea and a reduced need for rescue antiemetics were also observed with ondansetron (P < 0.05 vs. metoclopramide and placebo). Metoclopramide and placebo-treated patients were also 1.5 times (95% Cl 1.5-4.2) and 2.5 times (95% Cl 1.1-2.0) more likely, respectively, to experience nausea post-operatively. Overall, ondansetron was the most effective antiemetic in this patient population. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/9522145/International_multicentre_placebo_controlled_study_to_evaluate_the_effectiveness_of_ondansetron_vs__metoclopramide_in_the_prevention_of_post_operative_nausea_and_vomiting_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9522145.ui DB - PRIME DP - Unbound Medicine ER -