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Intoxication by star fruit (Averrhoa carambola) in six dialysis patients? (Preliminary report)
Nephrol Dial Transplant. 1998 Mar; 13(3):570-2.ND

Abstract

We observed six cases of patients in a dialysis programme who were apparently intoxicated by ingestion of star fruit. After ingestion of 2-3 fruits or 150-200 ml of the fruit juice, the six patients, who had previously been stable in a regular dialysis programme, developed a variety of symptoms ranging from insomnia and hiccups to agitation, mental confusion and (in one case) death. In preliminary investigations to characterize the hypothetical neurotoxin in the fruit, an extract, when injected intraperitoneally or intracerebroventricularly in rats, provoked persistent convulsions of the tonic-clonic type. It appears that star fruit (Averrhoa carambola) contains an excitatory neurotoxin. Patients with renal failure on conservative or dialysis treatment should be dissuaded from ingestion of the fruit.

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Publisher Full Text

Authors

Neto MM
No affiliation info available
Robl F
No affiliation info available
Netto JC
No affiliation info available

MeSH

AgedAnimalsBrazilConfusionDiabetic NephropathiesFemaleFruitHiccupHumansMaleMiddle AgedNeurotoxinsPeritoneal Dialysis, Continuous AmbulatoryPlant ExtractsRatsRenal DialysisSeizuresSleep Wake Disorders

Pub Type(s)

News

Language

eng

PubMed ID

9550629

Citation

Neto, M M., et al. "Intoxication By Star Fruit (Averrhoa Carambola) in Six Dialysis Patients? (Preliminary Report)." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 13, no. 3, 1998, pp. 570-2.
Neto MM, Robl F, Netto JC. Intoxication by star fruit (Averrhoa carambola) in six dialysis patients? (Preliminary report). Nephrol Dial Transplant. 1998;13(3):570-2.
Neto, M. M., Robl, F., & Netto, J. C. (1998). Intoxication by star fruit (Averrhoa carambola) in six dialysis patients? (Preliminary report). Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 13(3), 570-2.
Neto MM, Robl F, Netto JC. Intoxication By Star Fruit (Averrhoa Carambola) in Six Dialysis Patients? (Preliminary Report). Nephrol Dial Transplant. 1998;13(3):570-2. PubMed PMID: 9550629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intoxication by star fruit (Averrhoa carambola) in six dialysis patients? (Preliminary report) AU - Neto,M M, AU - Robl,F, AU - Netto,J C, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 570 EP - 2 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 13 IS - 3 N2 - We observed six cases of patients in a dialysis programme who were apparently intoxicated by ingestion of star fruit. After ingestion of 2-3 fruits or 150-200 ml of the fruit juice, the six patients, who had previously been stable in a regular dialysis programme, developed a variety of symptoms ranging from insomnia and hiccups to agitation, mental confusion and (in one case) death. In preliminary investigations to characterize the hypothetical neurotoxin in the fruit, an extract, when injected intraperitoneally or intracerebroventricularly in rats, provoked persistent convulsions of the tonic-clonic type. It appears that star fruit (Averrhoa carambola) contains an excitatory neurotoxin. Patients with renal failure on conservative or dialysis treatment should be dissuaded from ingestion of the fruit. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/9550629/Intoxication_by_star_fruit__Averrhoa_carambola__in_six_dialysis_patients__Preliminary_report_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/13.3.570 DB - PRIME DP - Unbound Medicine ER -