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[Neonatal morbidity associated with meconial amniotic fluid].
An Esp Pediatr. 1998 Jan; 48(1):54-9.AE

Abstract

BACKGROUND

The significance of meconium-stained amniotic fluid (MSAF) is discussed, both in regards to obstetric and pediatric management. The primary concerns regarding MSAF have been its significance as a sign of fetal distress/perinatal asphyxia and the prevention of associated morbidity such as meconium aspiration syndrome. The objectives of our study were: (1) To know the incidence and type of MSAF, (2) to study the associated morbidity in newborns with MSAF admitted to the Neonatal Care Unit (NCU), and (3) to analyze the perinatal differences between newborns with moderate versus thick MSAF.

PATIENTS AND METHODS

A retrospective study was performed to know the incidence of MSAF in all of the deliveries in our hospital during a 4 year period. The consistency of meconium was classified into 3 classes, thin (light), moderate or thick (heavy). On the other hand, a prospective analysis was undertaken to determine the morbidity of all meconium-stained neonates admitted to our NCU during this period, mainly in relation to perinatal asphyxia, pulmonary, gastrointestinal and infectious pathology and neonatal mortality.

RESULTS

The presence of MASF complicates 18% of all of our deliveries with it being mild in 10.8%, moderate in 4.4% and severe in 2.8%. Of all newborns with MSAF, one third were admitted to the NCU, mainly for two reasons, association with perinatal asphyxia (124 cases) and observation of a risk of meconium aspiration syndrome (85 cases). The main neonatal morbidities associated with MSAF in our populations were perinatal asphyxia in 56.1% (32 cases of severe perinatal asphyxia and 92 non-severe), pulmonary pathology in 34% (meconium aspiration syndrome in 32 cases and other respiratory abnormalities in 43) and gastrointestinal pathology in 30.5% (transitory feeding intolerance in all cases). Four cases of meconium-stained neonates were exitus. The neonatal morbidity is significantly more frequent in relation to thick meconium and also if perinatal asphyxia is associated to MSAF.

CONCLUSIONS

Although the relationship between MSAF and perinatal asphyxia is controversial, their association increases neonatal morbidity. In accordance with our results, thick meconium is implicated as a risk factor influencing the well being during the intrapartum and postpartum periods.

Authors+Show Affiliations

González de Dios J
Departamento de Pediatría, Hospital Universitario San Juan, Alicante.
Moya Benavent M
No affiliation info available
Barbal Rodoreda A
No affiliation info available
Dura Trave T
No affiliation info available
Juste Ruiz M
No affiliation info available
Castaño Iglesias C
No affiliation info available
González Montero R
No affiliation info available

MeSH

Birth WeightChi-Square DistributionFemaleGestational AgeHumansIncidenceInfant, NewbornMaleMeconiumMeconium Aspiration SyndromeProspective StudiesRetrospective StudiesSpainStatistics, NonparametricViscosity

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

9580399

Citation

González de Dios, J, et al. "[Neonatal Morbidity Associated With Meconial Amniotic Fluid]." Anales Espanoles De Pediatria, vol. 48, no. 1, 1998, pp. 54-9.
González de Dios J, Moya Benavent M, Barbal Rodoreda A, et al. [Neonatal morbidity associated with meconial amniotic fluid]. An Esp Pediatr. 1998;48(1):54-9.
González de Dios, J., Moya Benavent, M., Barbal Rodoreda, A., Dura Trave, T., Juste Ruiz, M., Castaño Iglesias, C., & González Montero, R. (1998). [Neonatal morbidity associated with meconial amniotic fluid]. Anales Espanoles De Pediatria, 48(1), 54-9.
González de Dios J, et al. [Neonatal Morbidity Associated With Meconial Amniotic Fluid]. An Esp Pediatr. 1998;48(1):54-9. PubMed PMID: 9580399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neonatal morbidity associated with meconial amniotic fluid]. AU - González de Dios,J, AU - Moya Benavent,M, AU - Barbal Rodoreda,A, AU - Dura Trave,T, AU - Juste Ruiz,M, AU - Castaño Iglesias,C, AU - González Montero,R, PY - 1998/5/15/pubmed PY - 1998/5/15/medline PY - 1998/5/15/entrez SP - 54 EP - 9 JF - Anales espanoles de pediatria JO - An Esp Pediatr VL - 48 IS - 1 N2 - BACKGROUND: The significance of meconium-stained amniotic fluid (MSAF) is discussed, both in regards to obstetric and pediatric management. The primary concerns regarding MSAF have been its significance as a sign of fetal distress/perinatal asphyxia and the prevention of associated morbidity such as meconium aspiration syndrome. The objectives of our study were: (1) To know the incidence and type of MSAF, (2) to study the associated morbidity in newborns with MSAF admitted to the Neonatal Care Unit (NCU), and (3) to analyze the perinatal differences between newborns with moderate versus thick MSAF. PATIENTS AND METHODS: A retrospective study was performed to know the incidence of MSAF in all of the deliveries in our hospital during a 4 year period. The consistency of meconium was classified into 3 classes, thin (light), moderate or thick (heavy). On the other hand, a prospective analysis was undertaken to determine the morbidity of all meconium-stained neonates admitted to our NCU during this period, mainly in relation to perinatal asphyxia, pulmonary, gastrointestinal and infectious pathology and neonatal mortality. RESULTS: The presence of MASF complicates 18% of all of our deliveries with it being mild in 10.8%, moderate in 4.4% and severe in 2.8%. Of all newborns with MSAF, one third were admitted to the NCU, mainly for two reasons, association with perinatal asphyxia (124 cases) and observation of a risk of meconium aspiration syndrome (85 cases). The main neonatal morbidities associated with MSAF in our populations were perinatal asphyxia in 56.1% (32 cases of severe perinatal asphyxia and 92 non-severe), pulmonary pathology in 34% (meconium aspiration syndrome in 32 cases and other respiratory abnormalities in 43) and gastrointestinal pathology in 30.5% (transitory feeding intolerance in all cases). Four cases of meconium-stained neonates were exitus. The neonatal morbidity is significantly more frequent in relation to thick meconium and also if perinatal asphyxia is associated to MSAF. CONCLUSIONS: Although the relationship between MSAF and perinatal asphyxia is controversial, their association increases neonatal morbidity. In accordance with our results, thick meconium is implicated as a risk factor influencing the well being during the intrapartum and postpartum periods. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/9580399/[Neonatal_morbidity_associated_with_meconial_amniotic_fluid]_ DB - PRIME DP - Unbound Medicine ER -