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Hepatorenal syndrome.
Forum (Genova). 1998 Jan-Mar; 8(1):62-81.F

Abstract

The hepatorenal syndrome is a severe and common complication of patients with advanced cirrhosis and ascites. It is characterised not only by renal failure but also by marked alterations in systemic haemodynamics. Renal failure is due to a marked hypoperfusion of the kidney secondary to renal vasoconstriction. Although the pathogenesis of hepatorenal syndrome is not completely understood, it is thought to be the extreme manifestation of the underfilling of the arterial circulation secondary to an arterial vasodilation, located mainly in the splanchnic circulation. Recently, a revised definition and diagnostic criteria of hepatorenal syndrome have been proposed. The prognosis of patients with hepatorenal syndrome is very poor. Liver transplantation is the only effective treatment but it is not applicable in most cases due to short survival. New therapies developed during the last years, such as the use of systemic vasoconstrictors or transjugular intra-hepatic portosystemic shunts appear to be promising, but prospective investigations are needed to delineate their real usefulness.

Authors+Show Affiliations

Bataller R
Liver Unit, Institute Clinic of Digestive Diseases, University of Barcelona, Barcelona, Spain.
Arroyo V
No affiliation info available
Ginès P
No affiliation info available
Sort P
No affiliation info available

MeSH

AscitesHemodynamicsHepatorenal SyndromeHumansKidneyKidney Failure, ChronicLiver CirrhosisLiver TransplantationPortasystemic Shunt, Transjugular IntrahepaticPrognosisProspective StudiesRenal CirculationSplanchnic CirculationSurvival RateVasoconstrictionVasoconstrictor AgentsVasodilation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9565447

Citation

Bataller, R, et al. "Hepatorenal Syndrome." Forum (Genoa, Italy), vol. 8, no. 1, 1998, pp. 62-81.
Bataller R, Arroyo V, Ginès P, et al. Hepatorenal syndrome. Forum (Genova). 1998;8(1):62-81.
Bataller, R., Arroyo, V., Ginès, P., & Sort, P. (1998). Hepatorenal syndrome. Forum (Genoa, Italy), 8(1), 62-81.
Bataller R, et al. Hepatorenal Syndrome. Forum (Genova). 1998 Jan-Mar;8(1):62-81. PubMed PMID: 9565447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatorenal syndrome. AU - Bataller,R, AU - Arroyo,V, AU - Ginès,P, AU - Sort,P, PY - 1998/6/17/pubmed PY - 1998/6/17/medline PY - 1998/6/17/entrez SP - 62 EP - 81 JF - Forum (Genoa, Italy) JO - Forum (Genova) VL - 8 IS - 1 N2 - The hepatorenal syndrome is a severe and common complication of patients with advanced cirrhosis and ascites. It is characterised not only by renal failure but also by marked alterations in systemic haemodynamics. Renal failure is due to a marked hypoperfusion of the kidney secondary to renal vasoconstriction. Although the pathogenesis of hepatorenal syndrome is not completely understood, it is thought to be the extreme manifestation of the underfilling of the arterial circulation secondary to an arterial vasodilation, located mainly in the splanchnic circulation. Recently, a revised definition and diagnostic criteria of hepatorenal syndrome have been proposed. The prognosis of patients with hepatorenal syndrome is very poor. Liver transplantation is the only effective treatment but it is not applicable in most cases due to short survival. New therapies developed during the last years, such as the use of systemic vasoconstrictors or transjugular intra-hepatic portosystemic shunts appear to be promising, but prospective investigations are needed to delineate their real usefulness. SN - 1121-8142 UR - https://www.unboundmedicine.com/medline/citation/9565447/Hepatorenal_syndrome_ L2 - http://www.diseaseinfosearch.org/result/3341 DB - PRIME DP - Unbound Medicine ER -