Tags

Type your tag names separated by a space and hit enter

Controlled-release tablet matrices from carrageenans: compression and dissolution studies.
Pharm Dev Technol. 1997 Nov; 2(4):383-93.PD

Abstract

This study investigates the potential of two commercial carrageenans, Gelcarin GP-379 (iota-carrageenan) and Viscarin GP-209 (lambda-carrageenan) to be used for the preparation of controlled-release tablet matrices. Tablets were compressed on an instrumented Stokes single punch machine and compression characteristics of the carrageenans were analyzed. Heckel plots using out-of-die tablet densities were linear with calculated yield pressures of 81.3 MPa and 105.2 MPa for iota- and lambda-carrageenan, respectively. Drug release from tablet formulations that contained equal amounts of the two carrageenans had near zero-order release profiles. There was little or no effect of tablet compression pressure on the drug release profiles from 70 to 175 MPa. As drug loading was increased from 5 to 20%, the diffusional exponent decreased from 1.056 to 0.678. Thirty percent drug loading resulted in breakup of tablets during dissolution and departure from zero-order release. Multiple regression analysis was used to predict the time for 50% release as a function of the concentration of the two carrageenans and a third filler material, microcrystalline cellulose. Predicted values were in good agreement with observed values and R2 for the final cubic model was 0.9984.

Links

Publisher Full Text

Authors+Show Affiliations

Hariharan M
Department of Pharmaceutics, University of Georgia, Athens 30602, USA.
Wheatley TA
No affiliation info available
Price JC
No affiliation info available

MeSH

CarrageenanCompressive StrengthDelayed-Action PreparationsExcipientsLinear ModelsSolubilityTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9552467

Citation

Hariharan, M, et al. "Controlled-release Tablet Matrices From Carrageenans: Compression and Dissolution Studies." Pharmaceutical Development and Technology, vol. 2, no. 4, 1997, pp. 383-93.
Hariharan M, Wheatley TA, Price JC. Controlled-release tablet matrices from carrageenans: compression and dissolution studies. Pharm Dev Technol. 1997;2(4):383-93.
Hariharan, M., Wheatley, T. A., & Price, J. C. (1997). Controlled-release tablet matrices from carrageenans: compression and dissolution studies. Pharmaceutical Development and Technology, 2(4), 383-93.
Hariharan M, Wheatley TA, Price JC. Controlled-release Tablet Matrices From Carrageenans: Compression and Dissolution Studies. Pharm Dev Technol. 1997;2(4):383-93. PubMed PMID: 9552467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled-release tablet matrices from carrageenans: compression and dissolution studies. AU - Hariharan,M, AU - Wheatley,T A, AU - Price,J C, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 383 EP - 93 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 2 IS - 4 N2 - This study investigates the potential of two commercial carrageenans, Gelcarin GP-379 (iota-carrageenan) and Viscarin GP-209 (lambda-carrageenan) to be used for the preparation of controlled-release tablet matrices. Tablets were compressed on an instrumented Stokes single punch machine and compression characteristics of the carrageenans were analyzed. Heckel plots using out-of-die tablet densities were linear with calculated yield pressures of 81.3 MPa and 105.2 MPa for iota- and lambda-carrageenan, respectively. Drug release from tablet formulations that contained equal amounts of the two carrageenans had near zero-order release profiles. There was little or no effect of tablet compression pressure on the drug release profiles from 70 to 175 MPa. As drug loading was increased from 5 to 20%, the diffusional exponent decreased from 1.056 to 0.678. Thirty percent drug loading resulted in breakup of tablets during dissolution and departure from zero-order release. Multiple regression analysis was used to predict the time for 50% release as a function of the concentration of the two carrageenans and a third filler material, microcrystalline cellulose. Predicted values were in good agreement with observed values and R2 for the final cubic model was 0.9984. SN - 1083-7450 UR - https://www.unboundmedicine.com/medline/citation/9552467/Controlled_release_tablet_matrices_from_carrageenans:_compression_and_dissolution_studies_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837459709022637 DB - PRIME DP - Unbound Medicine ER -