Tags

Type your tag names separated by a space and hit enter

Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission.

Abstract

Malnutrition is observed frequently and is an important complication in patients with Crohn disease (CD). The pathophysiology of malnutrition in this disorder is complex. To obtain a comprehensive picture of nutritional status in patients with long-standing CD that was clinically in remission, we assessed four measures of nutritional status in 32 patients (18 women and 14 men) and 32 matched healthy control subjects: 1) body composition, 2) dietary intake, 3) biochemical indexes of nutrition, and 4) and muscle strength (as a functional index). Mean daily intakes of fiber and phosphorus were significantly lower in CD patients than in control subjects. Serum concentrations of several nutrients (beta-carotene, vitamin C, vitamin E, selenium, and zinc) and activity of the enzyme glutathione peroxidase were also significantly lower in CD patients, as were antioxidant status and serum concentrations of magnesium and vitamin D. Percentage body fat and hamstring muscle strength were significantly lower in male CD patients than in control subjects, whereas muscle strength of the quadriceps was preserved. In conclusion, this study showed a variety of nutritional and functional deficiencies in patients with long-standing CD in remission, especially in male patients with a high lifetime prednisone dose. A comprehensive nutritional assessment seems superior to the assessment of a single dimension of nutritional status.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Gastroenterology, University Hospital Maastricht, The Netherlands. bgee@sint.azm.nl

    , ,

    Source

    MeSH

    Adult
    Biomarkers
    Body Composition
    Case-Control Studies
    Crohn Disease
    Data Interpretation, Statistical
    Diet
    Energy Intake
    Female
    Humans
    Male
    Middle Aged
    Muscle, Skeletal
    Nutrition Disorders
    Nutritional Status
    Physical Endurance
    Remission Induction
    Time Factors
    Vitamin A
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9583850

    Citation

    Geerling, B J., et al. "Comprehensive Nutritional Status in Patients With Long-standing Crohn Disease Currently in Remission." The American Journal of Clinical Nutrition, vol. 67, no. 5, 1998, pp. 919-26.
    Geerling BJ, Badart-Smook A, Stockbrügger RW, et al. Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. Am J Clin Nutr. 1998;67(5):919-26.
    Geerling, B. J., Badart-Smook, A., Stockbrügger, R. W., & Brummer, R. J. (1998). Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. The American Journal of Clinical Nutrition, 67(5), pp. 919-26.
    Geerling BJ, et al. Comprehensive Nutritional Status in Patients With Long-standing Crohn Disease Currently in Remission. Am J Clin Nutr. 1998;67(5):919-26. PubMed PMID: 9583850.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. AU - Geerling,B J, AU - Badart-Smook,A, AU - Stockbrügger,R W, AU - Brummer,R J, PY - 1998/5/16/pubmed PY - 1998/5/16/medline PY - 1998/5/16/entrez SP - 919 EP - 26 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 67 IS - 5 N2 - Malnutrition is observed frequently and is an important complication in patients with Crohn disease (CD). The pathophysiology of malnutrition in this disorder is complex. To obtain a comprehensive picture of nutritional status in patients with long-standing CD that was clinically in remission, we assessed four measures of nutritional status in 32 patients (18 women and 14 men) and 32 matched healthy control subjects: 1) body composition, 2) dietary intake, 3) biochemical indexes of nutrition, and 4) and muscle strength (as a functional index). Mean daily intakes of fiber and phosphorus were significantly lower in CD patients than in control subjects. Serum concentrations of several nutrients (beta-carotene, vitamin C, vitamin E, selenium, and zinc) and activity of the enzyme glutathione peroxidase were also significantly lower in CD patients, as were antioxidant status and serum concentrations of magnesium and vitamin D. Percentage body fat and hamstring muscle strength were significantly lower in male CD patients than in control subjects, whereas muscle strength of the quadriceps was preserved. In conclusion, this study showed a variety of nutritional and functional deficiencies in patients with long-standing CD in remission, especially in male patients with a high lifetime prednisone dose. A comprehensive nutritional assessment seems superior to the assessment of a single dimension of nutritional status. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9583850/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/67.5.919 DB - PRIME DP - Unbound Medicine ER -