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Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III.
Am J Psychiatry. 1998 Apr; 155(4):565-7.AJ

Abstract

OBJECTIVE

The authors examined the association between three lifetime medication variables (cumulative amount of neuroleptics, number of interruptions in neuroleptic treatment, cumulative amount of anticholinergics) and the occurrence and severity of tardive dyskinesia.

METHOD

The study was conducted in the only psychiatric hospital of a well-defined catchment area (the Netherlands Antilles). For all patients who had a history of taking neuroleptics for at least 3 months and were currently using neuroleptics (N = 133, mean age = 51.5 years), the presence and severity of tardive dyskinesia were measured with the Abnormal Involuntary Movement Scale.

RESULTS

Of the three lifetime medication variables, only the number of neuroleptic interruptions was significantly related to tardive dyskinesia. The risk of tardive dyskinesia was three times as great for patients with more than two neuroleptic interruptions as for patients with two or fewer interruptions.

CONCLUSIONS

This finding supports the schizophrenia protocol of long-term neuroleptic treatment rather than targeted or intermittent neuroleptic treatment.

Authors+Show Affiliations

Dr. David Ricardo Capriles Clinic, Curaçao, Netherlands Antilles. hartenp@knmg.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9546009

Citation

van Harten, P N., et al. "Intermittent Neuroleptic Treatment and Risk for Tardive Dyskinesia: Curaçao Extrapyramidal Syndromes Study III." The American Journal of Psychiatry, vol. 155, no. 4, 1998, pp. 565-7.
van Harten PN, Hoek HW, Matroos GE, et al. Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III. Am J Psychiatry. 1998;155(4):565-7.
van Harten, P. N., Hoek, H. W., Matroos, G. E., Koeter, M., & Kahn, R. S. (1998). Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III. The American Journal of Psychiatry, 155(4), 565-7.
van Harten PN, et al. Intermittent Neuroleptic Treatment and Risk for Tardive Dyskinesia: Curaçao Extrapyramidal Syndromes Study III. Am J Psychiatry. 1998;155(4):565-7. PubMed PMID: 9546009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III. AU - van Harten,P N, AU - Hoek,H W, AU - Matroos,G E, AU - Koeter,M, AU - Kahn,R S, PY - 1998/4/18/pubmed PY - 1998/4/18/medline PY - 1998/4/18/entrez SP - 565 EP - 7 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 155 IS - 4 N2 - OBJECTIVE: The authors examined the association between three lifetime medication variables (cumulative amount of neuroleptics, number of interruptions in neuroleptic treatment, cumulative amount of anticholinergics) and the occurrence and severity of tardive dyskinesia. METHOD: The study was conducted in the only psychiatric hospital of a well-defined catchment area (the Netherlands Antilles). For all patients who had a history of taking neuroleptics for at least 3 months and were currently using neuroleptics (N = 133, mean age = 51.5 years), the presence and severity of tardive dyskinesia were measured with the Abnormal Involuntary Movement Scale. RESULTS: Of the three lifetime medication variables, only the number of neuroleptic interruptions was significantly related to tardive dyskinesia. The risk of tardive dyskinesia was three times as great for patients with more than two neuroleptic interruptions as for patients with two or fewer interruptions. CONCLUSIONS: This finding supports the schizophrenia protocol of long-term neuroleptic treatment rather than targeted or intermittent neuroleptic treatment. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/9546009/Intermittent_neuroleptic_treatment_and_risk_for_tardive_dyskinesia:_Curaçao_Extrapyramidal_Syndromes_Study_III_ L2 - https://ajp.psychiatryonline.org/doi/10.1176/ajp.155.4.565?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -