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Determinants of aerobic and anaerobic exercise performance in cystic fibrosis.
Am J Respir Crit Care Med 1998; 157(4 Pt 1):1145-50AJ

Abstract

We examined aerobic and anaerobic exercise performance in 17 subjects with cystic fibrosis (CF) (age 25+/-10 [SD] yr; 47% females; FEV1 62+/-21% pred) and 17 age- and sex-matched control subjects (age 25+/-8 [SD] yr; 41% females; FEV1 112+/-15% pred) in relation to pulmonary function and nutritional status. Aerobic capacity was determined as maximal oxygen consumption (VO2max) (ml/kg/min) and anaerobic threshold (AT; ml VO2/kg/min) from a graded exercise stress test on an electronically braked bicycle ergometer. Anaerobic performance was assessed from the average work of two bouts of pedaling to exhaustion at a load corresponding to 130% Vo2max from graded exercise. Both aerobic and anaerobic performances were decreased in subjects with CF (p < 0.001). The duration of anaerobic exercise in subjects with CF was similar to control subjects. In control subjects, pulmonary function did not correlate to aerobic or anaerobic exercise. In subjects with CF significant relationships between FEV1, vital capacity, and FEF25-75% to AT were found, suggesting the pulmonary limitation to aerobic capacity. In both patients with CF and control subjects, lean body mass and arm muscle area significantly correlated with anaerobic performance but not with VO2max or AT. We conclude that nutritional status, rather than pulmonary function, is the major determinant of anaerobic exercise capacity in CF. The preserved duration of anaerobic exercise at equivalent workloads (corresponding to 130% of VO2max from graded exercise) suggests that readily available energy stores in muscle may be similar in CF and normal individuals.

Authors+Show Affiliations

Division of Pediatric Pulmonology, Childrens Hospital Los Angeles, California 90027, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9563732

Citation

Shah, A R., et al. "Determinants of Aerobic and Anaerobic Exercise Performance in Cystic Fibrosis." American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 4 Pt 1, 1998, pp. 1145-50.
Shah AR, Gozal D, Keens TG. Determinants of aerobic and anaerobic exercise performance in cystic fibrosis. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1145-50.
Shah, A. R., Gozal, D., & Keens, T. G. (1998). Determinants of aerobic and anaerobic exercise performance in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 157(4 Pt 1), pp. 1145-50.
Shah AR, Gozal D, Keens TG. Determinants of Aerobic and Anaerobic Exercise Performance in Cystic Fibrosis. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1145-50. PubMed PMID: 9563732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of aerobic and anaerobic exercise performance in cystic fibrosis. AU - Shah,A R, AU - Gozal,D, AU - Keens,T G, PY - 1998/5/1/pubmed PY - 1998/5/1/medline PY - 1998/5/1/entrez SP - 1145 EP - 50 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 157 IS - 4 Pt 1 N2 - We examined aerobic and anaerobic exercise performance in 17 subjects with cystic fibrosis (CF) (age 25+/-10 [SD] yr; 47% females; FEV1 62+/-21% pred) and 17 age- and sex-matched control subjects (age 25+/-8 [SD] yr; 41% females; FEV1 112+/-15% pred) in relation to pulmonary function and nutritional status. Aerobic capacity was determined as maximal oxygen consumption (VO2max) (ml/kg/min) and anaerobic threshold (AT; ml VO2/kg/min) from a graded exercise stress test on an electronically braked bicycle ergometer. Anaerobic performance was assessed from the average work of two bouts of pedaling to exhaustion at a load corresponding to 130% Vo2max from graded exercise. Both aerobic and anaerobic performances were decreased in subjects with CF (p < 0.001). The duration of anaerobic exercise in subjects with CF was similar to control subjects. In control subjects, pulmonary function did not correlate to aerobic or anaerobic exercise. In subjects with CF significant relationships between FEV1, vital capacity, and FEF25-75% to AT were found, suggesting the pulmonary limitation to aerobic capacity. In both patients with CF and control subjects, lean body mass and arm muscle area significantly correlated with anaerobic performance but not with VO2max or AT. We conclude that nutritional status, rather than pulmonary function, is the major determinant of anaerobic exercise capacity in CF. The preserved duration of anaerobic exercise at equivalent workloads (corresponding to 130% of VO2max from graded exercise) suggests that readily available energy stores in muscle may be similar in CF and normal individuals. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/9563732/Determinants_of_aerobic_and_anaerobic_exercise_performance_in_cystic_fibrosis_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm.157.4.9705023?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -