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Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L.
Lloydia. 1976 Jul-Aug; 39(4):223-4.L

Abstract

A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the isolation of aloe emodin (1). This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A note-worthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

957911

Citation

Kupchan, S M., and A Karim. "Tumor Inhibitors. 114. Aloe Emodin: Antileukemic Principle Isolated From Rhamnus Frangula L." Lloydia, vol. 39, no. 4, 1976, pp. 223-4.
Kupchan SM, Karim A. Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L. Lloydia. 1976;39(4):223-4.
Kupchan, S. M., & Karim, A. (1976). Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L. Lloydia, 39(4), 223-4.
Kupchan SM, Karim A. Tumor Inhibitors. 114. Aloe Emodin: Antileukemic Principle Isolated From Rhamnus Frangula L. Lloydia. 1976 Jul-Aug;39(4):223-4. PubMed PMID: 957911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L. AU - Kupchan,S M, AU - Karim,A, PY - 1976/7/1/pubmed PY - 1976/7/1/medline PY - 1976/7/1/entrez SP - 223 EP - 4 JF - Lloydia JO - Lloydia VL - 39 IS - 4 N2 - A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the isolation of aloe emodin (1). This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A note-worthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended. SN - 0024-5461 UR - https://www.unboundmedicine.com/medline/citation/957911/Tumor_inhibitors__114__Aloe_emodin:_antileukemic_principle_isolated_from_Rhamnus_frangula_L_ L2 - https://medlineplus.gov/chroniclymphocyticleukemia.html DB - PRIME DP - Unbound Medicine ER -