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5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion.
Neuroreport. 1998 Mar 09; 9(4):641-5.N

Abstract

To investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties.

Authors+Show Affiliations

Graduate School Neurosciences Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9559931

Citation

Bonaventure, P, et al. "5HT1B and 5HT1D Receptor mRNA Differential Co-localization With Peptide mRNA in the Guinea Pig Trigeminal Ganglion." Neuroreport, vol. 9, no. 4, 1998, pp. 641-5.
Bonaventure P, Voorn P, Luyten WH, et al. 5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion. Neuroreport. 1998;9(4):641-5.
Bonaventure, P., Voorn, P., Luyten, W. H., & Leysen, J. E. (1998). 5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion. Neuroreport, 9(4), 641-5.
Bonaventure P, et al. 5HT1B and 5HT1D Receptor mRNA Differential Co-localization With Peptide mRNA in the Guinea Pig Trigeminal Ganglion. Neuroreport. 1998 Mar 9;9(4):641-5. PubMed PMID: 9559931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion. AU - Bonaventure,P, AU - Voorn,P, AU - Luyten,W H, AU - Leysen,J E, PY - 1998/4/29/pubmed PY - 1998/4/29/medline PY - 1998/4/29/entrez SP - 641 EP - 5 JF - Neuroreport JO - Neuroreport VL - 9 IS - 4 N2 - To investigate the possible role of 5HT1B and/or 5HT1D receptors in controlling neurogenic inflammation, we performed a co-localization study of the mRNA for 5HT1B and 5HT1D receptors and of substance P or calcitonin gene-related peptide (CGRP) mRNA in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. The 5HT1D receptor mRNA is abundant whereas 5HT1B receptor mRNA is scarce. The vast majority of cells containing substance P mRNA also contained 5HT1B receptor mRNA, but very few cells expressed substance P mRNA and 5HT1D receptor mRNA. Both receptor mRNAs were co-localized with CGRP mRNA. Hence, 5HT1D receptors may control the release of CGRP only, whereas 5HT1B receptors may control the release of both substance P and CGRP. The question remains whether selective 5HT1D agonists will have migraine abortive properties. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/9559931/5HT1B_and_5HT1D_receptor_mRNA_differential_co_localization_with_peptide_mRNA_in_the_guinea_pig_trigeminal_ganglion_ L2 - http://dx.doi.org/10.1097/00001756-199803090-00015 DB - PRIME DP - Unbound Medicine ER -