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Pharmacological prevention of migraine.
Clin Neurosci. 1998; 5(1):55-9.CN

Abstract

Although abortive treatment and nonpharmacologic interventions are effective for many if not most patients' occasional migraine attacks, patients who have frequent and/or severe attacks may benefit from preventive pharmacotherapy. This is particularly critical for those patients whose migraines are not treated effectively by acute-care medications because lack of pain control may lead to overuse syndromes that complicate further treatment. Inappropriate use of acute-care medication may contribute to chronic daily headache, tolerance to symptomatic medication, and headache refractory to all treatment. In addition, patients who increase use of acute-care medication due to lack of effect may suffer ergotism, GI problems, liver toxicity, analgesic nephropathy, drug induced-headache, and withdrawal symptoms when overused agents are withdrawn. Finally, overuse of acute-care medication may interfere with the effectiveness of preventive medication. The remainder of this article will focus on when to treat with preventive medication and which medications are currently available for prevention of migraine.

Authors+Show Affiliations

Rapoport AM
Yale University School of Medicine, New Haven, Connecticut, USA.

MeSH

Adrenergic beta-AntagonistsAnti-Inflammatory Agents, Non-SteroidalAnticonvulsantsAntidepressive AgentsCalcium Channel BlockersHumansMigraine DisordersSerotonin AntagonistsValproic Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9523060

Citation

Rapoport, A M.. "Pharmacological Prevention of Migraine." Clinical Neuroscience (New York, N.Y.), vol. 5, no. 1, 1998, pp. 55-9.
Rapoport AM. Pharmacological prevention of migraine. Clin Neurosci. 1998;5(1):55-9.
Rapoport, A. M. (1998). Pharmacological prevention of migraine. Clinical Neuroscience (New York, N.Y.), 5(1), 55-9.
Rapoport AM. Pharmacological Prevention of Migraine. Clin Neurosci. 1998;5(1):55-9. PubMed PMID: 9523060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological prevention of migraine. A1 - Rapoport,A M, PY - 1998/4/2/pubmed PY - 1998/4/2/medline PY - 1998/4/2/entrez SP - 55 EP - 9 JF - Clinical neuroscience (New York, N.Y.) JO - Clin. Neurosci. VL - 5 IS - 1 N2 - Although abortive treatment and nonpharmacologic interventions are effective for many if not most patients' occasional migraine attacks, patients who have frequent and/or severe attacks may benefit from preventive pharmacotherapy. This is particularly critical for those patients whose migraines are not treated effectively by acute-care medications because lack of pain control may lead to overuse syndromes that complicate further treatment. Inappropriate use of acute-care medication may contribute to chronic daily headache, tolerance to symptomatic medication, and headache refractory to all treatment. In addition, patients who increase use of acute-care medication due to lack of effect may suffer ergotism, GI problems, liver toxicity, analgesic nephropathy, drug induced-headache, and withdrawal symptoms when overused agents are withdrawn. Finally, overuse of acute-care medication may interfere with the effectiveness of preventive medication. The remainder of this article will focus on when to treat with preventive medication and which medications are currently available for prevention of migraine. SN - 1065-6766 UR - https://www.unboundmedicine.com/medline/citation/9523060/Pharmacological_prevention_of_migraine_ L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -