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CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.
J Immunol. 1997 Dec 15; 159(12):6009-17.JI

Abstract

Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities.

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Authors+Show Affiliations

Poccia F
Department of Biology, University of Rome Tor Vergata, Italy. poccia@utovrm.it
Cipriani B
No affiliation info available
Vendetti S
No affiliation info available
Colizzi V
No affiliation info available
Poquet Y
No affiliation info available
Battistini L
No affiliation info available
López-Botet M
No affiliation info available
Fournié JJ
No affiliation info available
Gougeon ML
No affiliation info available

MeSH

Antigens, BacterialAntigens, CDAntigens, ViralCytotoxicity Tests, ImmunologicGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHIV-1Histocompatibility Antigens Class IHumansKiller Cells, NaturalLectins, C-TypeLymphocyte ActivationMembrane GlycoproteinsMycobacterium fortuitumNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, MitogenReceptors, Natural Killer CellT-Lymphocyte SubsetsT-Lymphocytes, CytotoxicTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9550399

Citation

Poccia, F, et al. "CD94/NKG2 Inhibitory Receptor Complex Modulates Both Anti-viral and Anti-tumoral Responses of Polyclonal Phosphoantigen-reactive V Gamma 9V Delta 2 T Lymphocytes." Journal of Immunology (Baltimore, Md. : 1950), vol. 159, no. 12, 1997, pp. 6009-17.
Poccia F, Cipriani B, Vendetti S, et al. CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. J Immunol. 1997;159(12):6009-17.
Poccia, F., Cipriani, B., Vendetti, S., Colizzi, V., Poquet, Y., Battistini, L., López-Botet, M., Fournié, J. J., & Gougeon, M. L. (1997). CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950), 159(12), 6009-17.
Poccia F, et al. CD94/NKG2 Inhibitory Receptor Complex Modulates Both Anti-viral and Anti-tumoral Responses of Polyclonal Phosphoantigen-reactive V Gamma 9V Delta 2 T Lymphocytes. J Immunol. 1997 Dec 15;159(12):6009-17. PubMed PMID: 9550399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. AU - Poccia,F, AU - Cipriani,B, AU - Vendetti,S, AU - Colizzi,V, AU - Poquet,Y, AU - Battistini,L, AU - López-Botet,M, AU - Fournié,J J, AU - Gougeon,M L, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 6009 EP - 17 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 159 IS - 12 N2 - Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/9550399/CD94/NKG2_inhibitory_receptor_complex_modulates_both_anti_viral_and_anti_tumoral_responses_of_polyclonal_phosphoantigen_reactive_V_gamma_9V_delta_2_T_lymphocytes_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=9550399 DB - PRIME DP - Unbound Medicine ER -