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Bone mineral density and menstrual irregularities. A comparative study on cortical and trabecular bone structures in runners with alleged normal eating behavior.
Int J Sports Med. 1998 Feb; 19(2):92-7.IJ

Abstract

Bone mineral density (BMD), and associated biochemical and endocrine markers were compared in a group of runners with menstrual dysfunction (IR, n=13), and a group of performance matched eumenorrheic runners (R, n=15). All subjects claimed to have normal eating habits. Body height and weight, body mass index, and amount of body fat were similar. The IR group consisted of 5 presently oligomenorrheic (O) and 8 presently amenorrheic (A) runners. The BMD values of the athletes were additionally compared with corresponding values in a reference group (C) of healthy age matched controls (n=54). BMD values were significantly lower in IR compared with R on all measuring sites: Total body (-9%, p=0.03), femoral neck (-11%, p=0.01), lumbar spine (-12%, p=0.001), lower leg (-6.5%, p=0.03) and arms (-7%, p=0.01). In addition, IR athletes had lower total body (-5%, p=0.01), and lumbar spine BMD (-10%, p=0.001) than C. No differences were observed in serum IGF-1, SHBG, testosterone and cortisol, or in the biochemical marker of bone formation (osteocalcin) and bone resorption (1 CTP). Values of serum E2, FSH and LH were low in IR and normal in R. TSH was in the normal range in both groups, but f-T4 was significantly lower in IR than in R. The athletes were furthermore grouped according to past and present menstrual dysfunction severity. At all measuring sites, with the exception of the lower leg, increasing menstrual dysfunction severity was linearly associated with declining BMD values (p<0.05). In conclusion, even highly conditioned cortical bone tissue seems to be negatively related to menstrual disorders, which may serve to explain the high incidence of stress fractures in athletes with menstrual disorders. Single measurements of biochemical markers of bone resorption and formation may not reflect the current bone status.

Authors+Show Affiliations

The Norwegian University of Sport and Physical Education, Oslo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9562216

Citation

Tomten, S E., et al. "Bone Mineral Density and Menstrual Irregularities. a Comparative Study On Cortical and Trabecular Bone Structures in Runners With Alleged Normal Eating Behavior." International Journal of Sports Medicine, vol. 19, no. 2, 1998, pp. 92-7.
Tomten SE, Falch JA, Birkeland KI, et al. Bone mineral density and menstrual irregularities. A comparative study on cortical and trabecular bone structures in runners with alleged normal eating behavior. Int J Sports Med. 1998;19(2):92-7.
Tomten, S. E., Falch, J. A., Birkeland, K. I., Hemmersbach, P., & Høstmark, A. T. (1998). Bone mineral density and menstrual irregularities. A comparative study on cortical and trabecular bone structures in runners with alleged normal eating behavior. International Journal of Sports Medicine, 19(2), 92-7.
Tomten SE, et al. Bone Mineral Density and Menstrual Irregularities. a Comparative Study On Cortical and Trabecular Bone Structures in Runners With Alleged Normal Eating Behavior. Int J Sports Med. 1998;19(2):92-7. PubMed PMID: 9562216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density and menstrual irregularities. A comparative study on cortical and trabecular bone structures in runners with alleged normal eating behavior. AU - Tomten,S E, AU - Falch,J A, AU - Birkeland,K I, AU - Hemmersbach,P, AU - Høstmark,A T, PY - 1998/4/30/pubmed PY - 1998/4/30/medline PY - 1998/4/30/entrez SP - 92 EP - 7 JF - International journal of sports medicine JO - Int J Sports Med VL - 19 IS - 2 N2 - Bone mineral density (BMD), and associated biochemical and endocrine markers were compared in a group of runners with menstrual dysfunction (IR, n=13), and a group of performance matched eumenorrheic runners (R, n=15). All subjects claimed to have normal eating habits. Body height and weight, body mass index, and amount of body fat were similar. The IR group consisted of 5 presently oligomenorrheic (O) and 8 presently amenorrheic (A) runners. The BMD values of the athletes were additionally compared with corresponding values in a reference group (C) of healthy age matched controls (n=54). BMD values were significantly lower in IR compared with R on all measuring sites: Total body (-9%, p=0.03), femoral neck (-11%, p=0.01), lumbar spine (-12%, p=0.001), lower leg (-6.5%, p=0.03) and arms (-7%, p=0.01). In addition, IR athletes had lower total body (-5%, p=0.01), and lumbar spine BMD (-10%, p=0.001) than C. No differences were observed in serum IGF-1, SHBG, testosterone and cortisol, or in the biochemical marker of bone formation (osteocalcin) and bone resorption (1 CTP). Values of serum E2, FSH and LH were low in IR and normal in R. TSH was in the normal range in both groups, but f-T4 was significantly lower in IR than in R. The athletes were furthermore grouped according to past and present menstrual dysfunction severity. At all measuring sites, with the exception of the lower leg, increasing menstrual dysfunction severity was linearly associated with declining BMD values (p<0.05). In conclusion, even highly conditioned cortical bone tissue seems to be negatively related to menstrual disorders, which may serve to explain the high incidence of stress fractures in athletes with menstrual disorders. Single measurements of biochemical markers of bone resorption and formation may not reflect the current bone status. SN - 0172-4622 UR - https://www.unboundmedicine.com/medline/citation/9562216/Bone_mineral_density_and_menstrual_irregularities__A_comparative_study_on_cortical_and_trabecular_bone_structures_in_runners_with_alleged_normal_eating_behavior_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-971888 DB - PRIME DP - Unbound Medicine ER -