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[Nitric oxide inhalation in newborn infants with pulmonary hypertension].
Ned Tijdschr Geneeskd. 1998 Jan 17; 142(3):123-7.NT

Abstract

Nitric oxide (NO) is an important endogenous vasodilator. NO, produced in the endothelial cell, causes vasodilation by relaxation of the vascular smooth muscle cell. Inhalation of NO plays a role in the treatment of persistent pulmonary hypertension of the newborn, a syndrome with considerable morbidity and mortality. NO inhalation specifically leads to pulmonary vasodilation without systemic hypotension, since NO binds avidly to haemoglobin. Neonates with pulmonary hypertension associated with lung hypoplasia, meconium aspiration syndrome, infantile inspiratory distress syndrome due to surfactant deficiency, and sepsis have been treated with inhaled NO. Literature data on NO inhalation and experience in our units with NO inhalation show an improvement in arterial oxygen tension and a decreased need for extracorporeal membrane oxygenation, but no reduction in mortality. NO toxicity as a result of NO inhalation in the newborn has not been reported yet.

Authors+Show Affiliations

de Beaufort AJ
Academisch Ziekenhuis, afd. Neonatologie, Leiden.
Slot HM
No affiliation info available
van Bel F
No affiliation info available

MeSH

Administration, InhalationExtracorporeal Membrane OxygenationHumansInfant, NewbornLungMeconium Aspiration SyndromeNitric OxidePersistent Fetal Circulation SyndromePneumoniaPulmonary CirculationRespiratory Distress Syndrome, NewbornVasodilation

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

9557009

Citation

de Beaufort, A J., et al. "[Nitric Oxide Inhalation in Newborn Infants With Pulmonary Hypertension]." Nederlands Tijdschrift Voor Geneeskunde, vol. 142, no. 3, 1998, pp. 123-7.
de Beaufort AJ, Slot HM, van Bel F. [Nitric oxide inhalation in newborn infants with pulmonary hypertension]. Ned Tijdschr Geneeskd. 1998;142(3):123-7.
de Beaufort, A. J., Slot, H. M., & van Bel, F. (1998). [Nitric oxide inhalation in newborn infants with pulmonary hypertension]. Nederlands Tijdschrift Voor Geneeskunde, 142(3), 123-7.
de Beaufort AJ, Slot HM, van Bel F. [Nitric Oxide Inhalation in Newborn Infants With Pulmonary Hypertension]. Ned Tijdschr Geneeskd. 1998 Jan 17;142(3):123-7. PubMed PMID: 9557009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nitric oxide inhalation in newborn infants with pulmonary hypertension]. AU - de Beaufort,A J, AU - Slot,H M, AU - van Bel,F, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 123 EP - 7 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 142 IS - 3 N2 - Nitric oxide (NO) is an important endogenous vasodilator. NO, produced in the endothelial cell, causes vasodilation by relaxation of the vascular smooth muscle cell. Inhalation of NO plays a role in the treatment of persistent pulmonary hypertension of the newborn, a syndrome with considerable morbidity and mortality. NO inhalation specifically leads to pulmonary vasodilation without systemic hypotension, since NO binds avidly to haemoglobin. Neonates with pulmonary hypertension associated with lung hypoplasia, meconium aspiration syndrome, infantile inspiratory distress syndrome due to surfactant deficiency, and sepsis have been treated with inhaled NO. Literature data on NO inhalation and experience in our units with NO inhalation show an improvement in arterial oxygen tension and a decreased need for extracorporeal membrane oxygenation, but no reduction in mortality. NO toxicity as a result of NO inhalation in the newborn has not been reported yet. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/9557009/[Nitric_oxide_inhalation_in_newborn_infants_with_pulmonary_hypertension]_ L2 - http://www.diseaseinfosearch.org/result/6088 DB - PRIME DP - Unbound Medicine ER -