Tags

Type your tag names separated by a space and hit enter

Inhibition of establishment and growth of mouse liver metastases after treatment with interferon gamma and beta-1,3-D-glucan.
Hepatology. 1998 May; 27(5):1241-8.Hep

Abstract

The purpose of this study was to investigate the combined antitumor effect of aminated beta-1,3-D-glucan (AG) and interferon-gamma (IFN-gamma) in an experimental liver metastasis model. Liver metastases were established by inoculation of C-26 colon carcinoma cells into the superior mesenteric vein of syngeneic mice. Treatment of mice started 24 hours after inoculation of tumor cells by daily intravenous injections of either AG, IFN-gamma, or a combination of both for a duration of 6 days. The resultant liver metastases were then quantified after an additional period of 11 days. Combination of IFN-gamma and AG inhibited the growth of liver metastases almost entirely. IFN-gamma was also very efficient, while AG alone did not exert any significant antitumor effect. These results, along with histological studies from mice receiving AG and IFN-gamma, indicated that activation and recruitment of liver macrophages may be a part of the mechanism responsible for the inhibition of metastatic growth observed in this study.

Links

Publisher Full Text

Authors+Show Affiliations

Sveinbjørnsson B
Department of Experimental Pathology, Institute of Medical Biology, University of Tromsø, Norway.
Rushfeldt C
No affiliation info available
Seljelid R
No affiliation info available
Smedsrød B
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsCarcinomaColonic NeoplasmsDrug SynergismFemaleGlucansInterferon-gammaLiver NeoplasmsMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasm MetastasisRecombinant Proteinsbeta-Glucans

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9581677

Citation

Sveinbjørnsson, B, et al. "Inhibition of Establishment and Growth of Mouse Liver Metastases After Treatment With Interferon Gamma and Beta-1,3-D-glucan." Hepatology (Baltimore, Md.), vol. 27, no. 5, 1998, pp. 1241-8.
Sveinbjørnsson B, Rushfeldt C, Seljelid R, et al. Inhibition of establishment and growth of mouse liver metastases after treatment with interferon gamma and beta-1,3-D-glucan. Hepatology. 1998;27(5):1241-8.
Sveinbjørnsson, B., Rushfeldt, C., Seljelid, R., & Smedsrød, B. (1998). Inhibition of establishment and growth of mouse liver metastases after treatment with interferon gamma and beta-1,3-D-glucan. Hepatology (Baltimore, Md.), 27(5), 1241-8.
Sveinbjørnsson B, et al. Inhibition of Establishment and Growth of Mouse Liver Metastases After Treatment With Interferon Gamma and Beta-1,3-D-glucan. Hepatology. 1998;27(5):1241-8. PubMed PMID: 9581677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of establishment and growth of mouse liver metastases after treatment with interferon gamma and beta-1,3-D-glucan. AU - Sveinbjørnsson,B, AU - Rushfeldt,C, AU - Seljelid,R, AU - Smedsrød,B, PY - 1998/5/15/pubmed PY - 1998/5/15/medline PY - 1998/5/15/entrez SP - 1241 EP - 8 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 27 IS - 5 N2 - The purpose of this study was to investigate the combined antitumor effect of aminated beta-1,3-D-glucan (AG) and interferon-gamma (IFN-gamma) in an experimental liver metastasis model. Liver metastases were established by inoculation of C-26 colon carcinoma cells into the superior mesenteric vein of syngeneic mice. Treatment of mice started 24 hours after inoculation of tumor cells by daily intravenous injections of either AG, IFN-gamma, or a combination of both for a duration of 6 days. The resultant liver metastases were then quantified after an additional period of 11 days. Combination of IFN-gamma and AG inhibited the growth of liver metastases almost entirely. IFN-gamma was also very efficient, while AG alone did not exert any significant antitumor effect. These results, along with histological studies from mice receiving AG and IFN-gamma, indicated that activation and recruitment of liver macrophages may be a part of the mechanism responsible for the inhibition of metastatic growth observed in this study. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/9581677/Inhibition_of_establishment_and_growth_of_mouse_liver_metastases_after_treatment_with_interferon_gamma_and_beta_13_D_glucan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913998001840 DB - PRIME DP - Unbound Medicine ER -