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CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.
J Immunol. 1997 Dec 15; 159(12):6009-17.JI

Abstract

Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities.

Authors+Show Affiliations

Department of Biology, University of Rome Tor Vergata, Italy. poccia@utovrm.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9550399

Citation

Poccia, F, et al. "CD94/NKG2 Inhibitory Receptor Complex Modulates Both Anti-viral and Anti-tumoral Responses of Polyclonal Phosphoantigen-reactive V Gamma 9V Delta 2 T Lymphocytes." Journal of Immunology (Baltimore, Md. : 1950), vol. 159, no. 12, 1997, pp. 6009-17.
Poccia F, Cipriani B, Vendetti S, et al. CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. J Immunol. 1997;159(12):6009-17.
Poccia, F., Cipriani, B., Vendetti, S., Colizzi, V., Poquet, Y., Battistini, L., López-Botet, M., Fournié, J. J., & Gougeon, M. L. (1997). CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950), 159(12), 6009-17.
Poccia F, et al. CD94/NKG2 Inhibitory Receptor Complex Modulates Both Anti-viral and Anti-tumoral Responses of Polyclonal Phosphoantigen-reactive V Gamma 9V Delta 2 T Lymphocytes. J Immunol. 1997 Dec 15;159(12):6009-17. PubMed PMID: 9550399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. AU - Poccia,F, AU - Cipriani,B, AU - Vendetti,S, AU - Colizzi,V, AU - Poquet,Y, AU - Battistini,L, AU - López-Botet,M, AU - Fournié,J J, AU - Gougeon,M L, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 6009 EP - 17 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 159 IS - 12 N2 - Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/9550399/CD94/NKG2_inhibitory_receptor_complex_modulates_both_anti_viral_and_anti_tumoral_responses_of_polyclonal_phosphoantigen_reactive_V_gamma_9V_delta_2_T_lymphocytes_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=9550399 DB - PRIME DP - Unbound Medicine ER -