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Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer.
Cancer Res. 1998 Apr 15; 58(8):1605-8.CR

Abstract

3p deletion, a common chromosome defect in lung cancer, occurs more frequently in the lung tumor tissues of smoking patients than it does in those of nonsmoking patients. This pilot study evaluated whether 3p aberrations induced by benzo[a]pyrene diol epoxide (BPDE), the metabolic product of benzo[a]pyrene, a constituent of tobacco smoke, were more common in the peripheral blood lymphocytes of 40 lung cancer patients than they were in those of 54 matched controls. Our hypothesis was that 3p sensitivity to BPDE reflects the susceptibility of a specific locus to damage from carcinogens in tobacco smoke. BPDE-induced chromosome 3p21.3 aberrations were significantly more frequent in cases (34.1 per 1000) than they were in controls (22.1 per 1000; P < 0.0001). However, no such difference was observed for 6q27, a control locus. Using the median value in the controls (20 per 1000) as a cutoff point to classify BPDE-induced sensitivity at 3p21.3 and after adjustment by age, sex, ethnicity, and smoking status, 3p BPDE sensitivity was associated with an elevated risk of 14.1 (95% confidence interval: 3.5, 56.2) for lung cancer. There was also a dose-response relationship between the degree of BPDE sensitivity at 3p21.3 and increased risk for lung cancer. Therefore, 3p may be a molecular target for BPDE damage in lung cancer cases.

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Authors+Show Affiliations

Wu X
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Zhao Y
No affiliation info available
Honn SE
No affiliation info available
Tomlinson GE
No affiliation info available
Minna JD
No affiliation info available
Hong WK
No affiliation info available
Spitz MR
No affiliation info available

MeSH

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideAgedCells, CulturedChromosome AberrationsChromosomes, Human, Pair 3Disease SusceptibilityDose-Response Relationship, DrugFemaleHumansIn Situ Hybridization, FluorescenceInterphaseLung NeoplasmsLymphocytesMaleMiddle AgedPilot ProjectsRiskSmoking

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9563468

Citation

Wu, X, et al. "Benzo[a]pyrene Diol Epoxide-induced 3p21.3 Aberrations and Genetic Predisposition to Lung Cancer." Cancer Research, vol. 58, no. 8, 1998, pp. 1605-8.
Wu X, Zhao Y, Honn SE, et al. Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer. Cancer Res. 1998;58(8):1605-8.
Wu, X., Zhao, Y., Honn, S. E., Tomlinson, G. E., Minna, J. D., Hong, W. K., & Spitz, M. R. (1998). Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer. Cancer Research, 58(8), 1605-8.
Wu X, et al. Benzo[a]pyrene Diol Epoxide-induced 3p21.3 Aberrations and Genetic Predisposition to Lung Cancer. Cancer Res. 1998 Apr 15;58(8):1605-8. PubMed PMID: 9563468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer. AU - Wu,X, AU - Zhao,Y, AU - Honn,S E, AU - Tomlinson,G E, AU - Minna,J D, AU - Hong,W K, AU - Spitz,M R, PY - 1998/5/1/pubmed PY - 1998/5/1/medline PY - 1998/5/1/entrez SP - 1605 EP - 8 JF - Cancer research JO - Cancer Res VL - 58 IS - 8 N2 - 3p deletion, a common chromosome defect in lung cancer, occurs more frequently in the lung tumor tissues of smoking patients than it does in those of nonsmoking patients. This pilot study evaluated whether 3p aberrations induced by benzo[a]pyrene diol epoxide (BPDE), the metabolic product of benzo[a]pyrene, a constituent of tobacco smoke, were more common in the peripheral blood lymphocytes of 40 lung cancer patients than they were in those of 54 matched controls. Our hypothesis was that 3p sensitivity to BPDE reflects the susceptibility of a specific locus to damage from carcinogens in tobacco smoke. BPDE-induced chromosome 3p21.3 aberrations were significantly more frequent in cases (34.1 per 1000) than they were in controls (22.1 per 1000; P < 0.0001). However, no such difference was observed for 6q27, a control locus. Using the median value in the controls (20 per 1000) as a cutoff point to classify BPDE-induced sensitivity at 3p21.3 and after adjustment by age, sex, ethnicity, and smoking status, 3p BPDE sensitivity was associated with an elevated risk of 14.1 (95% confidence interval: 3.5, 56.2) for lung cancer. There was also a dose-response relationship between the degree of BPDE sensitivity at 3p21.3 and increased risk for lung cancer. Therefore, 3p may be a molecular target for BPDE damage in lung cancer cases. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9563468/Benzo[a]pyrene_diol_epoxide_induced_3p21_3_aberrations_and_genetic_predisposition_to_lung_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=9563468 DB - PRIME DP - Unbound Medicine ER -