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A prospective, randomized 1-year clinical trial comparing transurethral needle ablation to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia.
J Urol. 1998 May; 159(5):1588-93; discussion 1593-4.JU

Abstract

PURPOSE

We assess the 1-year efficacy and safety of transurethral needle ablation of the prostate compared to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia (BPH).

MATERIALS AND METHODS

A prospective, randomized clinical trial of 121 men 50 years old or older with symptomatic BPH was performed at 7 medical centers across the United States. Of the men 65 (54%) were treated with transurethral needle ablation of the prostate and 56 (46%) underwent transurethral resection of the prostate. Mean and percentage changes from baseline and between cohorts for American Urological Association (AUA) symptom score, AUA bother score, quality of life score, peak urinary flow rate and post-void residual urine volume were measured at 1, 3, 6 and 12 months following treatment. Length of procedure, hospitalization, type of anesthesia, post-procedure catheterization, side effects and sexual function were compared.

RESULTS

Transurethral needle ablation and resection resulted in a statistically significant improvement in AUA symptom, bother and quality of life scores, peak urinary flow rate and post-void residual. At 1-year followup, needle ablation and resection were equally effective in enhancing quality of life. Needle ablation had less effect on sexual function, with resection being associated with a greater incidence of retrograde ejaculation. Needle ablation could be performed as an outpatient procedure with local anesthesia while resection required anesthesia and hospitalization. Needle ablation was associated with markedly fewer side effects than resection.

CONCLUSIONS

Compared to transurethral resection of the prostate, transurethral needle ablation of the prostate is an efficacious, minimally invasive treatment for symptomatic BPH that is associated with few side effects.

Authors+Show Affiliations

University of Wisconsin Hospital and Clinics, Madison, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9554360

Citation

Bruskewitz, R, et al. "A Prospective, Randomized 1-year Clinical Trial Comparing Transurethral Needle Ablation to Transurethral Resection of the Prostate for the Treatment of Symptomatic Benign Prostatic Hyperplasia." The Journal of Urology, vol. 159, no. 5, 1998, pp. 1588-93; discussion 1593-4.
Bruskewitz R, Issa MM, Roehrborn CG, et al. A prospective, randomized 1-year clinical trial comparing transurethral needle ablation to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia. J Urol. 1998;159(5):1588-93; discussion 1593-4.
Bruskewitz, R., Issa, M. M., Roehrborn, C. G., Naslund, M. J., Perez-Marrero, R., Shumaker, B. P., & Oesterling, J. E. (1998). A prospective, randomized 1-year clinical trial comparing transurethral needle ablation to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia. The Journal of Urology, 159(5), 1588-93; discussion 1593-4.
Bruskewitz R, et al. A Prospective, Randomized 1-year Clinical Trial Comparing Transurethral Needle Ablation to Transurethral Resection of the Prostate for the Treatment of Symptomatic Benign Prostatic Hyperplasia. J Urol. 1998;159(5):1588-93; discussion 1593-4. PubMed PMID: 9554360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective, randomized 1-year clinical trial comparing transurethral needle ablation to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia. AU - Bruskewitz,R, AU - Issa,M M, AU - Roehrborn,C G, AU - Naslund,M J, AU - Perez-Marrero,R, AU - Shumaker,B P, AU - Oesterling,J E, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 1588-93; discussion 1593-4 JF - The Journal of urology JO - J Urol VL - 159 IS - 5 N2 - PURPOSE: We assess the 1-year efficacy and safety of transurethral needle ablation of the prostate compared to transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: A prospective, randomized clinical trial of 121 men 50 years old or older with symptomatic BPH was performed at 7 medical centers across the United States. Of the men 65 (54%) were treated with transurethral needle ablation of the prostate and 56 (46%) underwent transurethral resection of the prostate. Mean and percentage changes from baseline and between cohorts for American Urological Association (AUA) symptom score, AUA bother score, quality of life score, peak urinary flow rate and post-void residual urine volume were measured at 1, 3, 6 and 12 months following treatment. Length of procedure, hospitalization, type of anesthesia, post-procedure catheterization, side effects and sexual function were compared. RESULTS: Transurethral needle ablation and resection resulted in a statistically significant improvement in AUA symptom, bother and quality of life scores, peak urinary flow rate and post-void residual. At 1-year followup, needle ablation and resection were equally effective in enhancing quality of life. Needle ablation had less effect on sexual function, with resection being associated with a greater incidence of retrograde ejaculation. Needle ablation could be performed as an outpatient procedure with local anesthesia while resection required anesthesia and hospitalization. Needle ablation was associated with markedly fewer side effects than resection. CONCLUSIONS: Compared to transurethral resection of the prostate, transurethral needle ablation of the prostate is an efficacious, minimally invasive treatment for symptomatic BPH that is associated with few side effects. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/9554360/A_prospective_randomized_1_year_clinical_trial_comparing_transurethral_needle_ablation_to_transurethral_resection_of_the_prostate_for_the_treatment_of_symptomatic_benign_prostatic_hyperplasia_ L2 - https://www.jurology.com/doi/10.1097/00005392-199805000-00048?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -