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Evaluation of an extensively hydrolyzed casein-whey protein formula in immediate cow's milk protein hypersensitivity.

Abstract

BACKGROUND

Hydrolysate formulas are safe for most infants who are allergic to cow's milk. The purpose of this study was to assess the clinical tolerance and safety of an extensively hydrolyzed casein-whey protein formula in a homogeneous group of patients with immediate cow's milk hypersensitivity.

METHODS

The study population consisted of 33 infants in whom immediate cow's milk protein allergy had been diagnosed by clinical data, evidence of specific immunoglobulin E antibodies, and positive results in a controlled challenge test with cow's milk proteins.

RESULTS

The hydrolysate was well tolerated in 31 of the 33 patients, which represented a 94% effectiveness. Using 95% confidence intervals generated for a binomial outcome (reaction-no reaction), the casein-whey protein formula is tolerated by 84.4% to 99% of infants with immediate immunoglobulinE-mediated cow's milk protein allergy. These figures are in the range of values recommended for this type of product.

CONCLUSIONS

This extensively hydrolyzed casein-whey protein formula is generally safe to feed children with immediate hypersensitivity to cow's milk. However. it is advisable that the first intakes be given under direct medical supervision, in that the occurrence of adverse reactions in highly sensitive infants cannot be unequivocally excluded.

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  • Authors+Show Affiliations

    ,

    Allergy Service, Hospital Infantil Universitario La Paz, Madrid, Spain.

    , , , ,

    Source

    MeSH

    Caseins
    Humans
    Hydrolysis
    Immunoglobulin E
    Infant
    Infant Food
    Milk Hypersensitivity
    Milk Proteins
    Skin Tests
    Whey Proteins

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9580376

    Citation

    Martín-Esteban, M, et al. "Evaluation of an Extensively Hydrolyzed Casein-whey Protein Formula in Immediate Cow's Milk Protein Hypersensitivity." Journal of Pediatric Gastroenterology and Nutrition, vol. 26, no. 4, 1998, pp. 398-401.
    Martín-Esteban M, García-Ara MC, Banqué-Molas M, et al. Evaluation of an extensively hydrolyzed casein-whey protein formula in immediate cow's milk protein hypersensitivity. J Pediatr Gastroenterol Nutr. 1998;26(4):398-401.
    Martín-Esteban, M., García-Ara, M. C., Banqué-Molas, M., Boyano-Martínez, M. T., Martín-Muñoz, F., & Díaz-Pena, J. M. (1998). Evaluation of an extensively hydrolyzed casein-whey protein formula in immediate cow's milk protein hypersensitivity. Journal of Pediatric Gastroenterology and Nutrition, 26(4), pp. 398-401.
    Martín-Esteban M, et al. Evaluation of an Extensively Hydrolyzed Casein-whey Protein Formula in Immediate Cow's Milk Protein Hypersensitivity. J Pediatr Gastroenterol Nutr. 1998;26(4):398-401. PubMed PMID: 9580376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of an extensively hydrolyzed casein-whey protein formula in immediate cow's milk protein hypersensitivity. AU - Martín-Esteban,M, AU - García-Ara,M C, AU - Banqué-Molas,M, AU - Boyano-Martínez,M T, AU - Martín-Muñoz,F, AU - Díaz-Pena,J M, PY - 1998/5/15/pubmed PY - 1998/5/15/medline PY - 1998/5/15/entrez SP - 398 EP - 401 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 26 IS - 4 N2 - BACKGROUND: Hydrolysate formulas are safe for most infants who are allergic to cow's milk. The purpose of this study was to assess the clinical tolerance and safety of an extensively hydrolyzed casein-whey protein formula in a homogeneous group of patients with immediate cow's milk hypersensitivity. METHODS: The study population consisted of 33 infants in whom immediate cow's milk protein allergy had been diagnosed by clinical data, evidence of specific immunoglobulin E antibodies, and positive results in a controlled challenge test with cow's milk proteins. RESULTS: The hydrolysate was well tolerated in 31 of the 33 patients, which represented a 94% effectiveness. Using 95% confidence intervals generated for a binomial outcome (reaction-no reaction), the casein-whey protein formula is tolerated by 84.4% to 99% of infants with immediate immunoglobulinE-mediated cow's milk protein allergy. These figures are in the range of values recommended for this type of product. CONCLUSIONS: This extensively hydrolyzed casein-whey protein formula is generally safe to feed children with immediate hypersensitivity to cow's milk. However. it is advisable that the first intakes be given under direct medical supervision, in that the occurrence of adverse reactions in highly sensitive infants cannot be unequivocally excluded. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/9580376/Evaluation_of_an_extensively_hydrolyzed_casein_whey_protein_formula_in_immediate_cow's_milk_protein_hypersensitivity_ L2 - http://Insights.ovid.com/pubmed?pmid=9580376 DB - PRIME DP - Unbound Medicine ER -