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Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds.
Clin Infect Dis 1998; 26(4):840-6CI

Abstract

The purpose of this study was to examine the association between experimental rhinovirus infection and the elaboration of interleukin-8 (IL-8) into nasal secretions of volunteers and to determine the effect of pentoxifylline on IL-8 elaboration and rhinovirus-associated common cold symptoms. Fifty-four subjects with experimental rhinovirus infections and 20 sham-inoculated subjects were studied. Pentoxifylline had no effect on rhinovirus-induced symptoms or nasal-secretion IL-8 concentrations. IL-8 concentrations were significantly greater in nasal secretions from infected symptomatic subjects than in those from infected asymptomatic or sham-challenged subjects on days 2-4 after virus challenge. In infected subjects, there was significant rank correlation between nasal obstruction severity, rhinorrhea severity, and nasal-wash albumin concentrations and the change in IL-8 concentration from baseline on days 2-4 after virus challenge.

Authors+Show Affiliations

Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9564459

Citation

Turner, R B., et al. "Association Between Interleukin-8 Concentration in Nasal Secretions and Severity of Symptoms of Experimental Rhinovirus Colds." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 26, no. 4, 1998, pp. 840-6.
Turner RB, Weingand KW, Yeh CH, et al. Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Clin Infect Dis. 1998;26(4):840-6.
Turner, R. B., Weingand, K. W., Yeh, C. H., & Leedy, D. W. (1998). Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 26(4), pp. 840-6.
Turner RB, et al. Association Between Interleukin-8 Concentration in Nasal Secretions and Severity of Symptoms of Experimental Rhinovirus Colds. Clin Infect Dis. 1998;26(4):840-6. PubMed PMID: 9564459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. AU - Turner,R B, AU - Weingand,K W, AU - Yeh,C H, AU - Leedy,D W, PY - 1998/6/13/pubmed PY - 1998/6/13/medline PY - 1998/6/13/entrez SP - 840 EP - 6 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 26 IS - 4 N2 - The purpose of this study was to examine the association between experimental rhinovirus infection and the elaboration of interleukin-8 (IL-8) into nasal secretions of volunteers and to determine the effect of pentoxifylline on IL-8 elaboration and rhinovirus-associated common cold symptoms. Fifty-four subjects with experimental rhinovirus infections and 20 sham-inoculated subjects were studied. Pentoxifylline had no effect on rhinovirus-induced symptoms or nasal-secretion IL-8 concentrations. IL-8 concentrations were significantly greater in nasal secretions from infected symptomatic subjects than in those from infected asymptomatic or sham-challenged subjects on days 2-4 after virus challenge. In infected subjects, there was significant rank correlation between nasal obstruction severity, rhinorrhea severity, and nasal-wash albumin concentrations and the change in IL-8 concentration from baseline on days 2-4 after virus challenge. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/9564459/Association_between_interleukin_8_concentration_in_nasal_secretions_and_severity_of_symptoms_of_experimental_rhinovirus_colds_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/513922 DB - PRIME DP - Unbound Medicine ER -