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A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women.

Abstract

OBJECTIVE

To investigate the interactive effects of oral contraceptive pill use and dietary fat intake on cardiovascular haemodynamics and metabolic parameters in young normotensive women.

DESIGN

Thirty-two women participated, of whom 16 were taking oral contraceptive pills (ethinyl-oestradiol plus levonorgestrel) and 16 were age-matched and weight-matched controls not taking such pills. Subjects consumed either a high-fat or a low-fat diet for 2 weeks in an open, randomized, crossover study lasting 6 weeks. Investigations were performed at the end of each diet during the luteal phase of the menstrual cycle.

METHODS

Blood pressure was measured by 24 h ambulatory recording; cardiovascular reactivity was determined by examining blood pressure responses to systemic infusions of noradrenaline and angiotensin II and to the cold pressor test; and carbohydrate metabolism was investigated by an intravenous glucose-tolerance test.

RESULTS

Plasma triglyceride levels were significantly higher in women taking oral contraceptive pills compared with non-users on both diets; however, responses of lipoprotein levels to the two diets did not differ between study groups (total and low-density lipoprotein cholesterol levels decreased by 15 and 17% in oral contraceptive pill users and by 14% each in non-users, on the low-fat compared with the high-fat diet). Fasting plasma insulin levels, the insulin-production response to administration of glucose (insulin area under the curve) and resting clinic and night-time systolic blood pressures were all significantly reduced on the low-fat diet, but only in non-users. Blood pressure responses to noradrenaline and maximal heart rate response to cold were significantly attenuated during the low-fat diet in oral contraceptive pill users. During the low-fat diet, resting systolic, 24 h systolic and diastolic blood pressures and insulin area under the curve were all significantly higher for women taking the oral contraceptive pills. Users of these pills also exhibited a greater systolic sensitivity to administration both of noradrenaline and of angiotensin II and had a higher plasma renin activity irrespective of dietary phase.

CONCLUSIONS

These results confirm that oral contraceptive pills have the potential to cause adverse effects on blood pressure, cardiovascular reactivity and the insulin-production response to administration of glucose and suggest that some of the beneficial effects of a low-fat diet on these parameters may be negated in women taking oral contraceptive pills.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine, University of Melbourne, Austin Repatriation Medical Centre, Heidelberg, Victoria, Australia.

    , ,

    Source

    Journal of hypertension 16:3 1998 Mar pg 357-68

    MeSH

    Adult
    Blood Glucose
    Blood Pressure
    Cardiovascular System
    Contraceptives, Oral
    Cross-Over Studies
    Diet, Fat-Restricted
    Dietary Fats
    Female
    Glucose Tolerance Test
    Heart Rate
    Humans
    Insulin
    Lipids
    Norepinephrine
    Renin
    Triglycerides

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9557929

    Citation

    Straznicky, N E., et al. "A Study of the Interactive Effects of Oral Contraceptive Use and Dietary Fat Intake On Blood Pressure, Cardiovascular Reactivity and Glucose Tolerance in Normotensive Women." Journal of Hypertension, vol. 16, no. 3, 1998, pp. 357-68.
    Straznicky NE, Barrington VE, Branley P, et al. A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women. J Hypertens. 1998;16(3):357-68.
    Straznicky, N. E., Barrington, V. E., Branley, P., & Louis, W. J. (1998). A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women. Journal of Hypertension, 16(3), pp. 357-68.
    Straznicky NE, et al. A Study of the Interactive Effects of Oral Contraceptive Use and Dietary Fat Intake On Blood Pressure, Cardiovascular Reactivity and Glucose Tolerance in Normotensive Women. J Hypertens. 1998;16(3):357-68. PubMed PMID: 9557929.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women. AU - Straznicky,N E, AU - Barrington,V E, AU - Branley,P, AU - Louis,W J, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez KW - Australia KW - Biology KW - Blood Pressure KW - Carbohydrate Metabolic Effects KW - Cardiovascular Effects KW - Clinical Research KW - Contraception KW - Contraceptive Methods--side effects KW - Developed Countries KW - Diet KW - Examinations And Diagnoses KW - Family Planning KW - Glucose Metabolism Effects KW - Glucose Tolerance Test KW - Health KW - Hemic System KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Metabolic Effects KW - Nutrition KW - Oceania KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Research Report SP - 357 EP - 68 JF - Journal of hypertension JO - J. Hypertens. VL - 16 IS - 3 N2 - OBJECTIVE: To investigate the interactive effects of oral contraceptive pill use and dietary fat intake on cardiovascular haemodynamics and metabolic parameters in young normotensive women. DESIGN: Thirty-two women participated, of whom 16 were taking oral contraceptive pills (ethinyl-oestradiol plus levonorgestrel) and 16 were age-matched and weight-matched controls not taking such pills. Subjects consumed either a high-fat or a low-fat diet for 2 weeks in an open, randomized, crossover study lasting 6 weeks. Investigations were performed at the end of each diet during the luteal phase of the menstrual cycle. METHODS: Blood pressure was measured by 24 h ambulatory recording; cardiovascular reactivity was determined by examining blood pressure responses to systemic infusions of noradrenaline and angiotensin II and to the cold pressor test; and carbohydrate metabolism was investigated by an intravenous glucose-tolerance test. RESULTS: Plasma triglyceride levels were significantly higher in women taking oral contraceptive pills compared with non-users on both diets; however, responses of lipoprotein levels to the two diets did not differ between study groups (total and low-density lipoprotein cholesterol levels decreased by 15 and 17% in oral contraceptive pill users and by 14% each in non-users, on the low-fat compared with the high-fat diet). Fasting plasma insulin levels, the insulin-production response to administration of glucose (insulin area under the curve) and resting clinic and night-time systolic blood pressures were all significantly reduced on the low-fat diet, but only in non-users. Blood pressure responses to noradrenaline and maximal heart rate response to cold were significantly attenuated during the low-fat diet in oral contraceptive pill users. During the low-fat diet, resting systolic, 24 h systolic and diastolic blood pressures and insulin area under the curve were all significantly higher for women taking the oral contraceptive pills. Users of these pills also exhibited a greater systolic sensitivity to administration both of noradrenaline and of angiotensin II and had a higher plasma renin activity irrespective of dietary phase. CONCLUSIONS: These results confirm that oral contraceptive pills have the potential to cause adverse effects on blood pressure, cardiovascular reactivity and the insulin-production response to administration of glucose and suggest that some of the beneficial effects of a low-fat diet on these parameters may be negated in women taking oral contraceptive pills. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/9557929/A_study_of_the_interactive_effects_of_oral_contraceptive_use_and_dietary_fat_intake_on_blood_pressure_cardiovascular_reactivity_and_glucose_tolerance_in_normotensive_women_ L2 - http://Insights.ovid.com/pubmed?pmid=9557929 DB - PRIME DP - Unbound Medicine ER -