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Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?
Free Radic Biol Med. 1998 Mar 01; 24(4):594-606.FR

Abstract

Peroxynitrite is a cytotoxic species generated by the reaction between superoxide and nitric oxide. In this study the ability of hydroxycinnamate antioxidants to decrease peroxynitrite-mediated nitration of tyrosine was investigated. The results obtained show that all compounds were able to inhibit nitration of tyrosine. The potency of inhibitory activity was in the order; caffeic acid > or = chlorogenic acid > or = ferulic acid > p-coumaric acid > ocoumaric acid > m-coumaric acid. Trolox, which was included in the study for comparative purposes, had an activity between that of ferulic acid and p-coumaric acid. The data obtained suggest that hydroxycinnamates can act by one of two possible mechanisms: preferential nitration for monophenolates and electron donation by catecholates.

Authors+Show Affiliations

International Antioxidant Research Centre, Department of Pharmacy, King's College, University of London, Chelsea, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9559872

Citation

Pannala, A S., et al. "Inhibition of Peroxynitrite Dependent Tyrosine Nitration By Hydroxycinnamates: Nitration or Electron Donation?" Free Radical Biology & Medicine, vol. 24, no. 4, 1998, pp. 594-606.
Pannala AS, Razaq R, Halliwell B, et al. Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation? Free Radic Biol Med. 1998;24(4):594-606.
Pannala, A. S., Razaq, R., Halliwell, B., Singh, S., & Rice-Evans, C. A. (1998). Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation? Free Radical Biology & Medicine, 24(4), 594-606.
Pannala AS, et al. Inhibition of Peroxynitrite Dependent Tyrosine Nitration By Hydroxycinnamates: Nitration or Electron Donation. Free Radic Biol Med. 1998 Mar 1;24(4):594-606. PubMed PMID: 9559872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation? AU - Pannala,A S, AU - Razaq,R, AU - Halliwell,B, AU - Singh,S, AU - Rice-Evans,C A, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 594 EP - 606 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 24 IS - 4 N2 - Peroxynitrite is a cytotoxic species generated by the reaction between superoxide and nitric oxide. In this study the ability of hydroxycinnamate antioxidants to decrease peroxynitrite-mediated nitration of tyrosine was investigated. The results obtained show that all compounds were able to inhibit nitration of tyrosine. The potency of inhibitory activity was in the order; caffeic acid > or = chlorogenic acid > or = ferulic acid > p-coumaric acid > ocoumaric acid > m-coumaric acid. Trolox, which was included in the study for comparative purposes, had an activity between that of ferulic acid and p-coumaric acid. The data obtained suggest that hydroxycinnamates can act by one of two possible mechanisms: preferential nitration for monophenolates and electron donation by catecholates. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/9559872/Inhibition_of_peroxynitrite_dependent_tyrosine_nitration_by_hydroxycinnamates:_nitration_or_electron_donation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891584997003213 DB - PRIME DP - Unbound Medicine ER -