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MDMA elicits behavioral and neurochemical sensitization in rats.
Neuropsychopharmacology. 1998 Jun; 18(6):469-79.N

Abstract

Rats were treated with repeated injections of saline or one of two doses of (+/-)3,4-methylenedioxymethamphetamine (MDMA; 5 or 20 mg/kg, s.c.). Rats pretreated with either of the two repeated MDMA treatment regimens demonstrated an augmented increase in motor activity to an injection of MDMA made 12 days after the last repeated injection compared with either the first MDMA injection or MDMA given to animals pretreated with repeated saline. Furthermore, animals pretreated with the highest dose of repeated MDMA revealed a greater behavioral response to cocaine (15 mg/kg, i.p.). Microdialysis was conducted in the nucleus accumbens and the capacity of MDMA (5 mg/kg, s.c.) to elevate extracellular dopamine content was augmented in rats pretreated with repeated MDMA compared with the animals pretreated with repeated saline. These data reveal repeated MDMA administration produces behavioral sensitization and enhanced dopamine transmission in the nucleus accumbens of rats.

Authors+Show Affiliations

Alcohol and Drug Abuse Program, Washington State University, Pullman 99164-6520, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9571655

Citation

Kalivas, P W., et al. "MDMA Elicits Behavioral and Neurochemical Sensitization in Rats." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 18, no. 6, 1998, pp. 469-79.
Kalivas PW, Duffy P, White SR. MDMA elicits behavioral and neurochemical sensitization in rats. Neuropsychopharmacology. 1998;18(6):469-79.
Kalivas, P. W., Duffy, P., & White, S. R. (1998). MDMA elicits behavioral and neurochemical sensitization in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 18(6), 469-79.
Kalivas PW, Duffy P, White SR. MDMA Elicits Behavioral and Neurochemical Sensitization in Rats. Neuropsychopharmacology. 1998;18(6):469-79. PubMed PMID: 9571655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDMA elicits behavioral and neurochemical sensitization in rats. AU - Kalivas,P W, AU - Duffy,P, AU - White,S R, PY - 1998/5/8/pubmed PY - 1998/5/8/medline PY - 1998/5/8/entrez SP - 469 EP - 79 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 18 IS - 6 N2 - Rats were treated with repeated injections of saline or one of two doses of (+/-)3,4-methylenedioxymethamphetamine (MDMA; 5 or 20 mg/kg, s.c.). Rats pretreated with either of the two repeated MDMA treatment regimens demonstrated an augmented increase in motor activity to an injection of MDMA made 12 days after the last repeated injection compared with either the first MDMA injection or MDMA given to animals pretreated with repeated saline. Furthermore, animals pretreated with the highest dose of repeated MDMA revealed a greater behavioral response to cocaine (15 mg/kg, i.p.). Microdialysis was conducted in the nucleus accumbens and the capacity of MDMA (5 mg/kg, s.c.) to elevate extracellular dopamine content was augmented in rats pretreated with repeated MDMA compared with the animals pretreated with repeated saline. These data reveal repeated MDMA administration produces behavioral sensitization and enhanced dopamine transmission in the nucleus accumbens of rats. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/9571655/MDMA_elicits_behavioral_and_neurochemical_sensitization_in_rats_ L2 - http://dx.doi.org/10.1016/S0893-133X(97)00195-4 DB - PRIME DP - Unbound Medicine ER -