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Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.
Biosci Biotechnol Biochem. 1998 Mar; 62(3):434-7.BB

Abstract

Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells.

Links

Publisher Full Text
joi.jlc.jst.go.jp
tandfonline.com

Authors+Show Affiliations

Mizuno M
Division of Science of Biological Resources, Graduate School of Science and Technology, Kobe University, Japan.
Morimoto M
No affiliation info available
Minato K
No affiliation info available
Tsuchida H
No affiliation info available

MeSH

Adjuvants, ImmunologicAgaricusAnimalsCarbon IsotopesFemaleFlow CytometryLymphocyte ActivationMiceMice, Inbred C3HNuclear Magnetic Resonance, BiomolecularPolysaccharidesSpleenStimulation, ChemicalT-Lymphocyte SubsetsT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9571772

Citation

Mizuno, M, et al. "Polysaccharides From Agaricus Blazei Stimulate Lymphocyte T-cell Subsets in Mice." Bioscience, Biotechnology, and Biochemistry, vol. 62, no. 3, 1998, pp. 434-7.
Mizuno M, Morimoto M, Minato K, et al. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem. 1998;62(3):434-7.
Mizuno, M., Morimoto, M., Minato, K., & Tsuchida, H. (1998). Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Bioscience, Biotechnology, and Biochemistry, 62(3), 434-7.
Mizuno M, et al. Polysaccharides From Agaricus Blazei Stimulate Lymphocyte T-cell Subsets in Mice. Biosci Biotechnol Biochem. 1998;62(3):434-7. PubMed PMID: 9571772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. AU - Mizuno,M, AU - Morimoto,M, AU - Minato,K, AU - Tsuchida,H, PY - 1998/5/8/pubmed PY - 1998/5/8/medline PY - 1998/5/8/entrez SP - 434 EP - 7 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 62 IS - 3 N2 - Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/9571772/Polysaccharides_from_Agaricus_blazei_stimulate_lymphocyte_T_cell_subsets_in_mice_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/62.434?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -