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Central motor pathway evaluation using magnetic coil stimulation in hereditary motor and sensory neuropathy type I (HMSN type I, Charcot-Marie-Tooth disease).
Int J Neurosci. 1997 Dec; 92(3-4):145-59.IJ

Abstract

Central Motor Conduction Time (CMCT) was investigated in 18 patients (5 m, 13 f; age range: 11-69 yrs) with clinical and electrophysiological features of HMSN type I, using Magnetic Coil (MC) stimulation. No one exhibited clinically pyramidal signs. Brain stimulation Motor Evoked Potentials (MEPs), recorded monolaterally from the left abductor digiti minimi (ADM) and tibialis anterior (TA) muscles, were evoked in all patients from upper extremities and absent in 11.1% from lower limbs. Total Motor Conduction Time (TMCT), as well as Peripheral Motor Conduction Time estimated by either magnetic nerve root stimulation (mag-PMCT) or F-wave latency values (F-PMCT), were markedly delayed in all patients. Central Motor Conduction Time was calculated by subtracting both the latency of mag-PMCT (mag-CMCT) and F-PMCT (F-CMCT) from that one obtained by cortical stimulation. F-CMCT was abnormal in 22.2% in upper extremities and in 27.8% patients from lower extremities, whereas mag-CMCT in 22.2% from ADM muscles and in 33.3% from TA muscles. Furthermore, CMCT to both methods was not possible to evaluate in 5.6% from upper and lower extremities and following magnetic root stimulation in 11.1% from lower limbs. These findings prove lower motor neuron involvement, in agreement with electroneurographic data, and suggest a possible central motor pathways impairment, even in patients without any clinical evidence, but they cannot explain which is the underlying pathophysiological mechanism, a true upper motor neuron involvement or an abnormal spinal motor neuron excitability.

Authors+Show Affiliations

Department of Neurosciences, University of Pisa, Italy. F.Sartucci@neuro.med.unipi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9522263

Citation

Sartucci, F, et al. "Central Motor Pathway Evaluation Using Magnetic Coil Stimulation in Hereditary Motor and Sensory Neuropathy Type I (HMSN Type I, Charcot-Marie-Tooth Disease)." The International Journal of Neuroscience, vol. 92, no. 3-4, 1997, pp. 145-59.
Sartucci F, Sagliocco L, Murri L. Central motor pathway evaluation using magnetic coil stimulation in hereditary motor and sensory neuropathy type I (HMSN type I, Charcot-Marie-Tooth disease). Int J Neurosci. 1997;92(3-4):145-59.
Sartucci, F., Sagliocco, L., & Murri, L. (1997). Central motor pathway evaluation using magnetic coil stimulation in hereditary motor and sensory neuropathy type I (HMSN type I, Charcot-Marie-Tooth disease). The International Journal of Neuroscience, 92(3-4), 145-59.
Sartucci F, Sagliocco L, Murri L. Central Motor Pathway Evaluation Using Magnetic Coil Stimulation in Hereditary Motor and Sensory Neuropathy Type I (HMSN Type I, Charcot-Marie-Tooth Disease). Int J Neurosci. 1997;92(3-4):145-59. PubMed PMID: 9522263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central motor pathway evaluation using magnetic coil stimulation in hereditary motor and sensory neuropathy type I (HMSN type I, Charcot-Marie-Tooth disease). AU - Sartucci,F, AU - Sagliocco,L, AU - Murri,L, PY - 1998/4/2/pubmed PY - 1998/4/2/medline PY - 1998/4/2/entrez SP - 145 EP - 59 JF - The International journal of neuroscience JO - Int J Neurosci VL - 92 IS - 3-4 N2 - Central Motor Conduction Time (CMCT) was investigated in 18 patients (5 m, 13 f; age range: 11-69 yrs) with clinical and electrophysiological features of HMSN type I, using Magnetic Coil (MC) stimulation. No one exhibited clinically pyramidal signs. Brain stimulation Motor Evoked Potentials (MEPs), recorded monolaterally from the left abductor digiti minimi (ADM) and tibialis anterior (TA) muscles, were evoked in all patients from upper extremities and absent in 11.1% from lower limbs. Total Motor Conduction Time (TMCT), as well as Peripheral Motor Conduction Time estimated by either magnetic nerve root stimulation (mag-PMCT) or F-wave latency values (F-PMCT), were markedly delayed in all patients. Central Motor Conduction Time was calculated by subtracting both the latency of mag-PMCT (mag-CMCT) and F-PMCT (F-CMCT) from that one obtained by cortical stimulation. F-CMCT was abnormal in 22.2% in upper extremities and in 27.8% patients from lower extremities, whereas mag-CMCT in 22.2% from ADM muscles and in 33.3% from TA muscles. Furthermore, CMCT to both methods was not possible to evaluate in 5.6% from upper and lower extremities and following magnetic root stimulation in 11.1% from lower limbs. These findings prove lower motor neuron involvement, in agreement with electroneurographic data, and suggest a possible central motor pathways impairment, even in patients without any clinical evidence, but they cannot explain which is the underlying pathophysiological mechanism, a true upper motor neuron involvement or an abnormal spinal motor neuron excitability. SN - 0020-7454 UR - https://www.unboundmedicine.com/medline/citation/9522263/Central_motor_pathway_evaluation_using_magnetic_coil_stimulation_in_hereditary_motor_and_sensory_neuropathy_type_I__HMSN_type_I_Charcot_Marie_Tooth_disease__ L2 - https://www.tandfonline.com/doi/full/10.3109/00207459708986398 DB - PRIME DP - Unbound Medicine ER -