Tags

Type your tag names separated by a space and hit enter

Translational pauses during the synthesis of proteins and mRNA structure.
Nucleic Acids Symp Ser 1997; (37):179-80NA

Abstract

Translational pauses are observed during a spider fibroin synthesis (1,2). The spider major ampullate (dragline) silk of the spider Nephila clavipes is composed of multiple proteins. The amino acid sequences of the partial cDNA clones for the two major dragline silk fibroin components (Spidroin 1 and 2) exhibit repetitive motifs (3,4). Our detailed inspection of the nucleotide sequences of the repetitive motifs revealed highly selective site-specific codon usage patterns within a motif, suggesting that the secondary structure of the spider fibroin mRNA is optimized by the nucleotide sequence of the fibroin gene. The results, combined with our preceding results on silk fibroin from Bombyx mori (5) suggest that translational pauses of spider silk are interpreted in terms of the mRNA secondary structure.

Authors+Show Affiliations

National Institute of Radiological Sciences, Chiba-shi, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9586058

Citation

Zama, M. "Translational Pauses During the Synthesis of Proteins and mRNA Structure." Nucleic Acids Symposium Series, 1997, pp. 179-80.
Zama M. Translational pauses during the synthesis of proteins and mRNA structure. Nucleic Acids Symp Ser. 1997.
Zama, M. (1997). Translational pauses during the synthesis of proteins and mRNA structure. Nucleic Acids Symposium Series, (37), pp. 179-80.
Zama M. Translational Pauses During the Synthesis of Proteins and mRNA Structure. Nucleic Acids Symp Ser. 1997;(37)179-80. PubMed PMID: 9586058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Translational pauses during the synthesis of proteins and mRNA structure. A1 - Zama,M, PY - 1997/1/1/pubmed PY - 1998/5/20/medline PY - 1997/1/1/entrez SP - 179 EP - 80 JF - Nucleic acids symposium series JO - Nucleic Acids Symp. Ser. IS - 37 N2 - Translational pauses are observed during a spider fibroin synthesis (1,2). The spider major ampullate (dragline) silk of the spider Nephila clavipes is composed of multiple proteins. The amino acid sequences of the partial cDNA clones for the two major dragline silk fibroin components (Spidroin 1 and 2) exhibit repetitive motifs (3,4). Our detailed inspection of the nucleotide sequences of the repetitive motifs revealed highly selective site-specific codon usage patterns within a motif, suggesting that the secondary structure of the spider fibroin mRNA is optimized by the nucleotide sequence of the fibroin gene. The results, combined with our preceding results on silk fibroin from Bombyx mori (5) suggest that translational pauses of spider silk are interpreted in terms of the mRNA secondary structure. SN - 0261-3166 UR - https://www.unboundmedicine.com/medline/citation/9586058/Translational_pauses_during_the_synthesis_of_proteins_and_mRNA_structure_ DB - PRIME DP - Unbound Medicine ER -