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Pathology of practolol-induced ocular toxicity.

Abstract

The ocular side-effects of prolonged practolol administration concern the cornea and conjunctiva and are related to deficient tear secretion and the formation of an autoantibody which has an affinity for the intercellular zones of squanmous epithelium. Histopathological study of six cases, including a review of the necropsy findings in two, showed destruction of lacrimal gland tissue, epidermalization of the conjunctival epithelium, with epitheliolysis and stromal ulceration of the cornea leading to perforation in two patients. Immunoperoxidase studies showed fixation of specific antibody in the corneal and conjunctival epithelium but, in the one case in which the tissue could be adequately studied, complement fixation could not be demonstrated. Possibly, therefore, the immune response in patients with practolol-induced ocular damage is secondary to the epithelial disturbance rather than its cause.

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  • Authors

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    Source

    The British journal of ophthalmology 60:5 1976 May pg 312-23

    MeSH

    Aged
    Angina Pectoris
    Conjunctiva
    Cornea
    Epithelium
    Eye
    Eye Diseases
    Female
    Humans
    Hypertension
    Immunoglobulins
    Lacrimal Apparatus
    Male
    Microscopy, Electron
    Middle Aged
    Myocardial Infarction
    Practolol

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    952801

    Citation

    Rahi, A H., et al. "Pathology of Practolol-induced Ocular Toxicity." The British Journal of Ophthalmology, vol. 60, no. 5, 1976, pp. 312-23.
    Rahi AH, Chapman CM, Garner A, et al. Pathology of practolol-induced ocular toxicity. Br J Ophthalmol. 1976;60(5):312-23.
    Rahi, A. H., Chapman, C. M., Garner, A., & Wright, P. (1976). Pathology of practolol-induced ocular toxicity. The British Journal of Ophthalmology, 60(5), pp. 312-23.
    Rahi AH, et al. Pathology of Practolol-induced Ocular Toxicity. Br J Ophthalmol. 1976;60(5):312-23. PubMed PMID: 952801.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pathology of practolol-induced ocular toxicity. AU - Rahi,A H, AU - Chapman,C M, AU - Garner,A, AU - Wright,P, PY - 1976/5/1/pubmed PY - 1976/5/1/medline PY - 1976/5/1/entrez SP - 312 EP - 23 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 60 IS - 5 N2 - The ocular side-effects of prolonged practolol administration concern the cornea and conjunctiva and are related to deficient tear secretion and the formation of an autoantibody which has an affinity for the intercellular zones of squanmous epithelium. Histopathological study of six cases, including a review of the necropsy findings in two, showed destruction of lacrimal gland tissue, epidermalization of the conjunctival epithelium, with epitheliolysis and stromal ulceration of the cornea leading to perforation in two patients. Immunoperoxidase studies showed fixation of specific antibody in the corneal and conjunctival epithelium but, in the one case in which the tissue could be adequately studied, complement fixation could not be demonstrated. Possibly, therefore, the immune response in patients with practolol-induced ocular damage is secondary to the epithelial disturbance rather than its cause. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/952801/Pathology_of_practolol_induced_ocular_toxicity_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=952801 DB - PRIME DP - Unbound Medicine ER -