Tags

Type your tag names separated by a space and hit enter

Comparison of short- and long-term effects of different dietary fats on the hepatic uptake and metabolism of chylomicron remnants in rats.
Br J Nutr. 1998 Feb; 79(2):203-11.BJ

Abstract

The uptake and metabolism of [14C]oleate-labelled chylomicron remnants derived from olive oil, maize oil, palm oil, fish oil or butter fat was investigated using perfused livers from rats fed on the corresponding fat-supplemented diet (providing 40% of the dietary energy) or a low-fat diet for 21 d. The percentage of added [14C]oleate-labelled remnant removed from the perfusate was similar for livers from rats fed on the fat-supplemented diets irrespective of the type of fat fed, whereas livers from rats fed on the low-fat diet removed more labelled fish oil and butter fat remnants than olive, maize or palm oil remnants. Following hepatic uptake in the fat-supplemented groups, the oxidation of [14C]oleate-labelled remnant lipid from maize oil, fish oil, and butter fat remnants was greater than that of the lipids from olive and palm oil remnants, although only the oxidation of lipids from maize and palm oil remnants was increased by prior fat-supplementation of the diet. In addition, the livers from rats fed on the fish-oil-supplemented diet incorporated more [14C]oleate-labelled remnant lipid into phospholipid compared with the livers from rats fed on the other fat-supplemented diets or the low-fat diets. These investigations show that both prior fat feeding and the composition of the fat fed, as well as the fatty acid composition of the chylomicron remnant particles themselves, influence the uptake and metabolism of chylomicron remnants by the liver.

Authors+Show Affiliations

Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9536865

Citation

Lambert, M S., et al. "Comparison of Short- and Long-term Effects of Different Dietary Fats On the Hepatic Uptake and Metabolism of Chylomicron Remnants in Rats." The British Journal of Nutrition, vol. 79, no. 2, 1998, pp. 203-11.
Lambert MS, Avella MA, Botham KM, et al. Comparison of short- and long-term effects of different dietary fats on the hepatic uptake and metabolism of chylomicron remnants in rats. Br J Nutr. 1998;79(2):203-11.
Lambert, M. S., Avella, M. A., Botham, K. M., & Mayes, P. A. (1998). Comparison of short- and long-term effects of different dietary fats on the hepatic uptake and metabolism of chylomicron remnants in rats. The British Journal of Nutrition, 79(2), 203-11.
Lambert MS, et al. Comparison of Short- and Long-term Effects of Different Dietary Fats On the Hepatic Uptake and Metabolism of Chylomicron Remnants in Rats. Br J Nutr. 1998;79(2):203-11. PubMed PMID: 9536865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of short- and long-term effects of different dietary fats on the hepatic uptake and metabolism of chylomicron remnants in rats. AU - Lambert,M S, AU - Avella,M A, AU - Botham,K M, AU - Mayes,P A, PY - 1998/4/16/pubmed PY - 1998/4/16/medline PY - 1998/4/16/entrez SP - 203 EP - 11 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 79 IS - 2 N2 - The uptake and metabolism of [14C]oleate-labelled chylomicron remnants derived from olive oil, maize oil, palm oil, fish oil or butter fat was investigated using perfused livers from rats fed on the corresponding fat-supplemented diet (providing 40% of the dietary energy) or a low-fat diet for 21 d. The percentage of added [14C]oleate-labelled remnant removed from the perfusate was similar for livers from rats fed on the fat-supplemented diets irrespective of the type of fat fed, whereas livers from rats fed on the low-fat diet removed more labelled fish oil and butter fat remnants than olive, maize or palm oil remnants. Following hepatic uptake in the fat-supplemented groups, the oxidation of [14C]oleate-labelled remnant lipid from maize oil, fish oil, and butter fat remnants was greater than that of the lipids from olive and palm oil remnants, although only the oxidation of lipids from maize and palm oil remnants was increased by prior fat-supplementation of the diet. In addition, the livers from rats fed on the fish-oil-supplemented diet incorporated more [14C]oleate-labelled remnant lipid into phospholipid compared with the livers from rats fed on the other fat-supplemented diets or the low-fat diets. These investigations show that both prior fat feeding and the composition of the fat fed, as well as the fatty acid composition of the chylomicron remnant particles themselves, influence the uptake and metabolism of chylomicron remnants by the liver. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9536865/Comparison_of_short__and_long_term_effects_of_different_dietary_fats_on_the_hepatic_uptake_and_metabolism_of_chylomicron_remnants_in_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114598000336/type/journal_article DB - PRIME DP - Unbound Medicine ER -