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Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.
Biosci Biotechnol Biochem. 1998 Mar; 62(3):434-7.BB

Abstract

Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells.

Authors+Show Affiliations

Division of Science of Biological Resources, Graduate School of Science and Technology, Kobe University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9571772

Citation

Mizuno, M, et al. "Polysaccharides From Agaricus Blazei Stimulate Lymphocyte T-cell Subsets in Mice." Bioscience, Biotechnology, and Biochemistry, vol. 62, no. 3, 1998, pp. 434-7.
Mizuno M, Morimoto M, Minato K, et al. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem. 1998;62(3):434-7.
Mizuno, M., Morimoto, M., Minato, K., & Tsuchida, H. (1998). Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Bioscience, Biotechnology, and Biochemistry, 62(3), 434-7.
Mizuno M, et al. Polysaccharides From Agaricus Blazei Stimulate Lymphocyte T-cell Subsets in Mice. Biosci Biotechnol Biochem. 1998;62(3):434-7. PubMed PMID: 9571772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. AU - Mizuno,M, AU - Morimoto,M, AU - Minato,K, AU - Tsuchida,H, PY - 1998/5/8/pubmed PY - 1998/5/8/medline PY - 1998/5/8/entrez SP - 434 EP - 7 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 62 IS - 3 N2 - Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/9571772/Polysaccharides_from_Agaricus_blazei_stimulate_lymphocyte_T_cell_subsets_in_mice_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/62.434?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -