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Apolipoprotein E polymorphism in elderly east Africans.
East Afr Med J 1997; 74(10):668-70EA

Abstract

Current advances have shown the apolipoprotein E (APOE)-epsilon 4 allele to be highly associated with late-onset familial and sporadic Alzheimer's disease (AD) in Western populations. The association of APOE allele frequencies and dementia remain unknown in populations from developing countries. We recently initiated a project to examine APOE frequencies in non-demented and demented elderly East Africans. Blood DNA collected from two hospital-based populations showed that the APOE allele frequencies in a group of non-demented 67 Tanzanians over the age of 65 years were found to be 14% for epsilon 2, 61% for epsilon 3 and 25% for epsilon 4. By comparison, the frequency of APOE-epsilon 4 in an age-matched demented group was also 25%. Assessment of APOE genotypes in the group of elderly Kenyan subjects from Nairobi also revealed high frequencies of the epsilon 4 allele with no clear difference in frequency between demented and non-demented subjects. Our preliminary observations suggest that elderly East Africans with no apparent clinical AD possess relatively high APOE-epsilon 4 allele frequencies compared to normal ageing subjects from Western countries including African-Americans. These results appear similar to those reported in a recent study in Nigerian Africans where a lack of correlation between APOE-epsilon 4 allele frequency and Alzheimer type of dementia was noted, and imply that APOE-epsilon 4 allele may not necessarily be a risk factor in some populations of Africa.

Authors+Show Affiliations

Department of Neurological Surgery (BRD5), Case Western Reserve University, Cleveland, Ohio 44106-4938, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9529753

Citation

Sayi, J G., et al. "Apolipoprotein E Polymorphism in Elderly East Africans." East African Medical Journal, vol. 74, no. 10, 1997, pp. 668-70.
Sayi JG, Patel NB, Premkumar DR, et al. Apolipoprotein E polymorphism in elderly east Africans. East Afr Med J. 1997;74(10):668-70.
Sayi, J. G., Patel, N. B., Premkumar, D. R., Adem, A., Winblad, B., Matuja, W. B., ... Kalaria, R. N. (1997). Apolipoprotein E polymorphism in elderly east Africans. East African Medical Journal, 74(10), pp. 668-70.
Sayi JG, et al. Apolipoprotein E Polymorphism in Elderly East Africans. East Afr Med J. 1997;74(10):668-70. PubMed PMID: 9529753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism in elderly east Africans. AU - Sayi,J G, AU - Patel,N B, AU - Premkumar,D R, AU - Adem,A, AU - Winblad,B, AU - Matuja,W B, AU - Mtui,E P, AU - Gatere,S, AU - Friedland,R P, AU - Koss,E, AU - Kalaria,R N, PY - 1998/4/8/pubmed PY - 1998/4/8/medline PY - 1998/4/8/entrez SP - 668 EP - 70 JF - East African medical journal JO - East Afr Med J VL - 74 IS - 10 N2 - Current advances have shown the apolipoprotein E (APOE)-epsilon 4 allele to be highly associated with late-onset familial and sporadic Alzheimer's disease (AD) in Western populations. The association of APOE allele frequencies and dementia remain unknown in populations from developing countries. We recently initiated a project to examine APOE frequencies in non-demented and demented elderly East Africans. Blood DNA collected from two hospital-based populations showed that the APOE allele frequencies in a group of non-demented 67 Tanzanians over the age of 65 years were found to be 14% for epsilon 2, 61% for epsilon 3 and 25% for epsilon 4. By comparison, the frequency of APOE-epsilon 4 in an age-matched demented group was also 25%. Assessment of APOE genotypes in the group of elderly Kenyan subjects from Nairobi also revealed high frequencies of the epsilon 4 allele with no clear difference in frequency between demented and non-demented subjects. Our preliminary observations suggest that elderly East Africans with no apparent clinical AD possess relatively high APOE-epsilon 4 allele frequencies compared to normal ageing subjects from Western countries including African-Americans. These results appear similar to those reported in a recent study in Nigerian Africans where a lack of correlation between APOE-epsilon 4 allele frequency and Alzheimer type of dementia was noted, and imply that APOE-epsilon 4 allele may not necessarily be a risk factor in some populations of Africa. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/9529753/Apolipoprotein_E_polymorphism_in_elderly_east_Africans_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -