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[Influence of antilymphocyte sera on the development of experimental allergic encephalomyelitis].
Biull Eksp Biol Med. 1976 Jul; 82(7):844-7.BE

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs by sensitization of myelinomas of homologous or heterologous (rabbit) brain in the complete Freund's adjuvant. Antilymphocytic serum (ALS) obtained by immunization of rabbits with the lymphocytes of the lymph nodes of guinea pigs was injected subcutaneously for 3--6 days at the early periods before or after the sensitization. ALS produced a marked inhibitory action on the development of the neurological signs of EAE and of histological changes in the form of demyelinization and perivascular cell infiltration in the lumbo-sacral and cervical portions of the spinal cord. Administration of ALS beginning from the 3rd--5th day before the sensitization or from the date of the EAE induction proved to be the most effective. When the injections were started from the 7th or the 12th day after the sensitization an increase in the incidence of the disease occurred in the grooups. A fall of morbidity correlated with a reduction of percentage of positive skin tests in response to the intradermal injection of a homologous myelin. No reduction in the production of the complement-fixing, antibodies to the heterologous antigen was seen in the animals given ALS. This pointed to the participation of cell factors in the development of the pathological process.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

953349

Citation

Zhitnukhin, Iu L., and M N. Baĭkovskaia. "[Influence of Antilymphocyte Sera On the Development of Experimental Allergic Encephalomyelitis]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 82, no. 7, 1976, pp. 844-7.
Zhitnukhin IuL, Baĭkovskaia MN. [Influence of antilymphocyte sera on the development of experimental allergic encephalomyelitis]. Biull Eksp Biol Med. 1976;82(7):844-7.
Zhitnukhin, I. u. L., & Baĭkovskaia, M. N. (1976). [Influence of antilymphocyte sera on the development of experimental allergic encephalomyelitis]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 82(7), 844-7.
Zhitnukhin IuL, Baĭkovskaia MN. [Influence of Antilymphocyte Sera On the Development of Experimental Allergic Encephalomyelitis]. Biull Eksp Biol Med. 1976;82(7):844-7. PubMed PMID: 953349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of antilymphocyte sera on the development of experimental allergic encephalomyelitis]. AU - Zhitnukhin,Iu L, AU - Baĭkovskaia,M N, PY - 1976/7/1/pubmed PY - 1976/7/1/medline PY - 1976/7/1/entrez SP - 844 EP - 7 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 82 IS - 7 N2 - Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs by sensitization of myelinomas of homologous or heterologous (rabbit) brain in the complete Freund's adjuvant. Antilymphocytic serum (ALS) obtained by immunization of rabbits with the lymphocytes of the lymph nodes of guinea pigs was injected subcutaneously for 3--6 days at the early periods before or after the sensitization. ALS produced a marked inhibitory action on the development of the neurological signs of EAE and of histological changes in the form of demyelinization and perivascular cell infiltration in the lumbo-sacral and cervical portions of the spinal cord. Administration of ALS beginning from the 3rd--5th day before the sensitization or from the date of the EAE induction proved to be the most effective. When the injections were started from the 7th or the 12th day after the sensitization an increase in the incidence of the disease occurred in the grooups. A fall of morbidity correlated with a reduction of percentage of positive skin tests in response to the intradermal injection of a homologous myelin. No reduction in the production of the complement-fixing, antibodies to the heterologous antigen was seen in the animals given ALS. This pointed to the participation of cell factors in the development of the pathological process. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/953349/[Influence_of_antilymphocyte_sera_on_the_development_of_experimental_allergic_encephalomyelitis]_ DB - PRIME DP - Unbound Medicine ER -