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Mechanisms and treatment options for bone loss in anorexia nervosa.
Psychopharmacol Bull 1997; 33(3):399-404PB

Abstract

Osteoporosis is present in over half of all patients with anorexia nervosa. Bone loss often occurs at a young age and may persist even after recovery, predisposing patients to debilitating spinal crush fractures. The pathogenesis of bone loss in anorexia nervosa is not completely understood and may result from a number of mechanisms, including estrogen deficiency, inadequate vitamin and calcium intake, and nutritional effects on bone formation. Recent studies demonstrate that estrogen itself is inadequate to increase bone density in a majority of patients with anorexia nervosa and suggest that nutritionally dependent factors such as insulin-like growth factor-I (IGF-I), a potent bone trophic hormone, may be important in maintaining bone mass. IT is hoped that new anabolic strategies to increase osteoblast function will become available in the future. In the interim, weight gain, restoration of gonadal function, and calcium supplementation remain the cornerstones of treatment in this disease.

Authors+Show Affiliations

Neuroendocrine Unit, Massachusetts General Hospital, Boston 02114, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9550884

Citation

Grinspoon, S, et al. "Mechanisms and Treatment Options for Bone Loss in Anorexia Nervosa." Psychopharmacology Bulletin, vol. 33, no. 3, 1997, pp. 399-404.
Grinspoon S, Herzog D, Klibanski A. Mechanisms and treatment options for bone loss in anorexia nervosa. Psychopharmacol Bull. 1997;33(3):399-404.
Grinspoon, S., Herzog, D., & Klibanski, A. (1997). Mechanisms and treatment options for bone loss in anorexia nervosa. Psychopharmacology Bulletin, 33(3), pp. 399-404.
Grinspoon S, Herzog D, Klibanski A. Mechanisms and Treatment Options for Bone Loss in Anorexia Nervosa. Psychopharmacol Bull. 1997;33(3):399-404. PubMed PMID: 9550884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms and treatment options for bone loss in anorexia nervosa. AU - Grinspoon,S, AU - Herzog,D, AU - Klibanski,A, PY - 1997/1/1/pubmed PY - 1998/4/29/medline PY - 1997/1/1/entrez SP - 399 EP - 404 JF - Psychopharmacology bulletin JO - Psychopharmacol Bull VL - 33 IS - 3 N2 - Osteoporosis is present in over half of all patients with anorexia nervosa. Bone loss often occurs at a young age and may persist even after recovery, predisposing patients to debilitating spinal crush fractures. The pathogenesis of bone loss in anorexia nervosa is not completely understood and may result from a number of mechanisms, including estrogen deficiency, inadequate vitamin and calcium intake, and nutritional effects on bone formation. Recent studies demonstrate that estrogen itself is inadequate to increase bone density in a majority of patients with anorexia nervosa and suggest that nutritionally dependent factors such as insulin-like growth factor-I (IGF-I), a potent bone trophic hormone, may be important in maintaining bone mass. IT is hoped that new anabolic strategies to increase osteoblast function will become available in the future. In the interim, weight gain, restoration of gonadal function, and calcium supplementation remain the cornerstones of treatment in this disease. SN - 0048-5764 UR - https://www.unboundmedicine.com/medline/citation/9550884/Mechanisms_and_treatment_options_for_bone_loss_in_anorexia_nervosa_ L2 - https://medlineplus.gov/osteoporosis.html DB - PRIME DP - Unbound Medicine ER -