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Pathology of practolol-induced ocular toxicity.
Br J Ophthalmol 1976; 60(5):312-23BJ

Abstract

The ocular side-effects of prolonged practolol administration concern the cornea and conjunctiva and are related to deficient tear secretion and the formation of an autoantibody which has an affinity for the intercellular zones of squanmous epithelium. Histopathological study of six cases, including a review of the necropsy findings in two, showed destruction of lacrimal gland tissue, epidermalization of the conjunctival epithelium, with epitheliolysis and stromal ulceration of the cornea leading to perforation in two patients. Immunoperoxidase studies showed fixation of specific antibody in the corneal and conjunctival epithelium but, in the one case in which the tissue could be adequately studied, complement fixation could not be demonstrated. Possibly, therefore, the immune response in patients with practolol-induced ocular damage is secondary to the epithelial disturbance rather than its cause.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

952801

Citation

Rahi, A H., et al. "Pathology of Practolol-induced Ocular Toxicity." The British Journal of Ophthalmology, vol. 60, no. 5, 1976, pp. 312-23.
Rahi AH, Chapman CM, Garner A, et al. Pathology of practolol-induced ocular toxicity. Br J Ophthalmol. 1976;60(5):312-23.
Rahi, A. H., Chapman, C. M., Garner, A., & Wright, P. (1976). Pathology of practolol-induced ocular toxicity. The British Journal of Ophthalmology, 60(5), pp. 312-23.
Rahi AH, et al. Pathology of Practolol-induced Ocular Toxicity. Br J Ophthalmol. 1976;60(5):312-23. PubMed PMID: 952801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathology of practolol-induced ocular toxicity. AU - Rahi,A H, AU - Chapman,C M, AU - Garner,A, AU - Wright,P, PY - 1976/5/1/pubmed PY - 1976/5/1/medline PY - 1976/5/1/entrez SP - 312 EP - 23 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 60 IS - 5 N2 - The ocular side-effects of prolonged practolol administration concern the cornea and conjunctiva and are related to deficient tear secretion and the formation of an autoantibody which has an affinity for the intercellular zones of squanmous epithelium. Histopathological study of six cases, including a review of the necropsy findings in two, showed destruction of lacrimal gland tissue, epidermalization of the conjunctival epithelium, with epitheliolysis and stromal ulceration of the cornea leading to perforation in two patients. Immunoperoxidase studies showed fixation of specific antibody in the corneal and conjunctival epithelium but, in the one case in which the tissue could be adequately studied, complement fixation could not be demonstrated. Possibly, therefore, the immune response in patients with practolol-induced ocular damage is secondary to the epithelial disturbance rather than its cause. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/952801/Pathology_of_practolol_induced_ocular_toxicity_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=952801 DB - PRIME DP - Unbound Medicine ER -