Tags

Type your tag names separated by a space and hit enter

[The effectiveness and tolerability of losartan and effect on left ventricular mass in patients with essential hypertension].
Cardiologia. 1998 Jan; 43(1):53-9.C

Abstract

The purpose of our study was to evaluate the antihypertensive efficacy, tolerability and effects on left ventricular mass of losartan over 10 months in patients with essential hypertension. Losartan is a selective angiotensin II receptor-antagonist. The whole study comprised 89 hypertensive patients who were randomized, at baseline, to 10 months of double-blind once daily treatment with losartan 50 mg (L Group, n = 49, mean age 55 +/- 13 years) or hydrochlorothiazide 25 mg (HCTZ Group, n = 40, mean age 56 +/- 10 years). Routine hematology, blood chemistry and urinalysis were performed before and after 5 and 10 months; standard electrocardiography, ambulatory non invasive 24-hours blood pressure monitoring, M-mode echocardiography, psychometric test and quality of life evaluation were obtained from all the patients before and after 10 months. In patients non responding after 4 weeks, hydrochlorothiazide 25 mg or losartan 50 mg was added in the L Group and in the HCTZ Group, respectively (L-HCTZ Group). The results showed good tolerability and a significant mean systolic and diastolic blood pressure reduction in all groups (L Group from 157/96 +/- 9/7 to 137/85 +/- 9/5 mmHg, p < 0.001; HCTZ Group from 158/97 +/- 11/8 to 150/91 +/- 9/7 mmHg, p < 0.003; L-HCTZ Group from 159/98 +/- 9/5 to 141/88 +/- 6/4 mmHg, p < 0.001), although L and L-HCTZ treatment were more effective during 24 hours than HCTZ. Moreover, a remarkable reduction in left ventricular mass index was obtained after 10 months only in the L Group (from 138.4 +/- 26.2 to 127.2 +/- 23.1 g/m2, p < 0.04) and in the L-HCTZ Group (from 140 +/- 20.3 to 125.5 +/- 20.1 g/m2, p = 0.126). Finally, in patients treated with losartan the results of psychometric test significantly improved (L Group: p < 0.05; L-HCTZ Group: p < 0.05) and a positive remarkable change in the quality of life was observed (L Group: p < 0.05; L-HCTZ Group: p = 0.083). In conclusion, losartan in monotherapy or in association with hydrochlorothiazide, was well tolerated, respected the quality of life, and produced a significant and remarkable reduction in blood pressure and left ventricular mass in hypertensive patients.

Authors+Show Affiliations

Cattedra di Cardiologia, Seconda Università degli Studi, Napoli.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

9534293

Citation

Tedesco, M A., et al. "[The Effectiveness and Tolerability of Losartan and Effect On Left Ventricular Mass in Patients With Essential Hypertension]." Cardiologia (Rome, Italy), vol. 43, no. 1, 1998, pp. 53-9.
Tedesco MA, Ratti G, Aquino D, et al. [The effectiveness and tolerability of losartan and effect on left ventricular mass in patients with essential hypertension]. Cardiologia. 1998;43(1):53-9.
Tedesco, M. A., Ratti, G., Aquino, D., Caccavale, A., Acitorio, M., Rocereto, A., Cosimi, R., Coppolino, P., Iarussi, D., & Iacono, A. (1998). [The effectiveness and tolerability of losartan and effect on left ventricular mass in patients with essential hypertension]. Cardiologia (Rome, Italy), 43(1), 53-9.
Tedesco MA, et al. [The Effectiveness and Tolerability of Losartan and Effect On Left Ventricular Mass in Patients With Essential Hypertension]. Cardiologia. 1998;43(1):53-9. PubMed PMID: 9534293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effectiveness and tolerability of losartan and effect on left ventricular mass in patients with essential hypertension]. AU - Tedesco,M A, AU - Ratti,G, AU - Aquino,D, AU - Caccavale,A, AU - Acitorio,M, AU - Rocereto,A, AU - Cosimi,R, AU - Coppolino,P, AU - Iarussi,D, AU - Iacono,A, PY - 1998/4/16/pubmed PY - 1998/4/16/medline PY - 1998/4/16/entrez SP - 53 EP - 9 JF - Cardiologia (Rome, Italy) JO - Cardiologia VL - 43 IS - 1 N2 - The purpose of our study was to evaluate the antihypertensive efficacy, tolerability and effects on left ventricular mass of losartan over 10 months in patients with essential hypertension. Losartan is a selective angiotensin II receptor-antagonist. The whole study comprised 89 hypertensive patients who were randomized, at baseline, to 10 months of double-blind once daily treatment with losartan 50 mg (L Group, n = 49, mean age 55 +/- 13 years) or hydrochlorothiazide 25 mg (HCTZ Group, n = 40, mean age 56 +/- 10 years). Routine hematology, blood chemistry and urinalysis were performed before and after 5 and 10 months; standard electrocardiography, ambulatory non invasive 24-hours blood pressure monitoring, M-mode echocardiography, psychometric test and quality of life evaluation were obtained from all the patients before and after 10 months. In patients non responding after 4 weeks, hydrochlorothiazide 25 mg or losartan 50 mg was added in the L Group and in the HCTZ Group, respectively (L-HCTZ Group). The results showed good tolerability and a significant mean systolic and diastolic blood pressure reduction in all groups (L Group from 157/96 +/- 9/7 to 137/85 +/- 9/5 mmHg, p < 0.001; HCTZ Group from 158/97 +/- 11/8 to 150/91 +/- 9/7 mmHg, p < 0.003; L-HCTZ Group from 159/98 +/- 9/5 to 141/88 +/- 6/4 mmHg, p < 0.001), although L and L-HCTZ treatment were more effective during 24 hours than HCTZ. Moreover, a remarkable reduction in left ventricular mass index was obtained after 10 months only in the L Group (from 138.4 +/- 26.2 to 127.2 +/- 23.1 g/m2, p < 0.04) and in the L-HCTZ Group (from 140 +/- 20.3 to 125.5 +/- 20.1 g/m2, p = 0.126). Finally, in patients treated with losartan the results of psychometric test significantly improved (L Group: p < 0.05; L-HCTZ Group: p < 0.05) and a positive remarkable change in the quality of life was observed (L Group: p < 0.05; L-HCTZ Group: p = 0.083). In conclusion, losartan in monotherapy or in association with hydrochlorothiazide, was well tolerated, respected the quality of life, and produced a significant and remarkable reduction in blood pressure and left ventricular mass in hypertensive patients. SN - 0393-1978 UR - https://www.unboundmedicine.com/medline/citation/9534293/[The_effectiveness_and_tolerability_of_losartan_and_effect_on_left_ventricular_mass_in_patients_with_essential_hypertension]_ L2 - http://www.diseaseinfosearch.org/result/8360 DB - PRIME DP - Unbound Medicine ER -