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[Hydroxyethyl starch--an interim report].
Anaesthesiol Reanim. 1998; 23(1):4-14.AR

Abstract

Since the beginning of this century, a few biopolymers have been used as basic materials for volume substitution. Aside from gelatin and dextran, modified starch (hydroxyethyl starch, HES) is currently the first-choice means. Due to special manufacturing processes, different hydroxyethyl starches are now available. They have several different characteristics and produce different clinical effects. These clinical properties depend on the average molecular weight and the distribution of molecular weight as well as on the degree and pattern of substitution. The duration of volume effect, one of the most important parameters for the effectiveness of a volume substitute, depends to a large degree on the substitution. Elimination of HES from serum is delayed by a high degree of substitution and a high C2/C6 ratio of the substitution pattern. The molecular parameters of HES also influence other effects, such as cumulation in various organs and hemostasis. Critical reading of current HES literature shows that many questions still have to be answered. At the same time ways and means of optimizing differential volume substitution therapy and hemodilution therapy are emerging.

Authors

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Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

9553245

Citation

Weidhase, R, et al. "[Hydroxyethyl Starch--an Interim Report]." Anaesthesiologie Und Reanimation, vol. 23, no. 1, 1998, pp. 4-14.
Weidhase R, Faude K, Weidhase R. [Hydroxyethyl starch--an interim report]. Anaesthesiol Reanim. 1998;23(1):4-14.
Weidhase, R., Faude, K., & Weidhase, R. (1998). [Hydroxyethyl starch--an interim report]. Anaesthesiologie Und Reanimation, 23(1), 4-14.
Weidhase R, Faude K, Weidhase R. [Hydroxyethyl Starch--an Interim Report]. Anaesthesiol Reanim. 1998;23(1):4-14. PubMed PMID: 9553245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hydroxyethyl starch--an interim report]. AU - Weidhase,R, AU - Faude,K, AU - Weidhase,R, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 4 EP - 14 JF - Anaesthesiologie und Reanimation JO - Anaesthesiol Reanim VL - 23 IS - 1 N2 - Since the beginning of this century, a few biopolymers have been used as basic materials for volume substitution. Aside from gelatin and dextran, modified starch (hydroxyethyl starch, HES) is currently the first-choice means. Due to special manufacturing processes, different hydroxyethyl starches are now available. They have several different characteristics and produce different clinical effects. These clinical properties depend on the average molecular weight and the distribution of molecular weight as well as on the degree and pattern of substitution. The duration of volume effect, one of the most important parameters for the effectiveness of a volume substitute, depends to a large degree on the substitution. Elimination of HES from serum is delayed by a high degree of substitution and a high C2/C6 ratio of the substitution pattern. The molecular parameters of HES also influence other effects, such as cumulation in various organs and hemostasis. Critical reading of current HES literature shows that many questions still have to be answered. At the same time ways and means of optimizing differential volume substitution therapy and hemodilution therapy are emerging. SN - 0323-4983 UR - https://www.unboundmedicine.com/medline/citation/9553245/[Hydroxyethyl_starch__an_interim_report]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:9553245 DB - PRIME DP - Unbound Medicine ER -