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The relationship of ocular factors to the incidence and progression of age-related maculopathy.
Arch Ophthalmol. 1998 Apr; 116(4):506-13.AO

Abstract

OBJECTIVE

To examine the association between ocular factors and the incidence and progression of age-related maculopathy.

PARTICIPANTS

A population of 3684 adults (43-86 years of age at baseline) living in Beaver Dam, Wis, studied at baseline and 5 years later.

METHODS

Standardized protocols for refraction and determination of iris color, administration of a questionnaire, and slitlamp and retroillumination photographs of the lenses to determine cataract type and stereoscopic color fundus photographs to determine presence and severity of age-related maculopathy. Standard univariate and multivariate analyses were performed.

MAIN OUTCOME MEASURES

Incidence and progression of age-related maculopathy.

RESULTS

After controlling for age, eyes that had undergone cataract surgery before baseline were more likely to have progression of age-related maculopathy (odds ratio, 2.71; 95% confidence interval [CI], 1.69-4.35) and to develop signs of late age-related maculopathy (odds ratio, 2.80; 95% CI, 1.03-7.63) than were eyes that were phakic at baseline. These relationships remained after controlling for other risk factors in multivariate analyses. There was no relationship of nuclear cataract, cortical cataract, or iris color to the incidence and progression of age-related maculopathy.

CONCLUSION

These findings indicate a relationship between cataract surgery and increased risk of progression of age-related maculopathy.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705-2397, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9565051

Citation

Klein, R, et al. "The Relationship of Ocular Factors to the Incidence and Progression of Age-related Maculopathy." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 116, no. 4, 1998, pp. 506-13.
Klein R, Klein BE, Jensen SC, et al. The relationship of ocular factors to the incidence and progression of age-related maculopathy. Arch Ophthalmol. 1998;116(4):506-13.
Klein, R., Klein, B. E., Jensen, S. C., & Cruickshanks, K. J. (1998). The relationship of ocular factors to the incidence and progression of age-related maculopathy. Archives of Ophthalmology (Chicago, Ill. : 1960), 116(4), 506-13.
Klein R, et al. The Relationship of Ocular Factors to the Incidence and Progression of Age-related Maculopathy. Arch Ophthalmol. 1998;116(4):506-13. PubMed PMID: 9565051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of ocular factors to the incidence and progression of age-related maculopathy. AU - Klein,R, AU - Klein,B E, AU - Jensen,S C, AU - Cruickshanks,K J, PY - 1998/5/2/pubmed PY - 1998/5/2/medline PY - 1998/5/2/entrez SP - 506 EP - 13 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch Ophthalmol VL - 116 IS - 4 N2 - OBJECTIVE: To examine the association between ocular factors and the incidence and progression of age-related maculopathy. PARTICIPANTS: A population of 3684 adults (43-86 years of age at baseline) living in Beaver Dam, Wis, studied at baseline and 5 years later. METHODS: Standardized protocols for refraction and determination of iris color, administration of a questionnaire, and slitlamp and retroillumination photographs of the lenses to determine cataract type and stereoscopic color fundus photographs to determine presence and severity of age-related maculopathy. Standard univariate and multivariate analyses were performed. MAIN OUTCOME MEASURES: Incidence and progression of age-related maculopathy. RESULTS: After controlling for age, eyes that had undergone cataract surgery before baseline were more likely to have progression of age-related maculopathy (odds ratio, 2.71; 95% confidence interval [CI], 1.69-4.35) and to develop signs of late age-related maculopathy (odds ratio, 2.80; 95% CI, 1.03-7.63) than were eyes that were phakic at baseline. These relationships remained after controlling for other risk factors in multivariate analyses. There was no relationship of nuclear cataract, cortical cataract, or iris color to the incidence and progression of age-related maculopathy. CONCLUSION: These findings indicate a relationship between cataract surgery and increased risk of progression of age-related maculopathy. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/9565051/The_relationship_of_ocular_factors_to_the_incidence_and_progression_of_age_related_maculopathy_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/116/pg/506 DB - PRIME DP - Unbound Medicine ER -