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Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy.
Biol Psychiatry. 1998 Apr 01; 43(7):483-8.BP

Abstract

BACKGROUND

Previous neuropathological and neuroimaging studies have documented neuronal loss in the hippocampal region in schizophrenia. N-acetylaspartate (NAA) is a neuronal/axonal marker that may be utilized to assess neuronal loss or dysfunction by proton magnetic resonance spectroscopy (1H MRS). This study measured NAA, choline, and creatine in the hippocampal region of patients with schizophrenia using in vivo proton magnetic resonance spectroscopic imaging (1H MRSI).

METHODS

1H MRSI was performed on the right and left hippocampal regions in 30 chronic schizophrenic patients and 18 control subjects. Concentration estimates of NAA, creatine, and choline were determined.

RESULTS

Relative to the control group, the patients with schizophrenia demonstrated significantly lower NAA in both the right and left hippocampal regions. No group differences in choline were noted; however, there was a trend for creatine to be higher on the left than the right hippocampus in the schizophrenic group. There was also no association between NAA and duration of illness or medication dosage.

CONCLUSIONS

This preliminary study provides support for neuronal dysfunction and/or decreased neuronal density in the hippocampal region. The absence of choline signal elevation does not support accelerated turnover of membrane phospholipids, which might be expected if there were ongoing neuronal atrophy or neuronal necrosis.

Authors+Show Affiliations

Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9547926

Citation

Deicken, R F., et al. "Hippocampal Neuronal Dysfunction in Schizophrenia as Measured By Proton Magnetic Resonance Spectroscopy." Biological Psychiatry, vol. 43, no. 7, 1998, pp. 483-8.
Deicken RF, Zhou L, Schuff N, et al. Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biol Psychiatry. 1998;43(7):483-8.
Deicken, R. F., Zhou, L., Schuff, N., Fein, G., & Weiner, M. W. (1998). Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biological Psychiatry, 43(7), 483-8.
Deicken RF, et al. Hippocampal Neuronal Dysfunction in Schizophrenia as Measured By Proton Magnetic Resonance Spectroscopy. Biol Psychiatry. 1998 Apr 1;43(7):483-8. PubMed PMID: 9547926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. AU - Deicken,R F, AU - Zhou,L, AU - Schuff,N, AU - Fein,G, AU - Weiner,M W, PY - 1998/4/21/pubmed PY - 1998/4/21/medline PY - 1998/4/21/entrez SP - 483 EP - 8 JF - Biological psychiatry JO - Biol. Psychiatry VL - 43 IS - 7 N2 - BACKGROUND: Previous neuropathological and neuroimaging studies have documented neuronal loss in the hippocampal region in schizophrenia. N-acetylaspartate (NAA) is a neuronal/axonal marker that may be utilized to assess neuronal loss or dysfunction by proton magnetic resonance spectroscopy (1H MRS). This study measured NAA, choline, and creatine in the hippocampal region of patients with schizophrenia using in vivo proton magnetic resonance spectroscopic imaging (1H MRSI). METHODS: 1H MRSI was performed on the right and left hippocampal regions in 30 chronic schizophrenic patients and 18 control subjects. Concentration estimates of NAA, creatine, and choline were determined. RESULTS: Relative to the control group, the patients with schizophrenia demonstrated significantly lower NAA in both the right and left hippocampal regions. No group differences in choline were noted; however, there was a trend for creatine to be higher on the left than the right hippocampus in the schizophrenic group. There was also no association between NAA and duration of illness or medication dosage. CONCLUSIONS: This preliminary study provides support for neuronal dysfunction and/or decreased neuronal density in the hippocampal region. The absence of choline signal elevation does not support accelerated turnover of membrane phospholipids, which might be expected if there were ongoing neuronal atrophy or neuronal necrosis. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/9547926/Hippocampal_neuronal_dysfunction_in_schizophrenia_as_measured_by_proton_magnetic_resonance_spectroscopy_ DB - PRIME DP - Unbound Medicine ER -