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Hypervolemia in men from fluid ingestion at rest and during exercise.
Aviat Space Environ Med. 1998 Apr; 69(4):374-86.AS

Abstract

BACKGROUND

Plasma osmolality (Osm) is important for controlling and maintaining plasma volume (PV) and body water. The effect of oral rehydration fluids for ameliorating dehydration is well-established; but optimal composition and Osm of fluids for hyperhydrating normally hydrated subjects is less clear.

METHODS

Six treatments were used without and with oral fluids of varying ionic and constituent concentrations for hyperhydrating six previously euhydrated men (30 +/- SD 8 yr, 76.84 +/- 16.19 kg, 73 +/- 12 ml.kg-1 PV, 40 +/- 10 ml.min-1.kg-1 peak VO2) sitting at rest for 90 min (VO2 = 0.39 +/- SE 0.02 L.min-1) and during subsequent 70 min of submaximal exercise (VO2 = 2.08 +/- SE 0.33 L.min-1, 70 +/- 7% peak VO2). The hypothesis was that the fluid composition is more important than plasma Osm for increasing PV in euhydrated subjects at rest and maintaining it during exercise. Drink formulation compositions, given at 10 ml.kg-1 body wt, (mean = 768 ml), for the sitting period were: Performance 1 (P1; 55 mEq Na+, 365 mOsm.kg H2O-1), P2 (97 mEq Na+, 791 mOsm.kg-1), P2G (113 mEq Na+, 4% glycerol, 1382 mOsm.kg-1), AstroAde (AA; 164 mEq Na+, 253 mOsm.kg-1), and 01 and 02 (no drinking). The exercise drink (10 ml.kg-1, 768 ml) was P1 for all treatments except 02 (no drinking); thus, drink designations were: P1/P1, P2/P1, P2G/P1, AA/P1, 0/P1, and 0/0.

RESULTS

PV at rest increased (p < 0.05) by 4.7% with P1 and by 7.9% with AA. Percent change in PV during exercise was +1% to +3% (NS) with AA/P1; -6% to 0% (NS) with P1/P1, P2/P1, P2G/P1, and 0/P1; and -8% to -5% (p < 0.05) with 0/0. AA, with the lowest Osm of 253 mOsm.kg-1, increased PV at rest (as did P1) and maintained it during exercise, whereas the other drinks with lower Na+ and higher Osm of 365-1382 mOsm.kg-1 did not.

CONCLUSION

Drink composition appears to be more important than its Osm for increasing PV at rest and for maintaining it during exercise in previously euhydrated subjects.

Authors+Show Affiliations

Gravitational Research Branch (239-11), NASA, Ames Research Center, Moffett Field, CA 94035-1000, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9561285

Citation

Greenleaf, J E., et al. "Hypervolemia in Men From Fluid Ingestion at Rest and During Exercise." Aviation, Space, and Environmental Medicine, vol. 69, no. 4, 1998, pp. 374-86.
Greenleaf JE, Looft-Wilson R, Wisherd JL, et al. Hypervolemia in men from fluid ingestion at rest and during exercise. Aviat Space Environ Med. 1998;69(4):374-86.
Greenleaf, J. E., Looft-Wilson, R., Wisherd, J. L., Jackson, C. G., Fung, P. P., Ertl, A. C., Barnes, P. R., Jensen, C. D., & Whittam, J. H. (1998). Hypervolemia in men from fluid ingestion at rest and during exercise. Aviation, Space, and Environmental Medicine, 69(4), 374-86.
Greenleaf JE, et al. Hypervolemia in Men From Fluid Ingestion at Rest and During Exercise. Aviat Space Environ Med. 1998;69(4):374-86. PubMed PMID: 9561285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypervolemia in men from fluid ingestion at rest and during exercise. AU - Greenleaf,J E, AU - Looft-Wilson,R, AU - Wisherd,J L, AU - Jackson,C G, AU - Fung,P P, AU - Ertl,A C, AU - Barnes,P R, AU - Jensen,C D, AU - Whittam,J H, PY - 1998/4/30/pubmed PY - 1998/4/30/medline PY - 1998/4/30/entrez KW - NASA Center ARC KW - NASA Discipline Regulatory Physiology SP - 374 EP - 86 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 69 IS - 4 N2 - BACKGROUND: Plasma osmolality (Osm) is important for controlling and maintaining plasma volume (PV) and body water. The effect of oral rehydration fluids for ameliorating dehydration is well-established; but optimal composition and Osm of fluids for hyperhydrating normally hydrated subjects is less clear. METHODS: Six treatments were used without and with oral fluids of varying ionic and constituent concentrations for hyperhydrating six previously euhydrated men (30 +/- SD 8 yr, 76.84 +/- 16.19 kg, 73 +/- 12 ml.kg-1 PV, 40 +/- 10 ml.min-1.kg-1 peak VO2) sitting at rest for 90 min (VO2 = 0.39 +/- SE 0.02 L.min-1) and during subsequent 70 min of submaximal exercise (VO2 = 2.08 +/- SE 0.33 L.min-1, 70 +/- 7% peak VO2). The hypothesis was that the fluid composition is more important than plasma Osm for increasing PV in euhydrated subjects at rest and maintaining it during exercise. Drink formulation compositions, given at 10 ml.kg-1 body wt, (mean = 768 ml), for the sitting period were: Performance 1 (P1; 55 mEq Na+, 365 mOsm.kg H2O-1), P2 (97 mEq Na+, 791 mOsm.kg-1), P2G (113 mEq Na+, 4% glycerol, 1382 mOsm.kg-1), AstroAde (AA; 164 mEq Na+, 253 mOsm.kg-1), and 01 and 02 (no drinking). The exercise drink (10 ml.kg-1, 768 ml) was P1 for all treatments except 02 (no drinking); thus, drink designations were: P1/P1, P2/P1, P2G/P1, AA/P1, 0/P1, and 0/0. RESULTS: PV at rest increased (p < 0.05) by 4.7% with P1 and by 7.9% with AA. Percent change in PV during exercise was +1% to +3% (NS) with AA/P1; -6% to 0% (NS) with P1/P1, P2/P1, P2G/P1, and 0/P1; and -8% to -5% (p < 0.05) with 0/0. AA, with the lowest Osm of 253 mOsm.kg-1, increased PV at rest (as did P1) and maintained it during exercise, whereas the other drinks with lower Na+ and higher Osm of 365-1382 mOsm.kg-1 did not. CONCLUSION: Drink composition appears to be more important than its Osm for increasing PV at rest and for maintaining it during exercise in previously euhydrated subjects. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/9561285/Hypervolemia_in_men_from_fluid_ingestion_at_rest_and_during_exercise_ L2 - https://medlineplus.gov/dehydration.html DB - PRIME DP - Unbound Medicine ER -