Tags

Type your tag names separated by a space and hit enter

Griseofulvin and terbinafine in the treatment of tinea capitis in children.
N Z Med J. 1998 Feb 27; 111(1060):55-7.NZ

Abstract

AIM

To compare the effectiveness of griseofulvin and terbinafine in the treatment of tinea capitis in children.

METHOD

Twenty four consecutive patients with culture proven tinea capitis were treated randomly with griseofulvin (10 mg/kg/day for 8 weeks) or terbinafine (62.5-250 mg/day for 4 weeks). Outcome was determined by absence of clinical signs, hair regrowth or negative mycology.

RESULTS

Twenty four patients (16 male, 8 female) were treated. Age ranged between 2 and 15 years (mean 4.8). Seven patients presented with kerion, the remainder with a scaling and patchy alopecia pattern of tinea capitis. The responsible organisms were Microsporum canis (17 cases) and Trichophyton verrucosum (7 cases). Fourteen children were treated with griseofulvin and 10 with terbinafine. By three months follow up, 19 patients had cleared completely with good new hair regrowth. Three children had no active disease but only minimal new hair growth. One child (griseofulvin group) had no hair regrowth but was culture negative. She had sustained significant dermal and subcutaneous skin damage requiring plastic surgery. The other (terbinafine group) had ongoing active kerion.

CONCLUSION

Both griseofulvin and terbinafine are equally effective in the treatment of tinea capitis.

Links

patent databases

Authors+Show Affiliations

Rademaker M
Department of Dermatology, Health Waikato, Hamilton.
Havill S
No affiliation info available

MeSH

AdolescentAntifungal AgentsChildChild, PreschoolDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesGriseofulvinHumansMaleMicrosporumNaphthalenesProspective StudiesTerbinafineTinea CapitisTreatment OutcomeTrichophyton

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9539918

Citation

Rademaker, M, and S Havill. "Griseofulvin and Terbinafine in the Treatment of Tinea Capitis in Children." The New Zealand Medical Journal, vol. 111, no. 1060, 1998, pp. 55-7.
Rademaker M, Havill S. Griseofulvin and terbinafine in the treatment of tinea capitis in children. N Z Med J. 1998;111(1060):55-7.
Rademaker, M., & Havill, S. (1998). Griseofulvin and terbinafine in the treatment of tinea capitis in children. The New Zealand Medical Journal, 111(1060), 55-7.
Rademaker M, Havill S. Griseofulvin and Terbinafine in the Treatment of Tinea Capitis in Children. N Z Med J. 1998 Feb 27;111(1060):55-7. PubMed PMID: 9539918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Griseofulvin and terbinafine in the treatment of tinea capitis in children. AU - Rademaker,M, AU - Havill,S, PY - 1998/4/16/pubmed PY - 1998/4/16/medline PY - 1998/4/16/entrez SP - 55 EP - 7 JF - The New Zealand medical journal JO - N Z Med J VL - 111 IS - 1060 N2 - AIM: To compare the effectiveness of griseofulvin and terbinafine in the treatment of tinea capitis in children. METHOD: Twenty four consecutive patients with culture proven tinea capitis were treated randomly with griseofulvin (10 mg/kg/day for 8 weeks) or terbinafine (62.5-250 mg/day for 4 weeks). Outcome was determined by absence of clinical signs, hair regrowth or negative mycology. RESULTS: Twenty four patients (16 male, 8 female) were treated. Age ranged between 2 and 15 years (mean 4.8). Seven patients presented with kerion, the remainder with a scaling and patchy alopecia pattern of tinea capitis. The responsible organisms were Microsporum canis (17 cases) and Trichophyton verrucosum (7 cases). Fourteen children were treated with griseofulvin and 10 with terbinafine. By three months follow up, 19 patients had cleared completely with good new hair regrowth. Three children had no active disease but only minimal new hair growth. One child (griseofulvin group) had no hair regrowth but was culture negative. She had sustained significant dermal and subcutaneous skin damage requiring plastic surgery. The other (terbinafine group) had ongoing active kerion. CONCLUSION: Both griseofulvin and terbinafine are equally effective in the treatment of tinea capitis. SN - 0028-8446 UR - https://www.unboundmedicine.com/medline/citation/9539918/Griseofulvin_and_terbinafine_in_the_treatment_of_tinea_capitis_in_children_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:9539918 DB - PRIME DP - Unbound Medicine ER -