Abstract
AIM
To compare the effectiveness of griseofulvin and terbinafine in the treatment of tinea capitis in children.
METHOD
Twenty four consecutive patients with culture proven tinea capitis were treated randomly with griseofulvin (10 mg/kg/day for 8 weeks) or terbinafine (62.5-250 mg/day for 4 weeks). Outcome was determined by absence of clinical signs, hair regrowth or negative mycology.
RESULTS
Twenty four patients (16 male, 8 female) were treated. Age ranged between 2 and 15 years (mean 4.8). Seven patients presented with kerion, the remainder with a scaling and patchy alopecia pattern of tinea capitis. The responsible organisms were Microsporum canis (17 cases) and Trichophyton verrucosum (7 cases). Fourteen children were treated with griseofulvin and 10 with terbinafine. By three months follow up, 19 patients had cleared completely with good new hair regrowth. Three children had no active disease but only minimal new hair growth. One child (griseofulvin group) had no hair regrowth but was culture negative. She had sustained significant dermal and subcutaneous skin damage requiring plastic surgery. The other (terbinafine group) had ongoing active kerion.
CONCLUSION
Both griseofulvin and terbinafine are equally effective in the treatment of tinea capitis.
TY - JOUR
T1 - Griseofulvin and terbinafine in the treatment of tinea capitis in children.
AU - Rademaker,M,
AU - Havill,S,
PY - 1998/4/16/pubmed
PY - 1998/4/16/medline
PY - 1998/4/16/entrez
SP - 55
EP - 7
JF - The New Zealand medical journal
JO - N Z Med J
VL - 111
IS - 1060
N2 - AIM: To compare the effectiveness of griseofulvin and terbinafine in the treatment of tinea capitis in children. METHOD: Twenty four consecutive patients with culture proven tinea capitis were treated randomly with griseofulvin (10 mg/kg/day for 8 weeks) or terbinafine (62.5-250 mg/day for 4 weeks). Outcome was determined by absence of clinical signs, hair regrowth or negative mycology. RESULTS: Twenty four patients (16 male, 8 female) were treated. Age ranged between 2 and 15 years (mean 4.8). Seven patients presented with kerion, the remainder with a scaling and patchy alopecia pattern of tinea capitis. The responsible organisms were Microsporum canis (17 cases) and Trichophyton verrucosum (7 cases). Fourteen children were treated with griseofulvin and 10 with terbinafine. By three months follow up, 19 patients had cleared completely with good new hair regrowth. Three children had no active disease but only minimal new hair growth. One child (griseofulvin group) had no hair regrowth but was culture negative. She had sustained significant dermal and subcutaneous skin damage requiring plastic surgery. The other (terbinafine group) had ongoing active kerion. CONCLUSION: Both griseofulvin and terbinafine are equally effective in the treatment of tinea capitis.
SN - 0028-8446
UR - https://www.unboundmedicine.com/medline/citation/9539918/Griseofulvin_and_terbinafine_in_the_treatment_of_tinea_capitis_in_children_
L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:9539918
DB - PRIME
DP - Unbound Medicine
ER -