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The effects of low doses of ranitidine on intragastric acidity in healthy men.
Aliment Pharmacol Ther. 1998 Mar; 12(3):255-61.AP

Abstract

BACKGROUND

H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity.

AIM

To determine the effects of single low doses of ranitidine on intragastric acidity.

METHODS

Intragastric pH was measured for 9 h after lunch in five studies involving 24 healthy male volunteers. Antacid was given to all subjects on day 1. They then received single oral doses of a study drug 45 min after lunch on four separate occasions: placebo and either ranitidine 25 mg, 75 mg or 125 mg were given double-blind according to a predetermined randomization schedule.

RESULTS

During both of the post-dosing time periods (0-5 h and 5-9 h) there were significant decreases in integrated intragastric acidity for each ranitidine dose compared with placebo (P < 0.0001). There was a significant linear relationship between dose and integrated intragastric acidity with a greater decrease in acidity with increasing ranitidine doses (P < 0.0001). Compared with placebo, time with pH > 3 was significantly greater for ranitidine 75 mg and 125 mg (P < 0.001), but not ranitidine 25 mg. Results with the antacid were similar to placebo.

CONCLUSIONS

Using low doses of ranitidine (25, 75 or 125 mg) there was a dose-related decrease in intragastric acidity for 9 h after dosing. A single dose of antacid did not decrease intragastric acidity significantly.

Authors+Show Affiliations

Royal Free Hospital School of Medicine, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9570260

Citation

Wyeth, J W., et al. "The Effects of Low Doses of Ranitidine On Intragastric Acidity in Healthy Men." Alimentary Pharmacology & Therapeutics, vol. 12, no. 3, 1998, pp. 255-61.
Wyeth JW, Pounder RE, Sercombe JC, et al. The effects of low doses of ranitidine on intragastric acidity in healthy men. Aliment Pharmacol Ther. 1998;12(3):255-61.
Wyeth, J. W., Pounder, R. E., Sercombe, J. C., & Snell, C. C. (1998). The effects of low doses of ranitidine on intragastric acidity in healthy men. Alimentary Pharmacology & Therapeutics, 12(3), 255-61.
Wyeth JW, et al. The Effects of Low Doses of Ranitidine On Intragastric Acidity in Healthy Men. Aliment Pharmacol Ther. 1998;12(3):255-61. PubMed PMID: 9570260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of low doses of ranitidine on intragastric acidity in healthy men. AU - Wyeth,J W, AU - Pounder,R E, AU - Sercombe,J C, AU - Snell,C C, PY - 1998/5/7/pubmed PY - 1998/5/7/medline PY - 1998/5/7/entrez SP - 255 EP - 61 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 12 IS - 3 N2 - BACKGROUND: H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. AIM: To determine the effects of single low doses of ranitidine on intragastric acidity. METHODS: Intragastric pH was measured for 9 h after lunch in five studies involving 24 healthy male volunteers. Antacid was given to all subjects on day 1. They then received single oral doses of a study drug 45 min after lunch on four separate occasions: placebo and either ranitidine 25 mg, 75 mg or 125 mg were given double-blind according to a predetermined randomization schedule. RESULTS: During both of the post-dosing time periods (0-5 h and 5-9 h) there were significant decreases in integrated intragastric acidity for each ranitidine dose compared with placebo (P < 0.0001). There was a significant linear relationship between dose and integrated intragastric acidity with a greater decrease in acidity with increasing ranitidine doses (P < 0.0001). Compared with placebo, time with pH > 3 was significantly greater for ranitidine 75 mg and 125 mg (P < 0.001), but not ranitidine 25 mg. Results with the antacid were similar to placebo. CONCLUSIONS: Using low doses of ranitidine (25, 75 or 125 mg) there was a dose-related decrease in intragastric acidity for 9 h after dosing. A single dose of antacid did not decrease intragastric acidity significantly. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/9570260/The_effects_of_low_doses_of_ranitidine_on_intragastric_acidity_in_healthy_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1998&amp;volume=12&amp;issue=3&amp;spage=255 DB - PRIME DP - Unbound Medicine ER -