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Frequency of foetal haemoglobin and haemoglobin values in various haemoglobin genotypes in Calabar, Nigeria.
East Afr Med J. 1997 Dec; 74(12):809-11.EA

Abstract

The frequency of foetal haemoglobin (HbF) and haemoglobin (Hb) levels were determined among 108 subjects with different haemoglobin genotypes in Calabar, between March and October, 1996. Hb-genotype was determined using the cellulose acetate method, while HbF and Hb were estimated using the modified Betke alkaline denaturation method and cyanmethaemoglobin techniques respectively. Haemoglobin genotype SS individuals had the highest mean HbF concentration of (3.05 +/- 1.61) as compared to AA and AS subjects with means of 0.195 +/- 0.25 and 1.072 +/- 0.98 respectively. This relationship was statistically significant (P < 0.02). On the other hand, AA subjects had the highest mean haemoglobin concentration (12.79 +/- 1.19) while SS subjects had the lowest (10.65 +/- 2.06). This study has indicated the persistence of HbF into adult life in this locality. Since HbF is associated with natural anti-sickling properties, its role as a monitoring factor in the management of sickle cell anaemia is examined in detail.

Authors+Show Affiliations

Department of Haematology, College of Medical Sciences, University of Calabar, Nigeria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9557428

Citation

Uko, E K., et al. "Frequency of Foetal Haemoglobin and Haemoglobin Values in Various Haemoglobin Genotypes in Calabar, Nigeria." East African Medical Journal, vol. 74, no. 12, 1997, pp. 809-11.
Uko EK, Useh MF, Gwanmesia FN. Frequency of foetal haemoglobin and haemoglobin values in various haemoglobin genotypes in Calabar, Nigeria. East Afr Med J. 1997;74(12):809-11.
Uko, E. K., Useh, M. F., & Gwanmesia, F. N. (1997). Frequency of foetal haemoglobin and haemoglobin values in various haemoglobin genotypes in Calabar, Nigeria. East African Medical Journal, 74(12), 809-11.
Uko EK, Useh MF, Gwanmesia FN. Frequency of Foetal Haemoglobin and Haemoglobin Values in Various Haemoglobin Genotypes in Calabar, Nigeria. East Afr Med J. 1997;74(12):809-11. PubMed PMID: 9557428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of foetal haemoglobin and haemoglobin values in various haemoglobin genotypes in Calabar, Nigeria. AU - Uko,E K, AU - Useh,M F, AU - Gwanmesia,F N, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 809 EP - 11 JF - East African medical journal JO - East Afr Med J VL - 74 IS - 12 N2 - The frequency of foetal haemoglobin (HbF) and haemoglobin (Hb) levels were determined among 108 subjects with different haemoglobin genotypes in Calabar, between March and October, 1996. Hb-genotype was determined using the cellulose acetate method, while HbF and Hb were estimated using the modified Betke alkaline denaturation method and cyanmethaemoglobin techniques respectively. Haemoglobin genotype SS individuals had the highest mean HbF concentration of (3.05 +/- 1.61) as compared to AA and AS subjects with means of 0.195 +/- 0.25 and 1.072 +/- 0.98 respectively. This relationship was statistically significant (P < 0.02). On the other hand, AA subjects had the highest mean haemoglobin concentration (12.79 +/- 1.19) while SS subjects had the lowest (10.65 +/- 2.06). This study has indicated the persistence of HbF into adult life in this locality. Since HbF is associated with natural anti-sickling properties, its role as a monitoring factor in the management of sickle cell anaemia is examined in detail. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/9557428/Frequency_of_foetal_haemoglobin_and_haemoglobin_values_in_various_haemoglobin_genotypes_in_Calabar_Nigeria_ DB - PRIME DP - Unbound Medicine ER -