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Folate supplementation and neural tube defects: a review of a public health issue.
P R Health Sci J. 1997 Dec; 16(4):387-93.PR

Abstract

Folate deficiency is one of today's most common vitamin deficiencies in women. Women who consume a low level of folate during pregnancy are at risk for poor pregnancy outcomes including neural tube defects (NTD). However, other factors such as heredity, social class, maternal age, birth order, maternal diet, length of time between pregnancies, maternal zinc deficiency, use of anticonvulsant drugs, abnormal homocysteine metabolism and the use of oral contraceptives, have also been implicated as causes of NTD. Animal studies have shown that fetuses are highly dependent on the folate status of the mother. In addition, several retrospective and prospective human studies have provided evidence that folate lowers the incidence of NTD.

Authors+Show Affiliations

University of Puerto Rico, School of Public Health, Nutrition Program, San Juan 00936-5067.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9547830

Citation

González, M J., et al. "Folate Supplementation and Neural Tube Defects: a Review of a Public Health Issue." Puerto Rico Health Sciences Journal, vol. 16, no. 4, 1997, pp. 387-93.
González MJ, Schmitz KJ, Matos MI, et al. Folate supplementation and neural tube defects: a review of a public health issue. P R Health Sci J. 1997;16(4):387-93.
González, M. J., Schmitz, K. J., Matos, M. I., López, D., Rodríguez, J. R., & Gorrín, J. J. (1997). Folate supplementation and neural tube defects: a review of a public health issue. Puerto Rico Health Sciences Journal, 16(4), 387-93.
González MJ, et al. Folate Supplementation and Neural Tube Defects: a Review of a Public Health Issue. P R Health Sci J. 1997;16(4):387-93. PubMed PMID: 9547830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate supplementation and neural tube defects: a review of a public health issue. AU - González,M J, AU - Schmitz,K J, AU - Matos,M I, AU - López,D, AU - Rodríguez,J R, AU - Gorrín,J J, PY - 1998/4/21/pubmed PY - 1998/4/21/medline PY - 1998/4/21/entrez SP - 387 EP - 93 JF - Puerto Rico health sciences journal JO - P R Health Sci J VL - 16 IS - 4 N2 - Folate deficiency is one of today's most common vitamin deficiencies in women. Women who consume a low level of folate during pregnancy are at risk for poor pregnancy outcomes including neural tube defects (NTD). However, other factors such as heredity, social class, maternal age, birth order, maternal diet, length of time between pregnancies, maternal zinc deficiency, use of anticonvulsant drugs, abnormal homocysteine metabolism and the use of oral contraceptives, have also been implicated as causes of NTD. Animal studies have shown that fetuses are highly dependent on the folate status of the mother. In addition, several retrospective and prospective human studies have provided evidence that folate lowers the incidence of NTD. SN - 0738-0658 UR - https://www.unboundmedicine.com/medline/citation/9547830/Folate_supplementation_and_neural_tube_defects:_a_review_of_a_public_health_issue_ L2 - http://www.diseaseinfosearch.org/result/8992 DB - PRIME DP - Unbound Medicine ER -