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Triiodothyronine and thyroxine interrelationships in health and disease.
Can Med Assoc J. 1976 Aug 21; 115(4):338-42.CM

Abstract

With the recent development of radioimmunoassay techniques for the measurement of serum triiodothyronine (T3) concentration, new concepts have arisen regarding the biologic role of T3 in health and disease and its interrelationships with thyroxine (T4). An awareness of the influence of clinical conditions that affect binding of thyroid hormone to plasma proteins is required in the interpretation of moderately increased or decreased serum T3 values. Hormone preparations containing T3 may produce transient increases in T3 concentration into the hyperthyroid range. Measurements of serum T3 concentration appear to be particularly indicated in clinical situations in which hyperthyroidism is suspected but serum T3 resin uptake and serum T4 values are normal, to exclude the T3-toxicosis syndrome. Also, when serum T4 values are in the hypothyroid range, measurement of serum T3 as well as serum thyrotropin (TSH) concentrations can lead to recognition of abnormalities in thyroid gland biosynthesis. Before a diagnosis of hypothyroidism is made on the basis of a low serum T3 value, one must exclude a variety of clinical nonthyroidal conditions that can result in changes in plasma T3 protein binding or impaired peripheral conversion of T4 to metabolically active T3 without producing a hypometabolic state.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

953904

Citation

Walfish, P G.. "Triiodothyronine and Thyroxine Interrelationships in Health and Disease." Canadian Medical Association Journal, vol. 115, no. 4, 1976, pp. 338-42.
Walfish PG. Triiodothyronine and thyroxine interrelationships in health and disease. Can Med Assoc J. 1976;115(4):338-42.
Walfish, P. G. (1976). Triiodothyronine and thyroxine interrelationships in health and disease. Canadian Medical Association Journal, 115(4), 338-42.
Walfish PG. Triiodothyronine and Thyroxine Interrelationships in Health and Disease. Can Med Assoc J. 1976 Aug 21;115(4):338-42. PubMed PMID: 953904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triiodothyronine and thyroxine interrelationships in health and disease. A1 - Walfish,P G, PY - 1976/8/21/pubmed PY - 1976/8/21/medline PY - 1976/8/21/entrez SP - 338 EP - 42 JF - Canadian Medical Association journal JO - Can Med Assoc J VL - 115 IS - 4 N2 - With the recent development of radioimmunoassay techniques for the measurement of serum triiodothyronine (T3) concentration, new concepts have arisen regarding the biologic role of T3 in health and disease and its interrelationships with thyroxine (T4). An awareness of the influence of clinical conditions that affect binding of thyroid hormone to plasma proteins is required in the interpretation of moderately increased or decreased serum T3 values. Hormone preparations containing T3 may produce transient increases in T3 concentration into the hyperthyroid range. Measurements of serum T3 concentration appear to be particularly indicated in clinical situations in which hyperthyroidism is suspected but serum T3 resin uptake and serum T4 values are normal, to exclude the T3-toxicosis syndrome. Also, when serum T4 values are in the hypothyroid range, measurement of serum T3 as well as serum thyrotropin (TSH) concentrations can lead to recognition of abnormalities in thyroid gland biosynthesis. Before a diagnosis of hypothyroidism is made on the basis of a low serum T3 value, one must exclude a variety of clinical nonthyroidal conditions that can result in changes in plasma T3 protein binding or impaired peripheral conversion of T4 to metabolically active T3 without producing a hypometabolic state. SN - 0008-4409 UR - https://www.unboundmedicine.com/medline/citation/953904/Triiodothyronine_and_thyroxine_interrelationships_in_health_and_disease_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/953904/ DB - PRIME DP - Unbound Medicine ER -